6533b837fe1ef96bd12a205e
RESEARCH PRODUCT
Polyethylenimine is a strong inhibitor of human papillomavirus and cytomegalovirus infection.
Katrin BesoldLuise FlorinNils HanikSteffi KrauterAndreas F. M. KilbingerGilles A. SpodenBodo PlachterCarsten Lambertsubject
Human cytomegalovirusKeratinocytesGenetic enhancementCongenital cytomegalovirus infectionCytomegalovirusVirus AttachmentBiologyAntiviral Agentschemistry.chemical_compoundCationsChlorocebus aethiopsmedicineCytotoxic T cellAnimalsHumansPolyethyleneiminePharmacology (medical)Human papillomavirusPapillomaviridaePharmacologyPolyethyleniminePapillomavirus InfectionsFibroblastsAntimicrobialmedicine.diseaseVirologyMicrobicides for sexually transmitted diseasesInfectious DiseasesHEK293 CellschemistryMicroscopy FluorescenceOrgan SpecificityCOS CellsCytomegalovirus InfectionsHeLa Cellsdescription
ABSTRACT Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells with polyethylenimine blocked primary attachment of both viruses to cells, resulting in a significant reduction of infection. In addition, the dissemination of human cytomegalovirus in culture cells was efficiently reduced by recurrent administration of polyethylenimine. Polyethylenimine concentrations required for inhibition of human papillomavirus and cytomegalovirus did not cause any cytotoxic effects. Polyethylenimines and their derivatives may thus be attractive molecules for the development of antiviral microbicides.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-04-27 | Antimicrobial agents and chemotherapy |