Search results for " author"

Efficacy and safety of yttrium 90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for auto…

2007

A prospective, multicenter, nonrandomized phase 2 trial was conducted to evaluate the efficacy and safety of a single dose of yttrium-90 (90Y) ibritumomab tiuxetan in elderly patients in first relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL) ineligible for stem-cell transplantation. Patients had been previously treated with chemotherapy (group A, n = 76) or chemotherapy plus rituximab (group B, n = 28). Patients in group A were further divided into patients in whom induction therapy had failed (stratum AI, n = 33) and patients who had relapsed after achieving complete response (CR; stratum AII, n = 43). The overall response rate (ORR) was 52% and 53% in strata AI and AII…

The effect of observation timescales on the characterisation of extreme Mediterranean precipitation

2018

Abstract. This paper analyses the behaviour of five rainfall indicators (maximum intensity, cumulative rainfall, irregularity, probability of rain and persistence of rain) over different observation timescales ranging from 5 min to 24 h. It covers a large area on the Mediterranean side of the Iberian Peninsula (River Júcar Water Authority, 43 000 km2) on a continuous basis over a period of 14 years (1994–2007). The results show that the behaviour of extreme Mediterranean rainfall is heavily dependent on the observation timescale. There are a number of turning points in the indicator trends which occur on different timescales (1 and 6 h in the case of rain intensity and irregularity, 6 h for…

Preface

2018

This book represents the third noteworthy product of the Memità Network. The essays within this book constitute a critical approach from a linguistic and cultural point of view regarding authoritarianism’s reception in the media. In particular, the work opens up with a session whose purpose is to demonstrate the role of colonial press as an instrument of identity construction.

Pharmacy and pharmacology of biosimilars

2008

Biosimilar medicines are biological medicinal products that can obtain a marketing authorization in the EU after the original product (biological reference medicine) has run out of patent. As a prerequisite, studies including clinical trials are to be conducted to compare the quality, safety, and efficacy of the biosimilar and reference medicine. Due to the specific characteristics of biopharmaceuticals like complex 3-dimensional (glyco) protein structure, immunogenicity, production in living organisms, which causes heterogeneity, complex manufacturing process and analysis, interchangeability of the biosimilar with its reference drug product is not guaranteed. In addition, INN (internationa…

The pre-zygote identity as a moral issue.

2008

Introduction by the Editors

2015

Kohlberg’s approach to moral development and moral education continues to stimulate researchers and educators worldwide. His work still offers knowledge, methods and inspirations for understanding moral cognition and behavior, and how to foster it. This volume examines aspects of Kohlberg’s moral stage developmental theory and his theory of moral education to revisit their strengths and weaknesses in light of new questions and methods.

The role of the hospital pharmacy in the storage and supply of antidotes

2013

Cases of poisoning have been analyzed with the aim of estimating both the incidence and the seriousness of such xenobiotic effects, the major determinant agents, and the related antidotes used in hospital departments. From 2009 to November 2012, a survey of the availability of antidotes in the emergency room services was carried out in all hospital pharmacies under the Palermo Health Authority: Policlinico Paolo Giaccone, ARNAS Civico di Cristina Benefratelli, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello. Figures show that the majority of poisoning events were caused by the use/abuse of drugs, especially psychopharmaceuticals, alcohol and narcotic substances. This overdose of m…

The Concept of Authority

1995

There is a general agreement that the concept of practical authority can be analysed as a right to impose obligations or commands on its subject and that this right is correlated with a duty to obey. Usually it is also implied that these rights and duties are mutually recognized. Thus authority is considered as a consensus-based notion. But it is important to notice that political authorities can have other functions, too. They can change the normative positions of their subjects by permitting, authorizing, delegating, exercising a veto, by declaring acts valid or invalid, etc. They can create and change definition rules, e.g. determine the values of units of payment. They are often authori…

Direct synthesis of pure brannerite UTi2O6

2019

International audience; A new method based on the precipitation of uranium(IV) and titanium(IV) hydroxide precursors was developed to prepare pure brannerite UTi2O6 samples. In fact, U(IV) dissolved in HCl (6 mol L−1) was mixed to Ti (IV) alkoxyde before a basification step with an excess of NH4OH to obtain a highly reactive nanometric (U,Ti)(OH)4 powder. The obtained powder was then dried under vacuum, pressed into pellets and finally fired at 1300 °C. This method led to the formation of pure brannerite in contrast to previous reported protocols, which showed the formation of impurities such us UO2 and TiO2. The refined unit cell parameters of UTi2O6 led to a = 9.8113(2) Å, b = 3.7681(1) Å…

Regulatory evaluation of Glybera in Europe — two committees, one mission

2013

Representing the first gene therapy to be approved in the Western world, alipogene tiparvovec (Glybera; Uniqure) has recently been said to have had a “substantial impact from a regulatory perspective” (Nature Rev. Drug Discov. 11, 664; 2012) 1 . The therapy was granted marketing authorization in the European Union for the treatment of lipoprotein lipase deficiency, which results in a clinically heterogeneous condition with a risk of potentially life-threatening pancreatitis 2 , at the end of 2012. The decision followed a positive opinion by the European Medicines Agency (EMA)’s Committee for Medicinal Products for Human Use (CHMP) 3