Search results for " autoimmunity"
showing 8 items of 48 documents
Autophagy
2012
Klionsky, Daniel J. et al.
Does autoimmunity play a part in the pathogenesis of glaucoma?
2013
Glaucoma is a chronic neurodegenerative disease and one of the leading causes of blindness. Several risk factors have been described, e.g. an elevated intraocular pressure (IOP), oxidative stress or mitochondrial dysfunction. Additionally, alterations in serum antibody profiles of glaucoma patients, upregulation (e.g. anti-HSP60, anti-MBP) and downregulation (e.g. anti-14-3-3), have been described, but it still remains elusive if the autoantibodies seen in glaucoma are an epiphenomenon or causative. However, it is known that elicited autoimmunity causes retinal ganglion cell loss resulting in glaucomatous-like damage and according to the autoaggressive nature of some autoantibodies we found…
Regeneration After CNS Lesion: Help from the Immune System?
2010
Traumatic injury to the central nervous system (CNS) is followed by an inflammatory response, which is characterized by at least two very distinct phases: First, a short highly controlled burst of acute inflammatory defense and second, a long-term remodeling phase. Similarly, at least one or two phases of T-cell infiltration have been described in CNS trauma models suggesting differential functions of T cells in the acute and remodeling phase. Thus, the role of T cells in CNS trauma is still controversial. Interestingly, vaccine strategies and injections of autoimmune T cells led to both exacerbation of CNS damage after trauma in some models and improvement in others. Here, we suggest that …
Response to 'TH1 and TH2 cytokine control of thyrocyte survival in thyroid autoimmunity'
2001
Mirakian et al. question our recent results, which suggest that thyrocyte survival during thyroid autoimmunity depends on differential effects of TH1 and TH2 cytokines1. Thyrocyte destruction in autoimmune thyroiditis is a slow process that lasts several years. We hypothesized that in thyroid autoimmunity the balance between life and death in thyrocytes depends on the predominance over the time of TH2 and TH1 cytokines, whose action is not restricted to immune cells but involves direct modulation of key molecules responsible for survival or death of target cells1.
Neuro-endocrine networks controlling immune system in health and disease
2014
The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as multiple sclerosis (MS), might involve factors, hormones, and neural mediators that link the immune and nervous system. These molecules are members of the same superfamily, which allow the mutual and bi-directional neural–immune interaction. More recently, the discovery of leptin, one of the most abundant adipocyte-derived hormones that control food intake and metabolism, has suggested that nutritional/metabolic status, acting …
Transient chylomicronemia preceding the onset of insulin-dependent diabetes in a young girl with no humoral markers of islet autoimmunity
2004
OBJECTIVE: We investigated the possible causes of diabetes in a young child who presented with hyperglycemia associated with severe hypertriglyceridemia (>166 mmol/l), hypercholesterolemia (>38 mmol/l) and fasting chilomicrons. RESULTS: The patient did not have any of the HLA and autoantibody markers typically associated with type 1 diabetes. A glucose clamp failed to demonstrate insulin resistance (peripheral glucose utilization rate (M)=4.3 mg/kg per min) and there was no family history of type 2 diabetes or maturity onset diabetes in youth. Both fasting and stimulated C-peptide levels, including those in response to i.v. glucagon, were below the limit of detection. This is consiste…
Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease
2011
14 páginas, 8 figuras, 1 tabla.-- et al.
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.
2008
Contains fulltext : 70589.pdf (Publisher’s version ) (Closed access) OBJECTIVE: CO-releasing molecules (CO-RMs) are a novel class of anti-inflammatory agents. We have examined the possible therapeutic effects of CORM-3 in collagen-induced arthritis (CIA). METHODS: Arthritis was induced in DBA-1/J mice by type II collagen. Animals were treated with CORM-3 (5 and 10 mg/kg/day, intraperitoneally) or the inactive compound iCORM-3 (10 mg/kg/day, intraperitoneally) unable to release CO, from days 22 to 31. Production of anti-type II collagen antibodies, cytokines and cartilage olimeric matrix protein (COMP) was evaluated by enzyme-linked immunosorbent assay, and prostaglandin E(2) (PGE(2)) by rad…