Search results for " based"
showing 10 items of 848 documents
Liquid chromatography–mass spectrometry as a tool for wastewater-based epidemiology: Assessing new psychoactive substances and other human biomarkers
2017
Wastewater-based epidemiology (WBE) started to develop significantly in the last 8 years due, in part, to the advance of liquid chromatography–mass spectrometry (LC–MS). Its initial objective ― to estimate the consumption of illicit drugs ― has been expanded to new psychoactive substances (NPS) and other human biomarkers of health, lifestyle and disease. The purpose of this review is to introduce recent methods and outstanding challenges in the application of LC–MS to these new targets, including target, suspect and non-target screening and, outline the workflows developed for discovering metabolites of NPS and biomarkers. Further, we discuss a number of specific methodological challenges t…
“Team Based Learning” in Political Science studies
2019
En los estudios de Ciencia Política ha predominado tradicionalmente la metodología basada en la clase magistral y el trabajo individual. Sin embargo, la implantación del sistema de Bolonia implica un trabajo más autónomo de los estudiantes y el desarrollo de nuevas habilidades como el trabajo en grupo. Desde esta perspectiva, se ha aplicado una nueva metodología denominada Aprendizaje Basado en Grupos (TBL de sus siglas en inglés) a un grupo de 100 alumnos de Ciencia Política y se la ha comparado con otros tres métodos también utilizados por los mismos estudiantes en otras asignaturas del grado (práctica semanal, trabajo semestral y Aprendizaje Basado en Problemas). El objetivo del trabajo …
Recursive partitioning: an approach based on the weighted kemeny distance
2015
In the framework of preference rankings, the interest can lie in finding which predictors and which interactions are able to explain the observed preference structures. The possibility to derive consensus measures using a classification tree represents a novelty and an important tool, given its easy interpretability. This work proposes the use of a univariate decision tree for ranking data based on the weighted Kemeny distance. The performance of the methodology will be shown by using a real dataset about university rankings.
Manufacturing, characterization and control of cell-based medicinal products: challenging paradigms toward commercial use
2015
During the past decade, a large number of cell-based medicinal products have been tested in clinical trials for the treatment of various diseases and tissue defects. However, licensed products and those approaching marketing authorization are still few. One major area of challenge is the manufacturing and quality development of these complex products, for which significant manipulation of cells might be required. While the paradigms of quality, safety and efficacy must apply also to these innovative products, their demonstration may be demanding. Demonstration of comparability between production processes and batches may be difficult for cell-based medicinal products. Thus, the development …
Factors influencing inclusion in digestive cancer clinical trials: A population-based study
2015
Inclusion in a randomized therapeutic trial represents an optimal therapeutic strategy.To determine the influence of demographic characteristics and deprivation on the enrolment of patients in digestive cancer clinical trials.Between 2004 and 2010, 4632 patients were recorded by the Burgundy Digestive Cancer Registry. According to a balancing score, the 136 patients included in a clinical trial were matched with 272 patients who met the eligibility criteria for trials. Deprivation was measured by the ecological European deprivation index. A conditional multivariate logistic regression was performed.Patients aged over 75 years were significantly less likely to be included in clinical trials …
La Valutazione delle Tecnologie Sanitarie. The Health Technology Assessment
2004
The aim of this paper was to describe exhaustively, but concisely, the matter of the health technology assessment. It is a method of evaluating health technologies based on principles and tools of Evidence Based Medicine. We started from etymology to speak about its definition and implementation methodology. Moreover we guide the reader throughout the constellation of international societies of health technology assessment and the meaning of their international cooperation. Finally, we deal with the health technology assessment as a tool being an integral part of the clinical governance process.
A new shoreline change assessment approach for erosion management strategies
2022
Shoreline evolution studies are fundamental to assess the rate of beach accretion or retreatment. In the last years, researchers developed many methods with several techniques belonging to different disciplines and backgrounds. Nowadays, the Shoreline Change Analysis (SCA) is the most widespread method to assess shoreline evolution. In fact, the SCA is needed to perform management strategies able to respond to current erosion or potential future erosion problems. This paper presents a new approach using an automatic method for SCA with accuracy and speed improvements. Indeed, in the framework of the management of coastal erosion and to develop an adaptation plan to coastal hazards it is nec…
Knowledge representation for robotic vision based on conceptual spaces and attentive mechanisms
1995
A new cognitive architecture for artificial vision is proposed. The architecture is aimed for an autonomous intelligent system, as several cognitive hypotheses have been postulated as guidelines for its design. The design is based on a conceptual representation level between the subsymbolic level processing the sensory data, and the linguistic level describing scenes by means of a high-level language. The architecture is also based on the active role of a focus of attention mechanism in the link between the conceptual and the linguistic level. The link between the conceptual level and the linguistic level is modelled as a time-delay attractor neural network.
New Technology, Writing And Learning
2001
The participants involved in most previous studies on writing have written their texts by hand but writing with the aid of a computer is much more prevalent today. This chapter specifically examines the effects of new technology on writing and, by implication, on writing to learn, and presents examples how technology has created new possibilities for using writing for purposes of learning. The chapter is divided into four main parts. Part one briefly introduces the chapter. Part two considers the nature of writing in terms of interactions between planning, writing and editing. Part three examines how computer aided writing changes these processes. Here individual and collaborative writing a…
La comunità come rete di relazioni reciproche: percorsi collaborativi nella formazione iniziale degli insegnanti di sostegno
2017
Communities of practice can become a perfect place where teachers can reflect on their practice, share approaches, experiment with new content and new practices. The interaction between teachers in a community of practice encourages peer learning and stimulates problem solving. The present work, centered on the reciprocal teaching and project based learning methodologies, involved 195 disability and inclusion pre-service teachers and gave them the opportunity to experience the integration of the two teaching / learning models through which they learned how to collaborate and achieve results in effective way and working with others.