Search results for " beta"
showing 10 items of 1438 documents
Quenching of gA deduced from the β-spectrum shape of 113Cd measured with the COBRA experiment
2020
A dedicated study of the quenching of the weak axial-vector coupling strength gA in nuclear processes has been performed by the COBRA collaboration. This investigation is driven by nuclear model calculations which show that the β-spectrum shape of the fourfold forbidden non-unique decay of 113Cd strongly depends on the effective value of gA. Using an array of CdZnTe semiconductor detectors, 45 independent 113Cd spectra were obtained and interpreted in the context of three nuclear models. The resulting effective mean values are g‾A(ISM)=0.915±0.007, g‾A(MQPM)=0.911±0.013 and g‾A(IBFM-2)=0.955±0.022. These values agree well within the determined uncertainties and deviate significantly from th…
Are there positive lessons for Italy's NHS resulting from the Covid-19 pandemic?
2020
The authors evaluate the importance of prevention measures and health care from their own experience and briefly analyse the factors that may have contributed to the rapid spread of Covid-19 in Italy, and hope this will feed into appropriate and new and improved health policies.
Kawasaki disease epidemic: pitfalls
2020
AbstractRecent reports have described in the pediatric population a new type of hyperinflammatory response manifested following contact with SARS-CoV-2, with some of the clinical features attributable to Kawasaki disease (KD). The purpose of this commentary is to remark on a possible recent association between SARS-CoV-2 and KD. Although today little is known about the etiology of KD, the most accepted hypothesis is that of a probable viral etiology, therefore, even the SARS-CoV-2 virus could trigger, in genetically predisposed subjects, an exaggerated inflammatory response that is clinically evident like the one described in KD.
Spectroscopic studies of neutron-deficient light nuclei: decay properties of 21Mg, 25Si and 26P
2003
Neutron‐deficient nuclei with Tz equals to −3/2 and −2 have been produced at the GANIL/LISE3 facility in fragmentation reactions of a 95 MeV/u 36Ar primary beam in a 12C target. For the first time, β‐delayed proton and β‐γ emission has been simultaneously observed in the decay of 21Mg, 25Si and 26P. The decay scheme of the latter is proposed and the Gamow‐Teller strength distribution in its β decay is compared to shell‐model calculations based on the USD interaction. The B(GT) values derived from the absolute measurement of the β‐branching ratios are in agreement with the quenching factor of about 60% obtained for allowed Gamow‐Teller transitions in this mass region. A precise half‐life of …
Salmeterol Xinafoate (SX) loaded into mucoadhesive solid lipid microparticles for COPD treatment
2019
Chronic obstructive pulmonary disease (COPD) is one of the main health problems worldwide. It is characterised by chronic inflammation in the lungs that leads to progressive, chronic, largely irreversible airflow obstruction. The use of long-acting β agonists remain today the frontline treatment for COPD with the aim of minimizing side effects and enhancing therapeutic usefulness. To this purpose, in this paper, mucoadhesive solid lipid microparticles (SLMs) containing a long-acting β-2 agonist, Salmeterol Xinafoate (SX) were prepared, characterised (size, z-potential, aerodynamic diameter, turbidimetric evaluations, drug loading and entrapping efficiency) and tested in a model of bronchial…
Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells
2017
Spray-dried microparticles of a derivative of hyaluronic acid (HA) have been engineered to obtain a controlled aggregation with Human Mesenchymal Stem Cells (hMSCs) into 3D constructs. We demonstrated the utility of chemical functionalization of a native constituent of the extracellular matrix to improve processing performances and to control on stem cell adhesion and differentiation. Native hyaluronic acid (HA), cell adhesive peptides (RGD), transforming growth factor β3, dexamethasone are biological agents potentially suitable for chondrogenic stimulation of hMSCS. However unmodified HA suffers of drawbacks in terms of stability and versatility of processing. Functionalization strategies…
Isovector and isoscalar spin-multipole giant resonances in the parent and daughter nuclei of double-β-decay triplets
2022
The strength distributions, including giant resonances, of isovector and isoscalar spin-multipole transitions in the commonly studied double-β-decay triplets are computed in the framework of the quasiparticle random-phase approximation (QRPA) using the Bonn-A two-body interaction in no-core single-particle valence spaces. The studied nuclei include the double-β parent and daughter pairs (76Ge, 76Se), (82Se, 82Kr), (96Zr, 96Mo), (100Mo, 100Ru), (116Cd, 116Sn), (128Te, 128Xe), (130Te, 130Xe), and (136Xe, 136Ba). The studied transitions proceed from the ground states to the Jπ=0−,1−,2− (spin-dipole transitions) and Jπ=1+,2+,3+ (spin-quadrupole transitions) excited states in these nuclei. Compa…
Development of low-diffusion techniques for a high pressure xenon electroluminescent TPC
2022
El neutrino es una partícula que ha despertado un gran interés en las últimas décadas. Su existencia fue conjeturada por W. Pauli en 1930 para explicar el espectro continuo de la desintegración beta. El descubrimiento inequívoco de la oscilación de neutrinos en 1998 demostró que los neutrinos tienen una masa que no desaparece. Por lo tanto, es necesario acomodar un neutrino masivo en la teoría expandiendo el Modelo Estándar y eso se puede hacer suponiendo que el neutrino es una partícula de Majorana, que se define como un fermión que es su propia antipartícula. El mecanismo que da su masa a un neutrino Majorana podría explicar la leptogénesis y parte de la asimetría materia-antimateria obse…
SiPM based tracking for detector calibration in NEXT
2015
197 páginas. Tesis Doctoral del Departamento de Física Atómica, Molecular y Nuclear de la Universidad de Valencia y del Instituto de Física Corpuscular (IFIC).
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by su…
2010
Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate the activity of alpha-secretase, the major preventive secretase of Alzheimer's disease. Statins can increase the alpha-secretase activity by their cholesterol-lowering properties as well as by impairment of isoprenoids synthesis. In the present study, we elucidate the contribution of these pathways in alpha-secretase activation. We demonstrate that zaragozic acid, a potent inhibitor of squalene synthase which blocks cholesterol synthesis but allows synthesis of isoprenoids, also stimulates alpha-secretase activity. Treatment of human n…