Search results for " bone"

showing 10 items of 933 documents

Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies.

2011

The morphogen sonic hedgehog (Shh) seems to mediate adult repair processes in bone regeneration and vascularisation. In this study we investigated the effects of Shh on co-cultures consisting of human primary osteoblasts and outgrowth endothelial cells in terms of angiogenic activation and vessel maturation in comparison to the treatment with the commonly used proangiogenic factor, VEGF. Both, stimulation with VEGF or Shh, leads to an increase in the formation of microvessel-like structures compared to untreated controls. In contrast to VEGF, proangiogenic effects by Shh could already be observed after 24 h of treatment. Nevertheless, after 14 days the angiogenic activity of OEC was compara…

Vascular Endothelial Growth Factor Alcsh:Diseases of the musculoskeletal systemBone Regenerationmedicine.medical_treatmentFluorescent Antibody TechniqueAngiogenesis InhibitorsPolymerase Chain ReactionneovascularisationBasement MembraneDesminchemistry.chemical_compoundTransforming Growth Factor betaReceptors Platelet-Derived Growth FactorSonic hedgehogbiologyCell biologyUp-Regulationembryonic structuresElectrophoresis Polyacrylamide GelMorphogenmedicine.medical_specialtyanimal structuressignalling moleculesCyclopamineBlotting Westernlcsh:SurgeryNeovascularization PhysiologicEnzyme-Linked Immunosorbent AssayBone and BonesDownregulation and upregulationInternal medicinemedicineAngiopoietin-1HumansHedgehog ProteinsBone regenerationOsteoblastsGrowth factorEndothelial Cellslcsh:RD1-811bone repairco-cultureActinsCoculture TechniquesEndocrinologychemistryMyocardinbiology.proteinDesminlcsh:RC925-935AngiopoietinsEuropean cellsmaterials
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Augmented Reality of the Middle Ear Combining Otoendoscopy and Temporal Bone Computed Tomography

2018

International audience; HYPOTHESIS:Augmented reality (AR) may enhance otologic procedures by providing sub-millimetric accuracy and allowing the unification of information in a single screen.BACKGROUND:Several issues related to otologic procedures can be addressed through an AR system by providing sub-millimetric precision, supplying a global view of the middle ear cleft, and advantageously unifying the information in a single screen. The AR system is obtained by combining otoendoscopy with temporal bone computer tomography (CT).METHODS:Four human temporal bone specimens were explored by high-resolution CT-scan and dynamic otoendoscopy with video recordings. The initialization of the system…

Video RecordingOptical flowEar MiddleScale-invariant feature transformInitialization03 medical and health sciencesImaging Three-Dimensional0302 clinical medicine[INFO.INFO-IM]Computer Science [cs]/Medical ImagingHumansMedicineComputer vision[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs030223 otorhinolaryngologybusiness.industryTemporal BoneEndoscopyFrame rateSensory SystemsRefresh rateOtorhinolaryngologyFeature (computer vision)030220 oncology & carcinogenesisAugmented realityNeurology (clinical)Artificial intelligenceTomographyTomography X-Ray ComputedbusinessOtology & Neurotology
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Clinical effect of vitamin C supplementation on bone healing: A systematic review

2022

Background: The aim of the present systematic review was to evaluate the clinical effect of vitamin C on bone healing after bone fracture or bone reconstruction procedures. Material and Methods: In October 2020, Cochrane Library, Scopus and PubMed-Medline databases were searched without restrictions to identify animal and human studies that fulfilled the eligibility criteria. Outcome measures were bone healing time, bone gain (mm), bone density and adverse events. The risk of bias assessment of the selected studies was evaluated by means of Cochrane Collaboration's Tool for randomized clinical trials, while randomized clinical animal trials were assessed according to SYRCLE's tool. Addition…

Vitamina CBonescamSuplements nutritiusAscorbic AcidVitaminsDietary supplementsmucormycosisBone and BonesgingivaClinical trialsOtorhinolaryngologycovid-19giant cellsBone DensityDietary SupplementsOssosAnimalsHumansSurgeryVitamin CGeneral DentistryUNESCO:CIENCIAS MÉDICASAssaigs clínics
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How was the Turin Shroud Man crucified?

2014

As the literature is not exhaustive with reference to the way the Turin Shroud (TS) Man was crucified, and it is not easy to draw significant information from only a "photograph" of a man on a linen sheet, this study tries to add some detail on this issue based on both image processing of high resolution photos of the TS and on experimental tests on arms and legs of human cadavers. With regard to the TS Man hands, a first hypothesis states that the left hand of the TS Man was nailed twice at two different anatomical sites: the midcarpal joint medially to the pisiform between the lunate/pyramidal and capitate/uncinate bones (Destot's space) and the radiocarpal joint between the radio, lunate…

Wrist JointFamous PersonsMyocardial InfarctionPoison controlSettore MED/33 - Malattie Apparato LocomotoreShock TraumaticOrthopedics and Sports MedicineUlnar nerveForensic PathologyHistory AncientGeneral Environmental Scienceintegumentary systemMedicine (all)ContusionBiomechanical Phenomenamedicine.anatomical_structureMidcarpal jointNail (anatomy)Emergency MedicineTurin Shroud ManHomicideHumanmedicine.medical_specialtyCausalgiaContusionsTortureCause of deathViolenceChristianityAsphyxiaImmobilizationmedicineCadaverHumansCrucifixion techniquebusiness.industryFootWounds and InjurieFamous PersonMetacarpophalangeal jointHandSurgerybody regionsLunateTarsal BoneWounds and InjuriesGeneral Earth and Planetary SciencesForensic AnthropologyAnkleNailingbusiness
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Activin a and matrix metalloproteinase-2 and -9 blood levels as gauges of bone metastatic spread. In: Tumor microenvironment:Heterotypic interactions.

2006

activin a metallo proteinase-2 bone
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Impact of the coronavirus pandemic on maxillofacial trauma:a retrospective study in southern Spain

2022

The coronavirus pandemic has impacted health systems worldwide, with Spain being one of the most affected countries. However, little is known about the extent to which the effects of staying home, social distancing, and quarantine measures have influenced the epidemiology of patients with maxillofacial trauma. The aim of this study was to analyze the impact of the coronavirus pandemic on the incidence, demographic patterns, and characteristics of maxillofacial fractures in the largest hospital in southern Spain. Data from patients who underwent surgery for maxillofacial fractures during the first year of the pandemic between 16 March 2020 and 14 March 2021 (pandemic group) were retrospectiv…

adverse drug reactionsmicromedexoral pigmentationCoronavirusFractures BoneOtorhinolaryngologySpainHumansSurgeryMaxillofacial InjuriesGeneral DentistryPandemicsUNESCO:CIENCIAS MÉDICASRetrospective Studies
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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Influence of systemic strontium ranelate on the progression and as adjunctive therapy for the nonsurgical treatment of experimental periodontitis

2021

Made available in DSpace on 2022-05-01T11:39:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Universidade Estadual Paulista Background: Strontium Ranelate (SR) presents overlapping osteoanabolic and anti-resorptive activity. However, the effects of SR on the progression of periodontitis through the alveolar bone and its potential applicability as adjunctive therapy to scaling and root planning remain poorly accessed. The aim of this study was to evaluate the effects of systemic (SR) both on the progression of experimental periodontitis (EP) and as adjunctive therapy to SRP. Material and Methods: Eighty male rats were divided into four groups (n=20): EP-PSS: EP induction and …

alveolar bone lossstomatognathic diseasesroot planingStrontium RanelateResearchperiodontal diseasePeriodontologyenvironment and public healthGeneral DentistryUNESCO:CIENCIAS MÉDICAS
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Urban drinking and driving:comparison of electric scooter and bicycle related accidents in facial fracture patients

2022

In recent years, electric scooters (e-scooter) have emerged as an alternative mode of urban transport due to their availability and effortless use. However, e-scooter-related trauma and injuries, especially to the head, have received wide media coverage and raised public concern about their safety. We aim to determine and compare clinically relevant variables, incidence, and severity between bicycle and e-scooter-related facial fractures and potential protective measures for injury prevention. This retrospective study comprised all patients admitted to a tertiary trauma center with bicycle or e-scooter-related facial fractures between January 2019 and October 2020. Patient- and injury-relat…

and alveolar ridge augmentation. to assess the risk of biasand scopus. the search algorithms used the following key words: stem cellsbone rehabilitationOtorhinolaryngologybone regenerationstem cellstissue engineeringmedline completeSurgerythe study was developed following the criteria of the prisma guideline (2020). the literature review was conducted in pubmedGeneral Dentistryalveolar bone atrophyUNESCO:CIENCIAS MÉDICASthe caspe methodology was used
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Double-application of platelet-rich plasma on bone healing in rabbits

2010

Objective: Platelet-rich plasma (PRP) is considered to enhance bone formation especially at early stages of wound healing, depending on the limited and short life-span of platelets and growth factors. The aim of this study was to evaluate efficacy of double-application of PRP (DA-PRP) on bone healing in a rabbit calvarial defect model. Study design: Twenty-eight rabbits, each had two surgically prepared calvarial bone defects (10mm diameter), were included in this study and randomly divided into six groups. Defects (n=56) were treated with single-application of PRP (SA-PRP)(n=10), SA-PRP and beta-tricalciumphosphate (SA-PRP+TCP)(n=10), DA-PRP (n=8), DA-PRP and beta-tricalciumphosphate (DA-P…

animal diseasesDentistryBone healingBone and BonesAndrologyOsteogenesisStatistical analysesAnimalsBone formationPlateletGeneral DentistryWound HealingCalvarial defectPlatelet-Rich PlasmaChemistrybusiness.industrySignificant differenceClinical and Experimental dentistry:CIENCIAS MÉDICAS [UNESCO]nervous system diseasesOtorhinolaryngologyPlatelet-rich plasmaUNESCO::CIENCIAS MÉDICASFemaleResearch-ArticleSurgeryRabbitsbusinessWound healing
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