Search results for " box"
showing 10 items of 161 documents
Dialog Structure Automatic Modeling
2010
This paper presents the approach implemented as part of a conversational bot named WIH (Word Intelligent Handler). It has a complex architecture with several components. Some of them are the ER-memory, EP-memory and other minor modules that provide the prototype of good modeling of Spanish sentences. They constitute the knowledge-representation mechanism that is used by WIH to build automatic answers during dialogs with humans. In this paper a small description of these components and some of its interaction is given, along with test cases and a statistical analysis of the results obtained. It is shown here that WIH prototype can adapt its behavior and learning rate of its internal working …
Domain Expert Platform for Goal-Oriented Dialog Collection
2021
Today, most dialogue systems are fully or partly built using neural network architectures. A crucial prerequisite for the creation of a goal-oriented neural network dialogue system is a dataset that represents typical dialogue scenarios and includes various semantic annotations, e.g. intents, slots and dialogue actions, that are necessary for training a particular neural network architecture. In this demonstration paper, we present an easy to use interface and its back-end which is oriented to domain experts for the collection of goal-oriented dialogue samples. The platform not only allows to collect or write sample dialogues in a structured way, but also provides a means for simple annotat…
EFFECT OF LOW-FREQUENCY NOISE ON ADIABATIC PASSAGE IN A SUPERCONDUCTING NANOCIRCUIT
2011
Recent experiments have demonstrated coherent phenomena in three-level systems based on superconducting nanocircuits. This opens the possibility to detect Stimulated Raman Adiabatic Passage (STIRAP) in artificial atoms. Low-fequency noise (often 1/f) is one of the main sources of decoherence in these systems, and we study its effect on the transfer efficiency. We propose a way to analyze low frequency fluctuations in terms of fictitious correlated fluctuations of external parameters. We discuss a specific implementation, namely the Quantronium setup of a Cooper-pair box, showing that optimizing the trade-off between efficient coupling and protection against noise may allow us to observe co…
Definition and Performance Evaluation of a Robust SVM Based Fall Detection Solution
2012
We propose an automatic approach to detect falls in home environment. A Support Vector Machine based classifier is fed by a set of selected features extracted from human body silhouette tracking. The classifier is followed by filtering operations taking into account the temporal nature of a video. The features are based on height and width of human body bounding box, the user's trajectory with her/his orientation, Projection Histograms and moments of order 0, 1 and 2. We study several combinations of usual transformations of the features (Fourier Transform, Wavelet transform, first and second derivatives), and we show experimentally that it is possible to achieve high performance using a si…
Promoter and exon–intron structure of the protein kinase C gene from the marine sponge Geodia cydonium: evolutionary considerations and promoter acti…
1999
Abstract We report the gene structure of a key signaling molecule from a marine sponge, Geodia cydonium. The selected gene, which codes for a classical protein kinase C (cPKC), comprises 13 exons and 12 introns; the introns are, in contrast to those found in cPKC from higher Metazoa, small in size ranging from 93 nt to 359 nt. The complete gene has a length of 4229 nt and contains exons which encode the characteristic putative regulatory and catalytic domains of metazoan cPKCs. While in the regulatory domain only one intron is in phase 0, in the catalytic domain most introns are phase 0 introns, suggesting that the latter only rarely undergo module duplication. The 5′-flanking sequence of t…
Cloning and functional analyses of the mouse tapasin promoter
2003
The expression of tapasin is critical for an optimized MHC class I assembly and stable MHC class I surface expression. Thus, impaired MHC class I antigen expression of tumors can be attributable to tapasin downregulation. In order to understand the molecular mechanisms of deficient tapasin expression, the mouse tapasin promoter region and its 5'-flanking sequences were characterized. The mouse tapasin promoter lacks the TATA box and its transcription is initiated at multiple sites within a 51-nucleotide stretch. Sequence analyses revealed transcription factor binding motifs for NF-kappaB, GATA, E2F, p300, AP1, SP1 and IRF-1/2. Detailed analysis of deletion mutants and elimination of transcr…
The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity
2012
SummaryRIG-I is a cytosolic pathogen recognition receptor that initiates immune responses against RNA viruses. Upon viral RNA recognition, antiviral signaling requires RIG-I redistribution from the cytosol to membranes where it binds the adaptor protein, MAVS. Here we identify the mitochondrial targeting chaperone protein, 14-3-3ε, as a RIG-I-binding partner and essential component of a translocation complex or “translocon” containing RIG-I, 14-3-3ε, and the TRIM25 ubiquitin ligase. The RIG-I translocon directs RIG-I redistribution from the cytosol to membranes where it mediates MAVS-dependent innate immune signaling during acute RNA virus infection. 14-3-3ε is essential for the stable inte…
An improved quantum query algorithm for computing AND Boolean function
2010
We consider the quantum query model for computing Boolean functions. The definition of the function is known, but a black box contains the input X = (x 1 , x 2 , …, x n ). Black box can be accessed by querying x i values. The goal is to develop an algorithm, which would compute the function value for arbitrary input using as few queries to the black box as possible. We present two different quantum query algorithms for computing the basic Boolean function — logical AND of two bits. Both algorithms use only one query to determine the function value. Correct answer probability for the first algorithm is 80%, but for the second algorithm it is 90%. To compute this function with the same probab…
Genome-wide analysis of factors regulating gene expression in liver
2007
In recent decades, multiple individual genes have been studied with respect to their level of expression in liver tissue and in many cases substantial progress has been made in identifying individual factors promoting gene expression in liver. However, the overall picture is still undefined and general rules or factors regulating gene expression in liver have not yet been established. Thus, a genome-wide screen for factors regulating gene expression in liver is of high interest, as it may reveal common regulatory mechanisms for most genes highly expressed in liver. These factors represent potential new targets in liver disease associated with differential gene expression. Using a novel bioi…
Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells
2012
Background: Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of the forkhead transcription factors' family, FoxO3a, has been implicated in the expression of the proapoptotic protein Bim (a Bcl-2-interacting mediator of cell death). In this study, we used human HepG2 liver cancer cells as an in vitro model to investigate whether melatonin treatment induces Bim through regulation by the transcription factor FoxO3a. Methods: Cytotoxicity of melatonin was compared in HepG2 hepatoblastoma cells and primary human hepatocytes. Proapoptotic Bim expression was analys…