Search results for " cD"
showing 10 items of 587 documents
Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease
2020
Abstract Background Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been uncovered, little is known about the genetic architecture of early AMD. Methods To identify genetic factors for early AMD, we conducted a genome-wide association study (GWAS) meta-analysis (14,034 cases, 91,214 controls, 11 sources of data including the International AMD Genomics Consortium, IAMDGC, and UK Biobank, UKBB). We ascertained early AMD via color fundus photographs by manual grading for 10 sources and via an automated machine learning approach for > 170,000 photographs from UKBB. We searched for early AMD loc…
The janus face of NKT cell function in autoimmunity and infectious diseases
2018
Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defence against infections but, on the other hand, their effector functions can be involved in the pathogenesis of sev…
Inactivation of the KSRP gene modifies collagen antibody induced arthritis.
2017
Abstract The KH type splicing regulatory protein (KSRP) is a nucleic acid binding protein, which negatively regulates the stability and/or translatability of many mRNA species encoding immune-relevant proteins. As KSRP is expressed in immune cells including T and B cells, neutrophils, macrophages and dendritic cells, we wanted to analyze its importance for the development of autoimmune diseases. We chose collagen antibody-induced arthritis (CAIA) as an appropriate autoimmune disease mouse model in which neutrophils and macrophages constitute the main effector cell populations. We compared arthritis induction in wild type (WT) and KSRP−/− mice and paws were taken for histological sections an…
Behavioral and clinical characteristics of people receiving medical care for HIV infection in an outpatient facility in Sicily, Italy
2016
Paola Di Carlo,1 Giuliana Guadagnino,1 Palmira Immordino,1 Giovanni Mazzola,2 Pietro Colletti,2 Ilenia Alongi,1 Lucia Adamoli,1 Francesco Vitale,1 Alessandra Casuccio1 1Department of Sciences for Health Promotion and Mother-Child Care “G D’Alessandro”, University of Palermo, 2Department of Medicinal Clinics and Emerging Diseases, “Paolo Giaccone” Polyclinic University Hospital, Palermo, Italy Aim: The authors examined a cohort of HIV-positive outpatients at the AIDS Center of Palermo University in Italy in order to identify factors related to the frequency of their visits to the outpatient facility for health care services.Methods: Two hundr…
Pirmā tipa cukura diabēts un tā sarežģījumi grūtniecības laikā
2018
Grūtniecība 1.tipa CD pacientēm var noritēt veiksmīgi, ja glikozes līmenis asinīs ir tuvu normas robežai gan plānojot grūtniecību, gan tās laikā. Tādēļ ir svarīgi izprast glikozes metabolisma izmaiņas grūtniecības laikā un to ietekmi uz augļa un mātes veselību, samazinot komplikāciju risku grūtniecības laikā. Pētījuma mērķis bija analizēt ar 1.tipa CD saistītos sarežģījumus grūtniecēm un viņu jaundzimušajiem. Pētījuma uzdevumi bija izpētīt CD apmācības un HbA1c līmeņa saistību ar grūtniecības iznākumu, kā arī izpētīt iespējamos ar metabolo kompensāciju saistītos sarežģījumus katrā grūtniecības trimestrī un pēcdzemdību periodā un noskaidrot grūtnieces svara ietekmi uz grūtniecības iznākumu. …
Measurement of the W boson mass
1996
The W boson mass is measured using proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 1.7fb(-1) recorded during 2016 by the LHCb experiment. With a simultaneous fit of the muon q/p(T) distribution of a sample of W ->mu y decays and the phi* distribution of a sample of Z -> mu mu decays the W boson mass is determined to be
2. tipa cukura diabēta pacientu individualizēta terapija un tās nozīmēšanas kritēriji atbilstoši fenotipam
2015
2.tipa cukura diabēts ir hroniska slimība,kuras izplatība strauji pieaug visā pasaulē.Neraugoties uz izstrādātām vadlīnijām ārstiem,kā sākt2.tipaCD ārstēšanu,ne visi pacienti sasniedz mērķa glikēmiju un glikēta hemoglobīna(HbA1c)līmeni.Izpētīti228akūti hospitalizēti 2.tipaCD pacienti,kuri ārstējās no2013.gada janvāra līdz2014.gada septembrim.Liela uzmanība pievērsta pacientu bioķīmiskajiem radītājiem:triglicerīdi(TG), c-peptīds,HbA1c,GFĀ,ĶMI,ārstam,kas ārstēja noteiktu pacientu,terapijas izvēlei,pacientam izrakstoties no stacionāra. Fenotipiski pacienti sadalīti četrās grupās.Pirmajā grupā bija73pacienti ar hronisku nieru slimību(GFĀ30 kg/m2),66cilvēki bija vecāka gadagājuma pacientu grupā(…
Inhibición de complejos cdk/ciclina en modelos celulares de patología
2012
La proliferación celular descontrolada es el resultado de diversos mecanismos que conducen a un proceso patológico. Uno de ellos, es el desarrollo de aberraciones en cualquier punto de la maquinaria molecular que gobierna el ciclo celular y otro es la desregulación del receptor del factor de crecimiento epidérmico (EGFR). Los tratamientos tumorales convencionales han mejorado sin duda durante las últimas décadas, pero sigue siendo necesaria la búsqueda de nuevas estrategias terapéuticas. Las nuevas terapias están dirigiéndose hacia la inhibición simultanea de rutas proximales, puede favorecer la efectividad de los tratamientos antitumorales. En este trabajo de tesis presentamos los estudios…
Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy
2019
The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and additionally, recent evidence shows that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary-open angle glaucoma patients (POAG) compared to healthy controls. Synthetically antibody-derived peptides can modulate various effector functions of the immune system and act as antimicrobial or antiviral molecules. In an ex vivo adolescent glaucoma model, this study, for the first time, demonstrates that polyclonal-derived complementarity-determining regions (CDRs) can significantly increase the survival rate …
Identification and expansion of human colon-cancer-initiating cells
2007
Colon carcinoma is the second most common cause of death from cancer. The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures. Although there is increasing evidence that a rare population of undifferentiated cells is responsible for tumour formation and maintenance, this has not been explored for colorectal cancer. Here, we show that tumorigenic cells in colon cancer are included in the high-density CD133+ population, which accounts for about 2.5% of the tumour cells. Subcutaneous injection of colon cancer CD133+ cells readily reproduced the original tumour in immunodeficient mice, whereas CD133- cells did not form …