Search results for " cardiac"

Cardiac magnetic resonance versus echocardiography for the assessment of cardiac volumes and function in thalassemia major patients

2012

Carga de hospitalizaciones recurrentes tras una hospitalización por insuficiencia cardiaca aguda: insuficiencia cardiaca con función sistólica conser…

2017

Introduction and objectives: Heart failure with preserved ejection fraction and reduced ejection fraction share a high mortality risk. However, differences in the rehospitalization burden over time between these 2 entities remains unclear. Methods: We prospectively included 2013 consecutive patients discharged for acute heart failure. Of these, 1082 (53.7%) had heart failure with preserved ejection fraction and 931 (46.2%) had heart failure with reduced ejection fraction. Cox and negative binomial regression methods were used to evaluate the risks of death and repeat hospitalizations, respectively. Results: At a median follow-up of 2.36 years (interquartile range: 0.96-4.65), 1018 patients …

Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation

2021

Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …

Cardioradiologia: miti e realtà di una nuova era dell’imaging

2011

Utilidad de la electroestimulación muscular funcional y el entrenamiento de la musculatura inspiratoria en pacientes con insuficiencia cardiaca con f…

2018

“UTILIDAD DE LA ELECTROESTIMULACIÓN MUSCULAR Y ENTRENAMIENTO DE LA MUSCULATURA INSPIRATORIA EN PACIENTES CON INSUFICIENCIA CARDIACA Y FUNCIÓN SISTÓLICA PRESERVADA” ENSAYO CLÍNICO TRAINING HF La insuficiencia cardiaca con función sistólica preservada (ICFSp) es un síndrome clínico bien definido que representa al menos el 50% del total de insuficiencias cardiacas, aunque se estima incluso un aumento de su prevalencia relacionada con el envejecimiento de la población. Desde el punto de vista epidemiológico estos pacientes presentan una mayor edad, existe un predominio femenino y asocian un importante número de comorbilidades como hipertensión arterial, diabetes mellitus y sobrepeso. La caracte…

Linee guida attuali e future del trattamento dello scompenso cardiaco

2006

QT Indexes in Cirrhotic Patients: Relationship with Clinical Variables and Potential Diagnostic Predictive Value.

2015

Background and Aims A wide spectrum of cardiovascular changes characterizes cirrhosis, ranging from subclinical alterations to hyperkinetic syndrome. We looked for ECG markers of ventricular repolarization in a population of patients with cirrhosis in comparison to patients without cirrhosis and we investigated the relationship between these and other clinical and laboratory variables. Methods In 149 patients with cirrhosis and 152 controls, we measured QT maximum interval (QTmax), QT corrected interval (QTc), QT minimum interval (QTmin), QT dispersion (QTdisp), QT peak and T peak-to-end (TpTe). Results In subjects with cirrhosis, in comparison with controls, we observed a higher mean QTmax…

Long term prognosis of patients with cardiac syndrome X: data from the Italian Registry of Syndrome X (RISX)

2009

Long term prognosis of patients with cardiac syndrome X: data from the Italian Registry of Syndrome X (RISX)

ST segment elevations: Always a marker of acute myocardial infarction?

2013

AbstractChest pain is one of the chief presenting complaints among patients attending Emergency department. The diagnosis of acute myocardial infarction may be a challenge. Various tools such as anamnesis, blood sample (with evaluation of markers of myocardial necrosis), ultrasound techniques and coronary computed tomography could be useful. However, the interpretation of electrocardiograms of these patients may be a real concern. The earliest manifestations of myocardial ischemia typically interest T waves and ST segment. Despite the high sensitivity, ST segment deviation has however poor specificity since it may be observed in many other cardiac and non-cardiac conditions. Therefore, when…

A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?

2018

Bicuspid valve disease is associated with the development of thoracic aortic aneurysm. The molecular mechanisms underlying this association still need to be clarified. Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm. We unveiled that the circulating levels of the MAIT, CD4+IL−17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm. Among patients with tricuspid aortic…