Search results for " causes"
showing 10 items of 35 documents
The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions
2013
The validated EndoPredict assay is a novel tool to predict the risk of metastases of patients with estrogen receptor positive, HER2 negative breast cancer treated with endocrine therapy alone. It has been designed to integrate genomic and clinical information and includes clinico-pathological factors such as tumor size and nodal status. The test is feasible in a decentral setting in molecular pathology laboratories. In this project, we investigated the performance of this test in clinical practice, and performed a retrospective evaluation of its impact on treatment decisions in breast cancer. During one year, EndoPredict assays from 167 patients could be successfully performed. For retrospe…
Evaluation of salivary parameters and dental status in adult hemodialysis patients in an indian population.
2018
Background Renal failure is a process that expresses a loss of functional capacity of the nephrons, independently of its etiology. The most widely used technique to combat renal failure is hemodialysis. Renal failure causes various systemic alterations including oral complications such as variations in the flow and composition of the saliva. Caries is a multifactorial disease and impaired stimulated salivary flow rate and buffering capacity are the best-known risk factors. The present study aims to evaluate the salivary pH, buffering capacity and the flow rate of saliva to the DMFT status in adult hemodialysis patients among the Indian population. Material and Methods Twenty healthy individ…
Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
2017
BACKGROUND: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. OBJECTIVES: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. METHODS: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-speci…
The role of heavy vehicles in road safety: Technical improvements and training of professional drivers in EU activities
2011
This paper proposes an analysis of initiatives and measures that the EU has developed, both in terms of research and normative, in order to improve the safety of freight vehicles. The actions undertaken by the EU under the program for road safety, with particular attention to the road freight sector, the more representative, are the following: - Improving the visibility of heavy duty vehicles (HDV), - The elimination of points with poor visibility from the HDV, - Evaluation of measures to reduce accidents related to tires condition, - The standardization and improvement of initial and continuing training of professional drivers. The classification of defects which are considered to have ser…
Rateless Codes Performance Analysis in Correlated Channel Model for GEO Free Space Optics Downlinks
2012
Genealogia della normatività. La normatività come controllo
2018
In this paper I draw the outline of a psychological genealogy of normativity: an account of normativity as a complex neuro-psychological fact, entirely analysable in non-normative terms. As a first step, I introduce two of the main problems faced by the genealogical approach. I call the first one “Gibbard problem”: what kind of neuro-psychological state is normative judgment? I call the second one “irreducibility of normativity problem”: normative dynamics seem to be irreducible to causal dynamics. As a second step, I examine the “dual model” of the psychology of normative judgment developed by J. Haidt and J. Greene. I argue that the dual model is not able to solve the aforementioned probl…
L'Analogie chez Aristote
2021
Revue de philosophie dont l’objet est de montrer, d’interroger ou d’évaluer les comparaisons effectives dans les différents champs disciplinaires, Analogia est une publication scientifique annuelle de l’IPC.Chaque numéro réunit un conseil scientifique nouveau chargé de sélectionner les contributions en double aveugle.L’Analogie chez Aristote.Sous la direction d’Emmanuel Brochier.Conseil scientifique :- Katerina Ierodiakonou (Genève – Athènes)- André Laks (Paris)- Benjamin C. Morison (Princeton)- Jean-Luc Solère (Boston)Sommaire :- Présentation, par Emmanuel Brochier, p. 5 ;- Christof Rapp : "Spotting similarities between disparate items" Observations on the use of analogy in Aristotle’s met…
Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes
2013
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of whole or large partial chromosome segments. A recent whole genome sequencing effort yielded no frequently recurring mutations in genes other than those affecting ALK. However, the study further stresses the importance of DNA copy number alterations in this disease, in particular for genes implicated in neuritogenesis. Here we provide additional evidence for the importance of focal DNA copy number gains and losses, which are predominantly observed in MYCN amplified tumors. A focal 5 kb…
La recente riforma della disciplina italiana del subappalto nella prospettiva del bid rigging
2023
L’articolo analizza in chiave critica la disciplina nazionale del subappalto nell’ambito delle gare pubbliche, così come recentemente riformata a seguito di diversi interventi normativi in ottemperanza alla procedura d’infrazione avviata dalla Commissione UE. Stando alla tesi dell’A., l’attuale quadro normativo – caratterizzato dalla quasi totale eliminazione delle limitazioni previgenti (probabilmente anche spingendosi oltre ciò che la Commissione UE ha richiesto) – difetta nel trovare un equo bilanciamento tra il principio della massima partecipazione alla gara, da un lato, e l’esigenza di prevenire e svelare potenziali condotte collusive, dall’altro. La suddetta conclusione, peraltro, ap…
Evaluación de la calidad de los diagnósticos premortem de causas de muerte en las autopsias del Hospital Clínico Universitario de Valencia (1985-1992)
2009
Se estudiaron 998 autopsias realizadas en el Servicio de Anatomía Patológica del Hospital Clínico Universitario de Valencia entre 1985 y 1992, introducidas y procesadas en el Sistema Automatizado de Registro y Control de Anatomía Patológica (SARCAP) en el Hospital «Hermanos Ameijeiras» de La Habana, Cuba. Los principales resultados fueron: predominio del sexo masculino y las edades avanzadas; las principales causas básicas de muerte fueron los tumores malignos, la ateromatosis coronaria, la cirrosis hepática y el SIDA, y las principales causas directas de muerte fueron la bronconeumonía, la extensión del cáncer y el tromboembolismo pulmonar. Hubo 10,6% de discrepancias diagnósticas premorte…