Search results for " chimica"
showing 10 items of 3438 documents
Profilo fitochimico di prodotti naturali e loro derivati emisintetici ad attività antitumorale e acaricida
2022
Nuovi inibitori di Aurora chinasi A come target biologico coinvolto nei processi carcinogenici
2011
Identificando Aurora chinasi A come target elettivo per l’inibizione dell’espansione tumorale è stato sfruttato l’approccio computazionale per effettuare un virtual screening su una libreria “in house” di strutture molecolari. L’analisi dei dati computazionali ha permesso di identificare nei derivati della serie pirido[3’,2’:4,5]furo[3,2-d]-1,2,3-triazin-4(3H)one di tipo 3 nuovi composti a potenziale attività inibitoria sul sito ATP-asico di Aurora chinasi A. La sintesi del sistema triciclico-eteroaromatico 3 prevede la diazotazione della 3-amino-furopiridina 1 e conseguente reazione di copulazione con una serie di ammine primarie opportunamente scelte, permettendo l’isolamento delle 3-tria…
Differenziazione e quantificazione dei carbonati litogenici e pedogenici di Gypsisuoli forestali attraverso l'analisi isotopica
2004
Gli autori riferiscono sui tipi e sui modelli di genesi dei carbonati dei suoli, attraverso l’uso degli isotopi del 13C. Lo studio è stato condotto in un’area dell’interno collinare argilloso siciliano, su suoli che evolvono sui depositi evaporitici della Serie Gessoso-Solfifera. Sono stati scelti cinque pedon su litotipi calcarei e non. I pedon sono stati descritti in campo e campionati secondo la sequenza degli orizzonti genetici; sui campioni di suolo sono state eseguite le seguenti analisi: tessitura, reazione, conducibilità elettrica, gesso, carbonio organico ed inorganico. Inoltre, parallelamente sono state eseguite le analisi isotopiche del carbonio organico ed inorganico. I risultat…
Template electrodeposition and characterization of nanostructured Pb as a negative electrode for lead-acid battery
2019
Abstract Despite Lead Acid Battery (LAB) is the oldest electrochemical energy storage system, diffusion in the emerging sectors of technological interest is inhibited by its drawbacks. The principal ones are low energy density and negative plate sulphating on high rate discharging. In this work, it is shown the possibility of overcoming such drawbacks by using nanostructured lead as a negative electrode. Lead nanowires (NWs) were fabricated by electrochemical deposition in template, which is an easy, cheap, and easily scalable process. Their morphology and crystal structure have been characterized by electron microscopy and X-ray diffraction, respectively. An electrochemical cell simulating…
Synthesis of aryl azides: A probe reaction to study the synergetic action of ultrasounds and ionic liquids
2011
Abstract The combined effect of ultrasounds and ionic liquids was used to perform the synthesis of aryl azides by nucleophilic aromatic substitution in ionic liquid/[1-butyl-3-methylimidazolium][N 3 ] binary mixtures. The ultrasounds efficiency was analyzed as a function of the substrate and of the ionic liquid structure. In the first case, both 6π and 10π electrons aryl halides were considered. As far as the ionic liquid structure is concerned, both aromatic and aliphatic ionic liquids were taken into account. Among aromatic cations, the effects due to different ability in giving hydrogen bond or π–π interactions were considered. The use of a geminal ionic liquid having an aromatic spacer …
Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy) pyrazole derivatives
2011
The antibacterial and antifungal activity of a series of products, in which the 1,5-dimethyl-4-(cyano- NNO-azoxy)pyrazol-3-yl and 1,3-dimethyl-4-(cyano-NNO-azoxy)pyrazol-5-yl moieties were linked to pyridine, pyrazole, isoxazole, thiophene and the furan ring, were examined. No molecule displayed activity against the Gram-negative bacteria tested. Conversely, some compounds displayed activity against two Staphylococcus aureus strains, including the methicillin resistant strain. All compounds displayed interesting antifungal activity, the most active compound of the series being the thiophene derivative 7a. This compound’s activity against Candida krusei and Candida glabrata (MIC = 0.25 and 0…
Mechanistic Investigations of the BZ Reaction with Oxalic Acid Substrate. I. The Oscillatory Parameter Region and Rate Constants Measured for the Rea…
2004
This paper is the first part of a study reinvestigating the mechanism of the Belousov-Zhabotinsky (BZ) reaction of oxalic acid, which is the simplest organic substrate for a BZ oscillator. New experiments are performed to find the oscillatory region in 1 M sulfuric acid at 20 °C. The removal rate of the end product bromine by an inert gas stream is a critical parameter here: oscillations can be observed only in a window of that parameter. The “rate constant” for the physical removal of bromine is measured as a function of the gas flow rate and reactor volume; furthermore, the rate constants of three component reactions important in this system are also determined. These are oxygen atom tran…