Search results for " chimica"
showing 10 items of 3438 documents
New Insight on Medieval Painting in Sicily: The Virgin Hodegetria Panel in Monreale Cathedral (Palermo, Italy)
2023
: The Virgin Hodegetria, located in the Cathedral of Santa Maria Nuova in Monreale, near Palermo (Italy), probably dating the first half of the 13th century, is one of the earliest examples of medieval panel painting in Sicily. A diagnostic campaign was carried out on the panel aiming to identify the constituting materials and the executive technique, as well as to assess the state of conservation for supporting the methodological choice of the restoration intervention. Both non invasive (X-ray radiography, digital microscope, multispectral imaging, ED-X-ray fluorescence) and micro-invasive (polarised light microscopy, ESEM-EDX, ATR-FTIR spectroscopy and micro-Raman spectroscopy) analyses w…
Cationic microemulsion hosting polynucleotides: Effect of NaCl on host and guest
2004
The structural features of the quaternary water-in-oil microemulsion CTAB/n-hexane/n-pentanol/water in the presence of fairly high concentrations of NaCl and of relatively high molecular weight polynucleotides have been determined. Even in these severe conditions, the hosting system can still be depicted as formed by water droplets stabilised by a surfactant/cosurfactant layer. Moreover, the time stability of the host/guest system has been evaluated and the phase behaviour of the hosting system in the presence of increasing concentrations of NaCl determined.
Understanding the Interactions of Guanine Quadruplexes with Peptides as Novel Strategies for Diagnosis or Tuning Biological Functions
2023
Guanine quadruplexes (G4s) are nucleic acid structures exhibiting a complex structural behavior and exerting crucial biological functions, in both cells and viruses. The specific interactions of peptides with G4s, as well as the understanding of the factors driving the specific recognition, are important for the rational design of both therapeutic and diagnostic agents. In the present minireview, we examine the most important studies dealing with the interactions between G4s and peptides, highlighting the strengths and limitations of the present analytic approaches. We also show how the combined use of high-level molecular simulation techniques and experimental spectroscopy represents the b…
Silk-Water: a dynamic duo
2010
Sintesi di un nuovo sensore fluorescente selettivo per Hg2++ contenente ossadiazoli fluorurati
2009
Heterogeneous photocatalysis: guidelines on experimental setup, catalyst characterization, interpretation, and assessment of reactivity
2019
Soon after the publication of the first pioneering works on heterogeneous photocatalysis, the number of papers on this topic continuously increased. This intriguing field of research is very complex as it endows with an interdisciplinary overview that involves different aspects of chemistry, physics, material and environmental sciences. Even if photocatalytic applications in real processes are often difficult to be implemented and scaled-up, investigations at laboratory scale are easy to be performed, and in some cases they may give rise to misconceptions. For this reason, the present work aims to sum up most of the common experimental techniques and procedures generally used in heterogeneo…
Il fitochimico indicaxantina previene stress ossidativo, arresto del ciclo cellulare ed apoptosi indotta da 7-Ketocolesterolo in monociti-macrofagi u…
2012
PHYTOCHEMICAL INDICAXANTHIN PREVENTS 7-ketoCHOLESTEROL-INDUCED OXIDATIVE STRESS, CELL CYCLE ARREST AND APOPTOSIS IN HUMAN MONOCYTES- MACROPHAGES.
Sviluppo di metodi analitico-tossicologici per la determinazione di PCDD/F e PCB in matrice ambientale. Livelli di contaminazione per la Regione Sici…
2012
Substituent effects on the mechanism changeover in a multipathway reaction: A model for the behavior of biological systems?
2009
By studying the rearrangement in dioxane/water of a series of (Z)-arylhydrazones of 5-amino-3- benzoyl-1,2,4-oxadiazole (1a-k) into the relevant (2-aryl-5-phenyl-2H-1,2,3-triazol-4-yl)ureas (2a-k) in a wide range of pS + (an operational scale of proton concentration in the mixed solvent used; dioxane/water, 1:1, v:v), the occurrence of three different reaction pathways (specific-acid- catalyzed, uncatalyzed, and general-base-catalyzed) for the relevant SNi process has been recently enlightened. The significantly different substituent effects on the three pathways cause some crossovers in the log kA,R versus pS + plots. Both the pS + value at which the crossover occurs and the width of the u…
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…