Search results for " code"
showing 10 items of 636 documents
Histone H3 Lysine 4 Mono-methylation does not Require Ubiquitination of Histone H2B
2005
The yeast Set1-complex catalyzes histone H3 lysine 4 (H3K4) methylation. Using N-terminal Edman sequencing, we determined that 50% of H3K4 is methylated and consists of roughly equal amounts of mono, di and tri-methylated H3K4. We further show that loss of either Paf1 of the Paf1 elongation complex, or ubiquitination of histone H2B, has only a modest effect on bulk histone mono-methylation at H3K4. Despite the fact that Set1 recruitment decreases in paf1delta cells, loss of Paf1 results in an increase of H3K4 mono-methylation at the 5' coding region of active genes, suggesting a Paf1-independent targeting of Set1. In contrast to Paf1 inactivation, deleting RTF1 affects H3K4 mono-methylation…
Glutathione and cellular redox control in epigenetic regulation.
2015
Epigenetics is defined as the mitotically/meiotically heritable changes in gene expression that are not due to changes in the primary DNA sequence. Over recent years, growing evidence has suggested a link between redox metabolism and the control of epigenetic mechanisms. The effect of the redox control, oxidative stress, and glutathione (GSH) on the epigenetic mechanisms occur at different levels affecting DNA methylation, miRNAs expression, and histone post-translational modifications (PTMs). Furthermore, a number of redox PTMs are being described, so enriching the histone code. Pioneer works showed how oxidized GSH inhibits the activity of S-adenosyl methionine synthetase, MAT1A, a key en…
A chromatin-associated protein from pea seeds preferentially binds histones H3 and H4
2002
Pisum sativum p16 is a protein present in the chromatin of ungerminated embryonic axes. The purification of p16 and the isolation of a cDNA clone of psp54, the gene encoding its precursor have been recently reported [Castillo, J., Rodrigo, M. I., Marquez, J. A., Zuniga, A and Franco, L. (2000) Eur. J. Biochem.267, 2156-2165]. In the present paper, we present data showing that p16 is a nuclear protein. First, after subcellular fractionation, p16 was clearly found in nuclei, although the protein is also present in other organelles. Immunocytochemical methods also confirm the above results. p16 seems to be firmly anchored to chromatin, as only extensive DNase I digestion of nuclei allows its r…
RELAP5-3D thermal hydraulic analysis of the target cooling system in the SPES experimental facility
2014
The SPES (Selective Production of Exotic Species) experimental facility, under construction at the Italian National Institute of Nuclear Physics (INFN) Laboratories of Legnaro, Italy, is a second generation Isotope Separation On Line (ISOL) plant for advanced nuclear physic studies. The UCx target-ion source system works at temperature of about 2273 K, producing a high level of radiation (10^5 Sv/h), for this reason a careful risk analysis for the target chamber is among the major safety issues. In this paper, the obtained results of thermofluid-dynamics simulations of accidental transients in the SPES target cooling system are reported. The analysis, performed by using the RELAP5-3D 2.4.2 …
J.C. Maier – ein bereits bekannter Helfer Bluhmes bei der Transkription des Veroneser Codex Iustinianus
2018
J.C. Maier – a previously known aide to Bluhme in the transcription of the Veronese palimpsest of Justinian’s Code. This paper calls into question the idea that in the summer of 1823 Maier worked together with Bluhme at the decipherment of the palimpsest of Gaius’ Institutes preserved in the Capitular Library of Verona (Verona, B. Cap., Cod. XV). A comprehensive analysis of the sources leads to the conclusion that Maier helped Bluhme in the same library for the transcription of the palimpsest of Justinians’ Code (Verona, B. Cap., Cod. LX). – Keywords: Bluhme; Maier; Gaius’ Institutes; Verona, B. Cap., Cod. XV; Codex Iustinianus; Verona, B. Cap., Cod. LX; manuscript studies.
Problemi di giurisdizione nel contrasto al traffico di migranti via mare
2018
I trafficanti di esseri umani si avvalgono con sempre più insistenza di ben collaudati protocolli operativi. Questi ultimi consentono loro di sottrarsi alla giurisdizione penale italiana che non si radica qualora – in ossequio ai criteri di cui all’art. 6 c.p.ed in conformità alla Convenzione sull’Alto Mare– l’azione illecita avvenga in acque internazionali.Così, premesse alcune linee concettuali sui limiti spaziali alla efficacia della legge penale, l’indagine si sofferma sulla soluzione ermeneutica offerta dallaCassazione che, apparentemente in modo sbrigativo e per esigenze di effettività della risposta punitiva, ha fatto ricorso alla controversa figura dell’autore mediato per sanzionare condott…
Das Hypnoseverbrechen. Eine Betrachtung zur Frage der Widerstandsf�higkeit im Sinne des � 179 StGB
1985
Nach der Erorterung verschiedener Hypnosetheorien wird unter Berucksichtigung der physiologischen, psychologischen und behavioristisch-soziologischen Theorie anhand von 5 Fallen die Frage der Willensunfahigkeit im Sinne des § 179 StGB diskutiert und die Widerstandsunfahigkeit verneint.
Statistical learning and multiple linear regression model for network selection using MIH
2014
Award of Appreciation; International audience; A key requirement to provide seamless mobility and guaranteeing Quality of Service in heterogeneous environment is to select the best destination network during handover. In this paper, we propose a new schema for network selection based on Multiple Linear Regression Model (MLRM). A horough investigation, on a huge live data collected from GPRS/UMTS networks led to identify the Key Performance Indicators (KPIs) that play the most important role in the handover process. These KPIs are: Received Signal Code Power (RSCP), received energy per chip (Ec/No) and Available Bandwidth (ABW) of the destination network. To extract a handover model from col…
Temperature and emissivity separation from calibrated data of the Digital Airborne Imaging Spectrometer
2001
Abstract The Digital Airborne Imaging Spectrometer (DAIS), with six thermal infrared channels in the 8–14 μm window, was flown over the Barrax test site, Spain, in the framework of the DAIS Experiment in the summer of 1998. Atmospheric correction of the DAIS thermal channels was performed by means of local radiosonde measurements and a radiative transfer model. Ground measurements of temperature and emissivity for six selected spots (two bare soils, two water bodies, and two vegetated fields) were conducted with the objective of providing calibration and validation targets. Three targets were used for a linear ground calibration of the DAIS thermal channels. With the ground-calibrated image…
Moments and Laws of Large Numbers
2020
The most important characteristic quantities of random variables are the median, expectation and variance. For large n, the expectation describes the typical approximate value of the arithmetic mean (X 1+…+X n )/n of independent and identically distributed random variables (law of large numbers).