Search results for " colon"
showing 10 items of 718 documents
L'angolo come luogo di accumulazione retorica. Balconi e colonne in Sicilia e in Puglia
2013
Il tema prescelto e il termine impiegato nel titolo, cioè la "retorica", si situano in un campo sfuggente: la sfera della rappresentazione e dell'investimento simbolico; temi che non offrono quasi mai risposte documentate e univoche. Non si è infatti in presenza di scelte che soddisfano problemi oggettivi di uso dello spazio e di abitudini costruttive, qui piuttosto si sfiorano ambiti meno storicamente controllabili per i quali è necessario lavorare per ipotesi, per successive approssimazioni e con riferimenti parziali, riconducibili solo a quanto conosciuto direttamente da chi scrive.I casi di voci fuori dal coro (fuori dal classicismo italiano) che si potrebbero portare a esempio sono mol…
Trauma and storytelling in Betty Louise Bell’s Faces in the Moon
2018
The dominant understanding of trauma as an epistemological crisis that can be mimetically passed on to readers has in the twenty-first century been criticized for its apolitical and ahistorical ori...
“A Miracle of Architecture”: The Billiemi limestone Columns of the Church of San Giuseppe dei Teatini in Palermo and Domenico Fontana’s Method for Li…
2014
La chiesa di San Giuseppe dei Teatini di Palermo (costruita a partire dal 1619), è un’architettura singolare nel panorama internazionale del Sei-Settecento. La realizzazione di una spregiudicata conformazione basilicale con copertura a volte, impostata su una sequenza di colonne monolitiche giganti nelle navate e nella crociera con cupola con sostegni alti fino a 10m, è il risultato della convergenza di più fattori. Il conseguimento di questo traguardo si deve alla scoperta nel territorio di Palermo, alla fine del XVI secolo, di un calcare compatto (il “Billiemi”) dalle qualità estetiche e strutturali assimilabili al marmo e in grado di generare poderosi monoliti. Questa opportunità innescò…
Essential Oils as Natural Biocides in Conservation of Cultural Heritage
2020
Essential oils (EOs) have been known for a long time, and they are used in several fields such as medicine and aromatherapy, as well as in the food and pharmaceutical industries. In the last decade, EOs have also been applied to contrast the biodeterioration of cultural heritage, representing a powerful resource in green conservation strategies. In this study, an integrated approach based on microscopic observation, in vitro culture, and molecular investigation was preliminarily employed to identify biological systems colonizing wooden artworks. In order to contrast the biodeterioration processes induced by fungal colonization (Aspergillus flavus) or insect infestation (Anobium punctatum), …
Granulocyte Colony-Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part I): Synthesis and Biodistribution Studies
2018
In the field of cancer immunotherapy, an original approach consists of using granulocyte colony-stimulating factor (G-CSF) to target and activate neutrophils, cells of the innate immune system. G-CSF is a leukocyte stimulating molecule which is commonly used in cancer patients to prevent or reduce neutropenia. We focused herein on developing a G-CSF nanocarrier which could increase the in vivo circulation time of this cytokine, keeping it active for targeting the spleen, an important reservoir of neutrophils. G-CSF-functionalized silica and gold nanoparticles were developed. Silica nanoparticles of 50 nm diameter were functionalized by a solid phase synthesis approach. The technology enable…
A Neuroprotective Function for the Hematopoietic Protein Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)
2007
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine responsible for the proliferation, differentiation, and maturation of cells of the myeloid lineage, which was cloned more than 20 years ago. Here we uncovered a novel function of GM-CSF in the central nervous system (CNS). We identified the GM-CSF α-receptor as an upregulated gene in a screen for ischemia-induced genes in the cortex. This receptor is broadly expressed on neurons throughout the brain together with its ligand and induced by ischemic insults. In primary cortical neurons and human neuroblastoma cells, GM-CSF counteracts programmed cell death and induces BCL-2 and BCL-Xl expression in a dose- a…
Evolution of microbiological and chemical parameters during red wine making with extended post-fermentation maceration.
2014
Abstract The aim of the present work was to investigate the microbiological, chemical, and sensory characteristics of red wine subjected to post-fermentation maceration that was extended to 90 days. For this purpose, the ‘Aglianico di Taurasi’ grape was used as a case study. The total yeast concentration increased until day 40 of maceration and decreased thereafter, whereas the concentration of lactic acid bacteria slightly increased. Dekkera/Brettanomyces spp. and acetic acid bacteria were not detected. The yeast community was composed of Saccharomyces cerevisiae, Zygosaccharomyces bisporus, Metschnikowia pulcherrima, Hanseniaspora guilliermondii, Hanseniaspora uvarum, Pichia guilliermondi…
Two mesalazine regimens in the prevention of the post-operative recurrence of Crohn's disease: a pragmatic, double-blind, randomized controlled trial
2003
Summary Background : The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. Aim : To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantages over 2.4 g/day in the prevention of both endoscopic and clinical post-operative recurrence of Crohn's disease. Methods : The study was a double-blind, randomized, multi-centre, prospective, controlled clinical trial. Two hundred and six patients, submitted to first or second intestinal resection for Crohn's disease limited to the terminal ileum, with or without i…
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
2014
SummaryCancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors. CD44v6 expression is low in primary tumors but demarcated clonogenic CR-CSC populations. Cytokines hepatocyte growth factor (HGF), osteopontin (OPN), and stromal-derived factor 1α (SDF-1), secreted from tumor associated cells, increase CD44v6 expression in CR-CSCs by activating the Wnt/β-catenin pathway, which promotes migration and metastasis. CD44v6− progenitor cells do not give rise to metastatic lesions but, when…