Search results for " colon"
showing 10 items of 718 documents
Biodeterioration
2022
The biodeterioration of organic and inorganic materials, as well as polymers, is a complex of alteration processes induced by the growing and metabolic activity of organisms. It can be recognized on monuments, wall paintings, stone, wood, paper, vegetal/animal fibers, and parchment artworks. As defined by Hueck, 1968, biodeterioration is “any undesirable change in the properties of a material caused by the vital activities of organisms”; this definition is accepted as the meaning of the phenomenon. Both macroorganisms (such as animals, plants, and mosses) and microorganisms (such as autotrophic or heterotrophic bacteria, microfungi, cyanobacteria, algae, and lichens) represent the triggers …
Biocide
2022
Biodeterioration represents a revealing problem for the conservation of cultural heritage. It can be identified as a complex interaction within the ecosystem of a microbial community and its substrate and involves physical and chemical alterations resulting from biological and metabolic activity. Designing a diagnostic approach for evaluating the extent of the damage, identifying the biological community, and opting for an efficient methodology aimed at eliminating deteriogens is equally complicated. The correct approach would require understanding the nature of the biodeterioration and implementing methodologies respectful of human health which, however, avoid the indiscriminate killing of…
Differential recruitment of Angiotensin II receptors in the modulation of rat colonic contractile activity in experimental inflammation
2015
Objective: Inflammatory Bowel Diseases (IBD), are severe gastrointestinal (GI) disorders, with unknown aetiology, characterized by a chronic intestinal inflammatory reaction, progressively affecting GI functions, as gut motility. During inflammatory events, modifications in the functionality of some enteric modulators could contribute to the pathological changes of GI motor patterns. Angiotensin II (Ang II), the main effector of the renin-angiotensin system (RAS), has been recently reported as novel regulator of GI motility, acting on the specific receptors (AT1R and AT2R) located on the gut wall. Since recent studies have pointed out an involvement of RAS system in GI inflammation, we expl…
Opposite effects of dopamine on the mechanical activity of longitudinal and circular muscles in human colon
2015
Objective: Dopamine (DA) has been proposed to act as a modulator of GI motility, via activation of specific receptors D1- and D2-like receptors widely expressed throughout the length of the gastrointestinal tract, in different animal species. However, little and not clear information are available about DA effect in the human gut. The aims of this study were to elucidate whether dopamine may affect contractility in human colon, the receptor subtypes involved and the possible differences in the function and distribution of dopaminergic receptors between longitudinal and circular muscle. Methods: Mechanical responses to dopamine were examined in vitro as changes in isometric tension in strips…
Autophagy and ER-stress participate to cannabinoid-induced apoptosis in colon carcinoma cells
2012
In vitro antitumor effects of the cold-water extracts of Pleurotus eryngii var ferulae and Pleurotus nebrodensis on human colon cancer cells
2013
For centuries, mushrooms have been used as folk medicines especially in Asian countries where their medicinal properties are well known. On the basis of numerous experimental evidences collected in the last decades, the immunomodulatory and anti-neoplastic properties of substances extracted from various species belonging to genera of edible mushrooms [Agaricus L., Auricularia Bull. ex Juss., Ganoderma P. Karst., Grifola Gray, Lentinus Fr., Schizophyllum Fr., Tremella Dill ex L., etc.] are extensively recognized also at scientific levels. Several works have demonstrate that anti-cancer property of these molecules is due to their ability to enhance immune system activity and/or to act directl…
Immunohistochemical and molecular expression of CB1 receptors in human colonic segment. Preliminary results
2011
Recent studies document that CB1 cannabinoid receptors, considered since its first identification as “brain specific”, could be expressed by peripheral tissues targets (adipose organs, enteric nervous system, striated muscle, epatocytes). This receptors were found in the GI tract of different species, including mice, rats, guinea pigs, pigs and humans. Endocannabinoids play a role in the pathophysiology of the gastrointestinal tract. They play a role in emesis, acid-related disorders, motility-related disorders, irritable bowel syndrome and diarrhea, and in inflammatory bowel disease. Endocannabinoid system might be involved in cancer differentiation, growth and cell migration. Distribution…
Ciprofloxacin Polymers Derived from Diallyltin and Divinyltin Dihalides
2008
The initial synthesis of condensation polymers from newly available divinyltin dichloride and diallyltin dichloride and ciprofloxacin is accomplished employing a modified interfacial polycondensation process. The polymeric (DP are about 2,000) products are rapidly (less than 15 seconds) formed in good yield. Infrared spectroscopy shows the formation of Sn-O and Sn-N bonds as predicted from the proposed structure. F-MALDI MS also shows ion fragments containing organotin in the predicted isotopic abundances as well as ion fragments containing both organotin and ciprofloxacin. The polymers exhibit low toxicity towards healthy WI-38 cells with variable toxicities towards a variety of cancer cel…