Search results for " complex"
showing 10 items of 3391 documents
Caratterizzazione geotecnica del comporportamentodi una grande frana in argille varicolori in Sicilia
2014
Si illustrano le misure degli spostamenti e delle pressioni neutre raccolte in un paio d’anni di osservazione del comportamento di un esteso corpo di frana in una formazione di argille varicolori in Sicilia. L’analisi delle misure raccolte indica che la riattivazione riguarda zone distinte del corpo di frana, nelle quali gli spostamenti si sviluppano con velocità e direzioni differenti. L’evoluzione degli spostamenti è manifestamente dipendente dalle condizioni climatiche, dal momento che essi aumentano al crescere delle pressioni interstiziali, a loro volta regolate dalle piogge, e rallentano nella stagione secca, spesso senza annullarsi del tutto. Analisi a ritroso effettuate in una delle…
Novel platinum(II) complexes with heterociclyc ligands: Synthesis and structural chracterization.
2008
An array of mononuclear complexes of Pt(II) with triazine and (benzimidazolyl)pyridine heterocycles is reported. The mononuclear complexes [PtCl2(Kdptdn)] [dbtdn=5,6- diphenyl-3-(2-pyridyl)-1,2,4-triazine-4’,4’’-disulfonate sodium salt hydrate], [PtCl2(bbp)] [bbp=2,6-bis(2-benzimidazolyl)pyridine] and [PtCl2(H2dpt)]PtCl4 [dpt=5,6-diphenyl-3-(2- pyridyl)-1,2,4-triazine] have been prepared and structurally characterized. Both neutral and ionic complexes are present, with bifunctional Pt(II) moieties, whose size and shape enable them to behave as novel scaffolds for DNA binding.
A monumental schola discovered on the Boulevard Frédéric-Latouche in Augustodunum/Autun (Saône-et-Loire)
2013
In 2011, an archaeological evaluation was carried out in the centre of the Roman city of Augustodunum (Autun) on a plot of over 1 ha. This operation afforded the opportunity to explore parts of two insulae along the main street, the so-called cardo maximus, an area that has benefited from recent advances in knowledge. The first insula hosts a high-status domus strongly resembling those of "Balbius Iassus" and the "Étui d’Or", excavated in the vicinity in the 1970s; the second, addressed in this paper, contains the remains of a vast monumental complex covering approximately 900 m2. Most probably built at the beginning of the 2nd c. on the ruins of earlier houses, it was thoroughly restructur…
Ciò che dicono (e non dicono) le Sezioni Unite sul rapporto tra stalking, omicidio aggravato e lesioni aggravate
2022
Le Sezioni Unite hanno chiarito che il reato di omicidio commesso nei confronti della stessa persona offesa del reato di atti persecutori integra un reato complesso. Il presente contributo esamina le conseguenze che questo principio ha sul tema parallelo del rapporto tra il delitto di atti persecutori e il delitto di lesioni personali aggravate perché commesso dall'autore dello stalking nei confronti della stessa vittima. The United Sections have clarified that the crime of homicide committed against the same offended person as the crime of persecutory acts integrates a complex crime. This article examines the consequences that this principle has on the parallel theme of the relationship be…
The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: Implications in rheumatoid…
2009
Objective. Complement activation products contribute to a large number of inflammatory diseases, including RA. We have investigated whether osteoprotegerin (OPG) may concur with the soluble terminal complement complex (SC5b-9) to the inflammatory cascade characterizing RA. Methods. Levels of SC5b-9 and OPG in the plasma and SF of patients with active RA were determined by ELISA. The presence of SC5b-9 and OPG in RA synovial lesions was analysed by immunohistochemistry. Cultured endothelial cells were used for in vitro leucocyte/endothelial cell adhesion assays. In addition, endothelial cells were exposed to SC5b-9 in order to evaluate the effects on the production of OPG protein, as well as…
Dystroglycan regulates structure, proliferation and differentiation of neuroepithelial cells in the developing vertebrate CNS.
2007
AbstractIn the developing CNS α- and β-dystroglycan are highly concentrated in the endfeet of radial neuroepithelial cells at the contact site to the basal lamina. We show that injection of anti-dystroglycan Fab fragments, knockdown of dystroglycan using RNAi, and overexpression of a dominant-negative dystroglycan protein by microelectroporation in neuroepithelial cells of the chick retina and optic tectum in vivo leads to the loss of their radial morphology, to hyperproliferation, to an increased number of postmitotic neurons, and to an altered distribution of several basally concentrated proteins. Moreover, these treatments also altered the oriented growth of axons from retinal ganglion c…
H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove.
1996
The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibilityI-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequencedH2-Ma, H2-Mb1, andH2-Mb2 genes from CIA-susceptible and-resistant mouse strains and identified four differentMa andMb2 alleles and three differentMb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share commonMa, M…
Fertility in McCune Albright syndrome female: A case study focusing on AMH as a marker of ovarian dysfunction and a literature review.
2021
Abstract Background The molecular basis of McCune Albright syndrome (MAS) is a recurrent GNAS Postzygotic gain of function sporadic mutation, resulting in a mosaic disease. Most of girls present precocious puberty, caused by the development of recurrent ovarian cysts with autonomous Hyperestrogenic stimulation. After menarche, the majority of patients with ovarian GNAS mutation have menstrual disturbances and infertility. Objectives We wanted to focus on the fertility of MAS females and propose an appropriate management, by a detailed case report and an exhaustive review of the literature on fertility and pregnancy in MAS females. Results We present the case of a 29-year-old MAS female, who…
Coronary Stent Strut Fractures: Classification, Prevalence and Clinical Associations
2021
Introduction. The frequency, characteristics and clinical implications of Strut fractures (SFs) remain incompletely understood. Methods and results. A total of 185 (160 patients) newer-generation drug-eluting stents (DES) were imaged. SFs were found in 21 DES (11.4%) and were classified in four patterns: one single stacked strut (41%)
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…