Search results for " complex"

Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

2021

The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating th…

On the mechanism of imine elimination from Fischer tungsten carbene complexes

2016

(Aminoferrocenyl)(ferrocenyl)carbene(pentacarbonyl)tungsten(0) (CO)5W=C(NHFc)Fc (W(CO)5(E-2)) is synthesized by nucleophilic substitution of the ethoxy group of (CO)5W=C(OEt)Fc (M(CO)5(1Et)) by ferrocenyl amide Fc-NH– (Fc = ferrocenyl). W(CO)5(E-2) thermally and photochemically eliminates bulky E-1,2-diferrocenylimine (E-3) via a formal 1,2-H shift from the N to the carbene C atom. Kinetic and mechanistic studies to the formation of imine E-3 are performed by NMR, IR and UV–vis spectroscopy and liquid injection field desorption ionization (LIFDI) mass spectrometry as well as by trapping experiments for low-coordinate tungsten complexes with triphenylphosphane. W(CO)5(E-2) decays thermally i…

PHILOSOPHICAL INVESTIGATIONS ON INTEGRATIVE COMPLEXITY

2019

Integrative complexity (IC) refers to a psychological construct, a measurement, and an experience. As a construct IC refers to our less than conscious thinking style in the face of difference or disagreement, how we process information, make decisions, solve problems. The cross-culturally validated empirical measurement frame of IC has predictive values. ’Low IC’ indicates a simple thinking style that is rigid and closed, a ’tunnel vision’ way of thinking that cannot respect or recognize different dimensions or perspectives on a topic, predicting destructive conflict or violence. An increasingly complex thinking style is able to ’see the big picture’, to …

EFFETTI DELLA PROTEZIONE E DELLA COMPLESSITÀ TOPOGRAFICA SUI POPOLAMENTI BENTONICI DEI REEF A VERMETI

2009

Vermetid reef can be considered a key intertidal habitat of Mediterranean Sea and increasing knowledge about this natural system is important for its conservation. Aims of this study is to assess topography complexity, structure and composition of the benthic assemblages associated to reef formation in a marine protected area highlighting possible effects of the protection.

Viral and cellular determinants of hepatitis C virus RNA replication in cell culture.

2003

Studies on the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high level. Analysis of the replicon population in selected cells revealed the occurrence of cell culture-adaptive mutations that enhance RNA replication substantially. To gain a better understanding of HCV cell culture adaptation, we characterized conserved mutations identified by sequence analysis of 26 independent replicon cell clones for their effect on RNA replication. Mutations enhancing replication were found in nearly every nonstructural (NS) protein, and they could be subdivided into at …

Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein

2003

ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…

Visual Methodologies and Geography's education in the pandemic time: notes on geopolitics of migration in the "Mediterranean Complex"

2022

<abstract> <p>The relationship between Geography and the Visual has always been strong intertwined. As it is true that Geography has always operates through images (in the form of pictures, creative representations and above all cartographies), in the last two years, with the distance learning due to the spread of the Covid-19 pandemic, this phenomenon has not only increased, but it also became necessary. "The classroom as the most radical space", in the words of bell hooks, had to turn into a virtual space, where images have a fundamental role in the teaching/learning process. This paper wants to analyse the relationship between Geography and the Visual by analysing three image…

Oscillatory periodic pattern dynamics in hyperbolic reaction-advection-diffusion models

2022

In this work we consider a quite general class of two-species hyperbolic reaction-advection-diffusion system with the main aim of elucidating the role played by inertial effects in the dynamics of oscillatory periodic patterns. To this aim, first, we use linear stability analysis techniques to deduce the conditions under which wave (or oscillatory Turing) instability takes place. Then, we apply multiple-scale weakly nonlinear analysis to determine the equation which rules the spatiotemporal evolution of pattern amplitude close to criticality. This investigation leads to a cubic complex Ginzburg-Landau (CCGL) equation which, owing to the functional dependence of the coefficients here involve…

The complex formation equilibria between Zn(II) and iminodiacetic acid (IDA) in NaClO4 1 M at 25°C

2009

Ground and first excited electronic state interaction of FAD with some β-carboline derivatives

1987

Abstract The spectrophotometric and thermodynamic properties of molecular complexes of flavine adenine dinucleotide (FAD) with some dihydro β-carboline derivatives have been investigated in aqueous solution. The molecular associations have been examined by means of electronic absorption spectra, since in each a new charge-transfer band has been located, and also the variation of the fluorescence emission of FAD on the solutions has been observed. The formation constants for the molecular complexes were determined from absorption data, using the Foster-Hammick-Wardley method. The quenching fluorescence phenomena observed in FAD is related to the concentration of the dihydro β-carboline deriv…