Search results for " complex"
showing 10 items of 3391 documents
Visual category representations in the infant brain
2021
SUMMARYVisual categorization is a human core cognitive capacity1,2that depends on the development of visual category representations in the infant brain3–7. However, the exact nature of infant visual category representations and their relationship to the corresponding adult form remains unknown8. Our results clarify the nature of visual category representations from electroencephalography (EEG) data in 6- to 8-month-old infants and their developmental trajectory towards adult maturity in the key characteristics of temporal dynamics2,9, representational format10–12, and spectral properties13,14. Temporal dynamics change from slowly emerging, developing representations in infants to quickly e…
Digital Resilience to Normal Accidents in High-Reliability Organizations
2021
Digital technologies play a dual role on organizational resilience. On one side, digital systems introduce new technological risks. On the other side, digital systems increase the performances in response to hazardous accidents. Normal Accident Theory (NAT) and High-Reliability Organization (HRO) provide useful ground to explain the dynamics of digital resilience. However, the two theories have been either used as alternatives or with one theory dominating the other. We posit that to fully understand digital resilience we need to integrate NAT and HRO concepts instead of using them in isolation. We conduct a bibliometric analysis to identify major themes and application domains characterizi…
Development of multivariate and network models for the analysis of Big Data: applications in economics, insurance, and social sciences
2020
In questa tesi sviluppo metodi statistici multivariati e di rete per lo studio di sistemi complessi. In particolare, focalizzo la mia analisi sullo studio di reti complesse bipartite e le loro applicazioni a (i) l'economia, per capire l'effetto di contagio tra istituti finanziari e stati sovrani, (ii) la sorveglianza nelle assicurazioni, per individuare comportamenti fraudolenti, e (iii) le scienze sociali, per studiare l'effetto delle politiche del REF sulle eccellenze nella ricerca delle università in UK. In this thesis I develop multivariate statistical and network methods for the study of complex systems. In particular, I focus my analysis on the study of bipartite complex networks and …
Fast Algorithms for Pseudoarboricity
2015
The densest subgraph problem, which asks for a subgraph with the maximum edges-to-vertices ratio d∗, is solvable in polynomial time. We discuss algorithms for this problem and the computation of a graph orientation with the lowest maximum indegree, which is equal to ⌈d∗⌉. This value also equals the pseudoarboricity of the graph. We show that it can be computed in O(|E| √ log log d∗) time, and that better estimates can be given for graph classes where d∗ satisfies certain asymptotic bounds. These runtimes are achieved by accelerating a binary search with an approximation scheme, and a runtime analysis of Dinitz’s algorithm on flow networks where all arcs, except the source and sink arcs, hav…
Optimal standalone data center renewable power supply using an offline optimization approach
2022
Abstract Because of the increasing energy consumption of data centers and their C O 2 emissions, the ANR DATAZERO2 project aims to design autonomous data centers running solely on local renewable energy coupled with storage devices to overcome the intermittency issue. In order to optimize the use of renewable energy and storage devices, a MILP solver is usually in charge of assigning the power to be supplied to the data center. However, in order to reduce the computation time and make the approach scalable, it would be more appropriate to use a polynomial time algorithm. This paper aims at showing and proving that it is possible to provide an optimal power profile via a deterministic algori…
Efficient lower and upper bounds of the diagonal-flip distance between triangulations
2006
There remains today an open problem whether the rotation distance between binary trees or equivalently the diagonal-flip distance between triangulations can be computed in polynomial time. We present an efficient algorithm for computing lower and upper bounds of this distance between a pair of triangulations.
An efficient upper bound of the rotation distance of binary trees
2000
A polynomial time algorithm is developed for computing an upper bound for the rotation distance of binary trees and equivalently for the diagonal-flip distance of convex polygons triangulations. Ordinal tools are used.
Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C&42horbar; sites
1973
Sensitized cells (EA) bearing different numbers of &42horbar; sites were tested for their ability to generate chemotactic activity from C-EDTA. From the results it can be shown that: 1 the amount of chemotactic activity generated parallels the number of &42horbar; sites bound to the cell surface, 2 all &42horbar; sites clustered around a single hemolytic site are enzymatically active as far as generation of chemotactic activity is concerned, and, 3 no difference can be demonstrated with IgG or IgM antibodies
Polyhydroxyethylaspartamide-spermine copolymers: Efficient vectors for gene delivery
2008
Abstract Aim of this paper was that to prepare biocompatible, polyaspartamide based copolymers containing spermine or spermine/hydrophobic side chains able to condense nucleic acids and to transfect mammalian cells. Copolymers were prepared starting from α,β-poly-(N-2-hydroxyethyl)- d , l -aspartamide (PHEA) and exploiting the reactive hydroxyl groups in the polymeric side chains by subsequent activation reactions to obtain PHEA-Spermine (PHEA-Spm) and PHEA-Spermine-Butyramide (PHEA-Spm-C4). Molecular, physico-chemical and biological characterization of copolymers and interpolyelectrolyte complexes with plasmid DNA was performed. Experimental results evidenced that these copolymers are able…
Novel heterobimetallic radiotheranostic: preparation, activity, and biodistribution.
2014
A novel Ru(II) (arene) theranostic complex is presented. It is based on a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the γ emission of (153) Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with ruthenium at the phosphorus atom despite the presence of other functionalities that are prone to metal coordination. Subsequent labeling with radionuclides such as (153) Sm can then be performed easily. The resulting heterobimetallic complex exhibits favorable solubility and stability properties in biologically relevant media. It also shows in vitro cytotoxicity in line with that expected …