Search results for " computing"
showing 10 items of 2075 documents
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Marked systems and circular splicing
2007
Splicing systems are generative devices of formal languages, introduced by Head in 1987 to model biological phenomena on linear and circular DNA molecules. In this paper we introduce a special class of finite circular splicing systems named marked systems. We prove that a marked system S generates a regular circular language if and only if S satisfies a special (decidable) property. As a consequence, we show that we can decide whether a regular circular language is generated by a marked system and we characterize the structure of these regular circular languages.
Creating a sustainable digital infrastructure: The role of service-oriented architecture
2021
Abstract The United Nations’ goal of generating sustainable industry, innovation, and infrastructure is the point of departure for our reflective paper. The paper elaborates on the concepts of digital infrastructure, service-oriented architecture, and microservices. It emphasizes the benefits and challenges of creating a sustainable infrastructure based on a service-oriented environment, in which cloud services constitute an important part. We outline the prerequisites for obtaining a sustainable digital infrastructure based on services. Service-oriented architecture (SOA) and recently, microservice architecture, and cloud services, can provide organizations with the improved agility and fl…
Synchronization in Vehicle Routing—A Survey of VRPs with Multiple Synchronization Constraints
2012
This paper presents a survey of vehicle routing problems with multiple synchronization constraints. These problems exhibit, in addition to the usual task covering constraints, further synchronization requirements between the vehicles, concerning spatial, temporal, and load aspects. They constitute an emerging field in vehicle routing research and are becoming a “hot” topic. The contribution of the paper is threefold: (i) It presents a classification of different types of synchronization. (ii) It discusses the central issues related to the exact and heuristic solution of such problems. (iii) It comprehensively reviews pertinent literature with respect to applications as well as successful s…
CUDA-Accelerated Alignment of Subsequences in Streamed Time Series Data
2014
Euclidean Distance (ED) and Dynamic Time Warping (DTW) are cornerstones in the field of time series data mining. Many high-level algorithms like kNN-classification, clustering or anomaly detection make excessive use of these distance measures as subroutines. Furthermore, the vast growth of recorded data produced by automated monitoring systems or integrated sensors establishes the need for efficient implementations. In this paper, we introduce linear memory parallelization schemes for the alignment of a given query Q in a stream of time series data S for both ED and DTW using CUDA-enabled accelerators. The ED parallelization features a log-linear calculation scheme in contrast to the naive …
Bit-Parallel Approximate Pattern Matching on the Xeon Phi Coprocessor
2014
Bit-parallel pattern matching encodes calculated values in bit arrays. This approach gains its efficiency by performing multiple updates within a machine word. An important parameter is therefore the machine word size (e.g. 32 or 64 bits). With the increasing length of vector registers, the efficient mapping of bit-parallel pattern matching algorithms onto modern high performance computing architectures is becoming increasingly important. In this paper, we investigate an efficient implementation of the Wu-Manber approximate pattern matching algorithm on the Intel Xeon Phi coprocessor. This architecture features a 512-bit long vector processing unit (VPU) as well as a large number of process…
The Reprocessed Proba-V Collection 2: Product Validation
2021
With the objective to improve data quality in terms of cloud detection, absolute radiometric calibration and atmospheric correction, the PRoject for On-Board Autonomy-Vegetation (PROBA-V) data archive (October 2013 - June 2020) will be reprocessed to Collection 2 (C2). The product validation is organized in three phases and focuses on the intercomparison with PROBA-V Collection 1 (C1), but also consistency analysis with SPOT-VGT, Sentinel-3 SYN-VGT, Terra-MODIS and METOP-AVHRR is foreseen. First preliminary results show the better performance of cloud and snow/ice masking, and indicate that statistical consistency between PROBA-V C2 and C1 are in line with expectations. PROBA-V C2 data are …
Adaptive consensus-based distributed detection in WSN with unreliable links
2016
Event detection is a crucial tasks in wireless sensor networks. The importance of a fast response makes distributed strategies, where nodes exchange information just with their one-hop neighbors to reach local decisions, more adequate than schemes where all nodes send observations to a central entity. Distributed detectors are usually based on average consensus, where all nodes iteratively communicate to asymptotically agree on a final result. In a realistic scenario, communications are subject to random failures, which impacts the performance of the consensus. We propose an alternative detector, which adapts to the statistical properties of the consensus and compensate deviations from the …
Introduction—Feelings Matter
2020
Emotions are a hot topic in design, human–computer interaction and any area of business these days. Their significance in areas in which people make choices, decisions and engage in action has been undeniable for at least the last 40 years of psychology and consumer scholarship. What once was an extremely contested, fuzzy and (almost) easily scientifically avoidable area, is now at the centre of everyone’s interest. In an era of cognitive computing, artificial intelligence (so-called learning and thinking machines), and optimization, all attention is placed on what makes us human, and the ways in which human thought actually operates. This emotional logic, intentionality and consciousness i…
Multi-scale analysis of the European airspace using network community detection
2014
We show that the European airspace can be represented as a multi-scale traffic network whose nodes are airports, sectors, or navigation points and links are defined and weighted according to the traffic of flights between the nodes. By using a unique database of the air traffic in the European airspace, we investigate the architecture of these networks with a special emphasis on their community structure. We propose that unsupervised network community detection algorithms can be used to monitor the current use of the airspaces and improve it by guiding the design of new ones. Specifically, we compare the performance of three community detection algorithms, also by using a null model which t…