Search results for " consequence."

Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses

2020

ABSTRACTCoronaviruses may produce severe acute respiratory syndrome (SARS). As a matter of fact, a new SARS-type virus, SARS-CoV-2, is responsible of a global pandemic in 2020 with unprecedented sanitary and economic consequences for most countries. In the present contribution we study, by all-atom equilibrium and enhanced sampling molecular dynamics simulations, the interaction between the SARS Unique Domain and RNA guanine quadruplexes, a process involved in eluding the defensive response of the host thus favoring viral infection of human cells. Our results evidence two stable binding modes involving an interaction site spanning either the protein dimer interface or only one monomer. The …

Engaging in upward and downward comparisons as a determinant of relative deprivation at work

2003

A longitudinal study was conducted among 93 nurses to determine the role of comparing one's performance with that of one's colleagues in the increase versus decrease of perceived relative deprivation at work over a period of one year. Relative deprivation at T2 had increased particularly among those high in social comparison orientation (Gibbons & Buunk, 1999) who at T1 (1) more frequently engaged in upward comparisons; (2) more frequently derived positive as well as negative feelings from such comparisons; and (3) more frequently derived negative feelings from downward comparison. Moreover, engaging in downward comparison also led to an increase in perceived relative deprivation at T2.…

Small changes, big impacts: Geographic expansion in small-scale fisheries

2020

Abstract Small-scale fisheries are an important, yet neglected, millenarian activity that has been undergoing significant changes that threaten its future. Understanding how this activity is spatially distributed and the factors that drive its use of the marine space over time can shed some light on how fishing efforts and their impacts have moved over different parts of coastal marine ecosystems. This study investigated changes to the spatial distribution of small-scale fisheries along the Brazilian equatorial region between 1994 and 2014 and the factors, from ecological to socioeconomic, that influenced this shift. Bayesian hierarchical spatial models were used together with environmental…

Two Paths to Logical Consequence: Pieri and the Peano School

2021

This chapter1 has two main goals. First, it will explore the “negative” avenue leading from the concepts of independence and consistency to that of logical consequence.

Fostering creative thinking : the role of primary teachers

2014

Τα τελευταία χρόνια παρατηρείται μια αυξανόμενη απαίτηση για δημιουργικότητα σε όλους τους τομείς της ανθρώπινης δραστηριότητας. Η πρωτοβάθμια εκπαίδευση πασχίζει να συμβαδίσει με τις νέες κοινωνικοοικονομικές ανάγκες και να προετοιμάσει τους δημιουργικούς πολίτες του μέλλοντος. Αν και οι εκπαιδευτικοί της πρωτοβάθμιας εκπαίδευσης παίζουν καθοριστικό ρόλο, άλλοτε θετικό και άλλοτε αρνητικό, στην καλλιέργεια της δημιουργικότητας των μαθητών, λίγες έρευνες έχουν διεξαχθεί σχετικά με τη συμβολή τους στην καλλιέργεια της δημιουργικής σκέψης των μαθητών και τις απόψεις τους για το θέμα αυτό. Η θεμελιωμένη γνώση (situated knowledge) των Ελλήνων εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης και η εμπειρί…

WHEN DEDUCTION LEADS TO BELIEF

1995

The paper questions the common assumption that rational individuals believe all propositions which they know to be logical consequences of their other beliefs: although we must acknowledge the truth of a proposition which is a deductive consequence of our beliefs, we may not genuinely believe it. This conclusion is defended by arguing that some familiar counterexamples to the claim that knowledge is justified true belief fail because they involve propositions which are not really believed. Beliefs guide conduct or issue in assertion by answering questions which arise in the course of deliberation and conversation, but the troublesome cases present propositions which do not present the agent…

Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity Habits

2020

While the detrimental effects of a chronic positive energy balance due to a sedentary lifestyle have been well established, the impacts of a short period of abruptly reduced physical activity and overeating arising from strict confinement due to the COVID-19 pandemic will soon start to emerge. To reasonably anticipate major consequences according to the available evidence, we hereby review the literature for studies that have explored the health impacts of several weeks of a reduction in physical activity and daily step-count combined with modified eating habits. These studies identify as main metabolic consequences increases in insulin resistance, total body fat, abdominal fat and inflamma…

2021

Young children’s digital media use and physical activity have gained attention in recent research. Parental co-participation has a major impact on children’s health consequences. This study addressed a gap in the research by investigating daily parental co-participation in children’s digital media use and physical play, using the family ecological model theoretical framework. The participants in this nationally representative cross-sectional study were 2512 Finnish parents with two- to six-year-old children. Parents completed a questionnaire. Sociodemographic correlates of co-participation and of the awareness of guidelines regarding co-participation and correlation between co-participation…

The Use of Fear Appeals in Greek Magazine Advertisements

2015

This paper examines fear appeals in Greek magazine advertisements. A total number of 3,262 advertisements were selected from a sample of 14 magazines representing various genre. Advertisements were content analyzed, on the basis of fear appeal categories and consequences. The findings indicate that advertisements use the fear appeal in 16.46 percent of the total number examined. Positive fear appeals and social consequence theme show the highest frequency of appearance with 91.06 and 79.83 percent respectively. There is also a variance in the use of various types of fear appeals, according to magazine classifications and product categories.

A model for estimating the health economic impact of earlier diagnosis of chronic thromboembolic pulmonary hypertension

2021

Background Diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) exceeds 1 year, contributing to higher mortality. Health economic consequences of late CTEPH diagnosis are unknown. We aimed to develop a model for quantifying the impact of diagnosing CTEPH earlier on survival, quality-adjusted life-years (QALYs) and healthcare costs. Material and methods A Markov model was developed to estimate lifelong outcomes, depending on the degree of delay. Data on survival and quality of life were obtained from published literature. Hospital costs were assessed from patient records (n=498) at the Amsterdam UMC – VUmc, which is a Dutch CTEPH referral center. Medication costs were ba…