Search results for " controlled study"

showing 9 items of 19 documents

A randomised controlled study on the use of anti-inflammatory drugs in patients with cancer pain on morphine therapy: effects on dose-escalation and …

2002

The role of non-steroidal anti-inflammatory drugs (NSAIDs) in cancer pain has been well established in the treatment of mild pain and in association with opioids in the treatment of moderate to severe pain. The aim of this study was to verify the effects of NSAIDs on morphine escalation in advanced cancer patients with pain followed-up at home and to assess the pharmacoeconomic implications. A prospective randomised controlled study was carried out in 156 consecutive advanced cancer patients with pain followed-up at home in the period December 1999-December 2000. In this group of patients, 47 were selected with pain progression after 1 week of opioid stabilisation. Patients were randomly as…

MaleCancer ResearchPainHome careDose-escalationNeoplasmsHumansProspective StudiesCancer painAgedRandomised controlled studyAnalysis of VarianceDose-Response Relationship DrugMorphineAnti-Inflammatory Agents Non-SteroidalPalliative CareHematologyPharmacoeconomic analysiMiddle AgedAdvanced cancer patientNSAIDAnalgesics OpioidOncologyDrug Therapy CombinationFemaleFollow-Up StudiesEuropean journal of cancer (Oxford, England : 1990)
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Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Grupp…

2005

BACKGROUND: Although Ki-ras and TP53 mutations have probably been the genetic abnormalities most exhaustively implicated and studied in colorectal cancer (CRC) progression, their significance in terms of disease relapse and overall survival has not yet clearly been established. PATIENTS AND METHODS: A prospective study was carried out on paired tumor and normal colon tissue samples from a consecutive series of 160 previously-untreated patients, undergoing resective surgery for primary operable sporadic CRC. Mutations within the TP53 (exons 5-8) and Ki-ras (exon 2) genes were detected by PCR-SSCP analyses following sequencing. RESULTS: Mutation analyses of exons 5 to 8 of the TP53 gene showe…

MaleOncologyMultivariate analysisColorectal cancerpolymerase chain reactionmedicine.medical_treatmentLeucovorinColorectal Neoplasmmedicine.disease_causeBioinformaticsExonAntineoplastic Combined Chemotherapy ProtocolsProspective Studiesexongene mutationmultivariate analysiProspective cohort studysingle strand conformation polymorphism MeSH: Adenocarcinomaprotein p53 EMTREE medical terms: adultProto-Oncogene ProteinMutationarticleprotein domainclinical trialHematologyMiddle AgedagedItalypriority journalOncologyChemotherapy AdjuvantLymphatic MetastasisDisease ProgressionFemaleFluorouracilColorectal Neoplasmscancer tissueprognosiprospective studyHumansamplingmedicine.medical_specialtyfolinic acidgene sequenceAdenocarcinomarectum carcinomaProto-Oncogene Proteins p21(ras)outcomes researchProto-Oncogene ProteinsInternal medicinemedicineHumanscontrolled studyneoplasmsGeneNeoplasm StagingChemotherapyEMTREE drug terms: fluorouracillevamisoleAntineoplastic Combined Chemotherapy Protocolcontrolled clinical trialbusiness.industryfluorouracil; folinic acid; K ras protein; levamisole; protein p53 adult; aged; article; cancer tissue; clinical trial; codon; colon adenocarcinoma; colorectal surgery; controlled clinical trial; controlled study; exon; gene mutation; gene sequence; human; human cell; human tissue; Italy; major clinical study; male; multivariate analysis; oncology; outcomes research; polymerase chain reaction; prediction; priority journal; prognosis; prospective study; protein domain; rectum carcinoma; sampling; sequence analysis; single strand conformation polymorphism Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy Adjuvant; Colorectal Neoplasms; Disease Progression; Female; Fluorouracil; Humans; Leucovorin; Levamisole; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Mutation; Neoplasm Staging; Prospective Studies; Proto-Oncogene Proteins; ras Proteins; Tumor Suppressor Protein p53 [EMTREE drug terms]human cellLymphatic Metastasipredictionras Proteinmedicine.diseasemajor clinical studyhuman tissueProto-Oncogene Proteins p21(ras)K ras proteinProspective Studiecolon adenocarcinomaMultivariate AnalysisMutationras Proteinscolorectal surgerysequence analysicodonTumor Suppressor Protein p53businessAnnals of Oncology
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Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA‐DR and DQ allele frequency

2007

OBJECTIVE: To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations. METHODS: A total of 116 patients with SSc were classified as diffuse (dSSc) or limited (lSSc), and as carriers of antitopoisomerase I (anti-Scl70) or anticentromere (ACA) antibodies. Allele and genotype frequencies were assessed in the population as a whole and in the two major subsets, dSSc and lSSc. The concentration of peripheral blood immunoglobulin levels was also determined and analysed according to the genotypes. RESULTS: …

MaleSettore MED/16 - REUMATOLOGIAsystemic sclerosisclinical evaluationgenotype phenotype correlationHLA DR antigenSclerodermaGene FrequencyGenotypeImmunology and Allergycentromere antibody; HLA DR antigen; immunoglobulin enhancer binding protein; scl 70 antibody; adult; aged; article; clinical evaluation; controlled study; DNA polymorphism; female; gene frequency; genotype phenotype correlation; human; major clinical study; male; priority journal; risk factor; systemic sclerosis; Adult; Aged; Autoantibodies; Enhancer Elements (Genetics); Esophagus; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DQ Antigens; HLA-DR Antigens; Humans; Immunoglobulin Heavy Chains; Male; Middle Aged; Phenotype; Polymorphism Genetic; Scleroderma Systemic; Statistics Nonparametric; Stomacheducation.field_of_studycentromere antibodyStatisticsStomacharticleMiddle AgedExtended Reportimmunoglobulin enhancer binding proteinEnhancer Elements GeneticPhenotypepriority journalrisk factorFemaleImmunoglobulin Heavy ChainsAdultGenotypeImmunologyPopulationBiologyGeneral Biochemistry Genetics and Molecular BiologyStatistics NonparametricEsophagusGeneticRheumatologyHLA-DQ AntigensHLA-DRHumanscontrolled studyEnhancer Elements (Genetics)NonparametricGenetic Predisposition to DiseasehumanPolymorphismAlleleeducationEnhancerAllele frequencyAgedAutoantibodiesscl 70 antibodyPolymorphism GeneticScleroderma SystemicSystemicHLA-DR Antigensmajor clinical studyGenotype frequencySettore BIO/18 - GeneticaDNA polymorphismImmunologyImmunoglobulin heavy chain
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Plantar flexor activation capacity and H reflex in older adults: adaptations to strength training.

2002

The purpose of this study was to investigate whether the voluntary neural drive and the excitability of the reflex arc could be modulated by training, even in old age. To this aim, the effects of a 16-wk strengthening program on plantar flexor voluntary activation (VA) and on the maximum Hoffman reflex (Hmax)-to-maximum M wave (Mmax) ratio were investigated in 14 elderly men (65–80 yr). After training, isometric maximum voluntary contraction (MVC) increased by 18% ( P < 0.05) and weight-lifting ability by 24% ( P < 0.001). Twitch contraction time decreased by 8% ( P < 0.01), but no changes in half relaxation time and in peak twitch torque were observed. The VA, assessed by twitch …

MaleVolitionAgingPhysiologydegenerationadaptationIsometric exerciseNerve conduction velocityhuman experimentH-ReflexTriceps surae muscleTwitch interpolationadaptation; aged; aging; article; controlled study; degeneration; excitability; exercise; Hoffmann reflex; human; human experiment; male; muscle contraction; muscle isometric contraction; muscle relaxation; muscle twitch; nerve conduction; normal human; plantaris muscle; priority journal; reflex arc; strength; torque; training; voluntary movement; Aging; Exercise; Triceps surae; Twitch interpolationAged 80 and overtrainingvoluntary movementReflex arcarticlereflex arcmusculoskeletal systemAdaptation Physiologicalmuscle twitchmedicine.anatomical_structuremuscle relaxationpriority journalCardiologyTriceps suraemedicine.symptomstrengthMuscle contractionMuscle Contractionmedicine.medical_specialtyWeight Liftingplantaris muscleStrength trainingPhysical exercisePhysical medicine and rehabilitationPhysiology (medical)Internal medicineexcitabilitymedicineHumanscontrolled studyhumannormal humanMuscle SkeletalExercisenerve conductionAgedmuscle isometric contractionbusiness.industrybody regionsHoffmann reflexTorqueH-reflexbusinessJournal of applied physiology (Bethesda, Md. : 1985)
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Patterns of male-specific inter-population divergence in Europe, West Asia and North Africa

2000

summary We typed 1801 males from 55 locations for the Y-specific binary markers YAP, DYZ3, SRY "!)$" and the (CA)n microsatellites YCAII and DYS413. Phylogenetic relationships of chromosomes with the same binary haplotype were condensed in seven large one-step networks, which accounted for 95% of all chromosomes. Their coalescence ages were estimated based on microsatellite diversity. The three largest and oldest networks undergo sharp frequency changes in three areas. The more recent network 3‐1A clearly discriminates between Western and Eastern European populations. Pairwise Fst showed an overall increment with increasing geographic distance but with a slope greatly reduced when compared …

MalehaplotypePopulation geneticsVariation (Genetics)phylogenyAfrica NorthernModelsY Chromosomegenetic variabilitypopulation dynamicsNorthernDinucleotide RepeatsGenetics (clinical)education.field_of_studyPhylogenetic treeGeographyarticlechromosome analysislinguisticsStatisticalEastern europeanEuropeGeographypriority journalMicrosatelliteWesternmarker geneAsiaEvolutionPopulationPopulationmicrosatellite DNA; article; Asia; chromosome analysis; controlled study; Europe; genetic variability; geographic distribution; haplotype; human; linguistics; male; marker gene; normal human; North Africa; phylogeny; population dynamics; priority journal; Africa Northern; Asia Western; Dinucleotide Repeats; Europe; Evolution Molecular; Genetics Population; Geography; Haplotypes; Humans; Male; Microsatellite Repeats; Models Genetic; Models Statistical; Variation (Genetics); Y ChromosomeY chromosomeEvolution MolecularGeneticGeographical distancegeographic distributionAsia WesternGeneticsHumanscontrolled studyhumannormal humaneducationModels StatisticalModels GeneticHaplotypeGenetic VariationMolecularNorth AfricaSettore BIO/18 - GeneticaGenetics PopulationHaplotypesEvolutionary biologyAfricamicrosatellite DNAMicrosatellite Repeats
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Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cance…

2009

CONTEXT: Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC. OBJECTIVE: To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard. DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positiv…

Maleoccult blood testColorectal cancerColonoscopycancer riskprediction and forecastingGastroenterologyRisk Factorscancer diagnosisPositive predicative valueadvanced cancerMedicineFamily historycomparative studycolorectal adenomafamily historyeducation.field_of_studymedicine.diagnostic_testarticleclinical trialGeneral MedicineColonoscopyMiddle Agedpriority journalrisk factorPredictive value of testsdiagnostic accuracyFemalediagnostic valueColorectal NeoplasmsColonography Computed TomographicradiographyComputed TomographicAdultmedicine.medical_specialtySettore MED/12 - GASTROENTEROLOGIAPopulationcolorectal cancerSensitivity and SpecificityPredictive Value of TestsInternal medicineadult; advanced cancer; aged; article; cancer classification; cancer diagnosis; cancer risk; clinical trial; colonoscopy; colorectal adenoma; colorectal cancer; computed tomographic colonography; controlled clinical trial; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; family history; female; human; major clinical study; male; multicenter study; occult blood test; predictive validity; priority journal; colorectal tumor; comparative study; middle aged; prediction and forecasting; radiography; risk factor; sensitivity and specificity; Adult; Aged; Colonography Computed Tomographic; Colonoscopy; Colorectal Neoplasms; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Risk Factors; Sensitivity and Specificitycross-sectional studyHumanscontrolled studyhumaneducationAgedcontrolled clinical trialbusiness.industryFecal occult bloodSigmoidoscopyColonographymedicine.diseasecancer classificationcomputed tomographic colonographymajor clinical studypredictive validitymulticenter studyCross-Sectional StudiesCT colonography colorectal cancer screeningSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusinesscolorectal tumorJAMA
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Prevalence and severity of anaemia in patients with type 2 diabetic nephropathy and different degrees of chronic renal insufficiency.

2007

<i>Background/Aim:</i> Type 2 diabetes mellitus is the single most common cause of chronic kidney disease (CKD); however its real impact on renal anaemia has not been established. The aim of this study was to evaluate whether onset, severity, and prevalence of anaemia during the course of CKD is different between type 2 diabetic and non-diabetic patients. <i>Methods:</i> We enrolled 281 patients with: (1) type 2 diabetes and no CKD (n = 75); (2) type 2 diabetes plus CKD (n = 106), and (3) CKD without type 2 diabetes (n = 100). According to K/DOQI guidelines, the patients with renal insufficiency (i.e., those with a glomerular filtration rate <60 ml/min) were subgr…

NephrologyMaleglomerulus filtration rateType 2 diabetesurologic and male genital diseasesGastroenterologySeverity of Illness Indexadult; aged; anemia; article; chronic kidney failure; comparative study; controlled study; creatinine clearance; diabetic nephropathy; disease course; disease severity; female; glomerulus filtration rate; hemoglobin blood level; human; kidney failure; kidney function; major clinical study; male; non insulin dependent diabetes mellitus; practice guideline; prevalence; priority journal; risk assessment; Aged; Anemia; Creatinine; Diabetes Mellitus Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Kidney Failure Chronic; Male; Middle Aged; Prevalence; Severity of Illness Index; Sex DistributionKidney FailureDiabetic nephropathychemistry.chemical_compoundHemoglobinsChronic kidney diseasecreatinine clearancePrevalenceDiabetic NephropathiesChronickidney functioncomparative studynon insulin dependent diabetes mellitusadultdisease coursearticlerisk assessmentAnemiaGeneral Medicinechronic kidney failureMiddle Agedpriority journalNephrologyCreatininedisease severityFemaleType 2Glomerular Filtration Ratemedicine.medical_specialtyAnaemia diabetes mellitus; Chronic kidney disease diabetes mellitus; Type 2 diabetes mellitus anaemiaRenal functionAnaemiaDiabetes mellitusInternal medicineType 2 diabetes mellitusDiabetes MellitusmedicineHumanscontrolled studyhumanSex DistributionAgedSettore MED/14 - NefrologiaCreatininehemoglobin blood levelbusiness.industrydiabetic nephropathypractice guidelineType 2 Diabetes Mellitusmedicine.diseasemajor clinical studySurgerychemistryDiabetes Mellitus Type 2Kidney Failure ChronicbusinessKidney disease
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Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

2008

Background & Aims Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-β signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-β signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg-mediated suppression. In this study, we have investigated whether IBD mucosal CD4+ T cells are resistant to Tregs and whether Smad7 is involved in this process. Methods IBD lamina propria mononuclear cells …

antisense oligonucleotideCD4-Positive T-LymphocytesAdoptive cell transferT-Lymphocytesanimal cellCell CommunicationInbred C57BLT-Lymphocytes RegulatoryTransgenicMiceregulatory T lymphocyteCrohn DiseaseTransforming Growth Factor betamononuclear cellRAG1 proteinIntestinal MucosaenteritisCells CulturedMice KnockoutSettore MED/12 - GastroenterologiaCulturedintegumentary systemmedicine.diagnostic_testarticleGastroenterologyInterleukinhemic and immune systemsT helper cellColitisRegulatoryUp-Regulationmedicine.anatomical_structurepriority journalgamma interferonSignal TransductionRegulatory T cellColonCellsKnockoutanimal experimentinterleukin 6chemical and pharmacologic phenomenaMice TransgenicBiologyinterleukin 2Recombination-activating geneFlow cytometryProinflammatory cytokineSmad7 ProteinmedicineAnimalsHumanscontrolled studyhumanlamina propriamouseCell ProliferationHomeodomain ProteinsCD4+ T lymphocytenonhumanHepatologyAnimalflow cytometryhuman cellanimal cell culturetransgenic mouseMice Inbred C57BLDisease Models Animalantisense oligonucleotide; gamma interferon; interleukin 17; interleukin 2; interleukin 6; RAG1 protein; Smad7 protein; animal cell; animal cell culture; animal experiment; article; CD4+ T lymphocyte; cell proliferation; colitis; controlled study; enteritis; flow cytometry; human; human cell; knockout mouse; lamina propria; mononuclear cell; mouse; nonhuman; priority journal; regulatory T lymphocyte; transgenic mouse; Animals; CD4-Positive T-Lymphocytes; Cell Communication; Cell Proliferation; Cells Cultured; Colitis; Colon; Crohn Disease; Disease Models Animal; Homeodomain Proteins; Humans; Intestinal Mucosa; Mice; Mice Inbred C57BL; Mice Knockout; Mice Transgenic; Signal Transduction; Smad7 Protein; T-Lymphocytes Regulatory; Transforming Growth Factor beta; Up-RegulationDisease ModelsImmunologyinterleukin 17knockout mouseTransforming growth factorGastroenterology
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Association between osteocalcin and cognitive performance in healthy older adults.

2016

INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor …

cognitionMaleAgingosteopontinvery elderlyCognitive declinesclerostinNeuropsychological Testsolder peopleExecutive FunctionAbsorptiometry PhotonBone Densityblood analysiscognitive defectphoton absorptiometry80 and overcalcium blood leveldickkopf 1 protein25 hydroxyvitamin D; calcium; dickkopf 1 protein; fibroblast growth factor 23; osteocalcin; osteopontin; osteoprotegerin; parathyroid hormone; sclerostin; biological marker; osteocalcin adult; aged; Article; blood analysis; bone density; bone remodeling; calcium blood level; cognition; controlled study; cross-sectional study; dual energy X ray absorptiometry; episodic memory; executive function; female; human; male; neuropsychological test; priority journal; working memory; adolescent; age; aging; blood; clinical trial; cognitive aging; cognitive defect; comparative study; Europe; metabolic bone disease; multicenter study; photon absorptiometry; psychology; sex difference; short term memory; very elderly; young adult Absorptiometry Photon; Adolescent; Adult; Age Factors; Aged; Aged 80 and over; Aging; Biomarkers; Bone Density; Bone Diseases Metabolic; Bone Remodeling; Cognition; Cognition Disorders; Cognitive Aging; Cross-Sectional Studies; Europe; Executive Function; Female; Humans; Male; Memory Episodic; Memory Short-Term; Neuropsychological Tests; Osteocalcin; Sex Factors; Young Adult; Ageing; Cognitive decline; Older people; Osteocalcincomparative studyAged 80 and overdual energy X ray absorptiometryadultAge Factorsclinical trialepisodic memorybiological markerPhotonEuropeagedMemory Short-Termfemalepriority journalyoung adultmetabolic bone diseaseBone RemodelingBone DiseasesEpisodicResearch PaperAdolescentMemory Episodicsex differenceOsteocalcinosteocalcinpsychologyArticleworking memoryfibroblast growth factor 23short term memorySex FactorsbloodMemoryparathyroid hormonecross-sectional studyHumanscontrolled studyhumanAbsorptiometrycalciumcognitive agingcognitive declineBone Diseases MetabolicAgeingikääntyminen25 hydroxyvitamin Dmulticenter studyCross-Sectional StudiesageShort-Termosteoprotegerinneuropsychological testMetabolicOlder peopleCognition DisordersBiomarkers
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