Search results for " cytology"

Parasite eggs in urine cytology: fact or artifact?

2008

Urine sediment cytology should be done for three main reasons: initial evaluation in symptomatic patients, pursuit of patients with tumoral pathology, and risk population screening. Nevertheless, in the course of microscopic observation it is possible to observe several elements or structures that initially seem unrelated to what we are looking for. Schistosomiasis is an endemic disease affecting humans and animals in tropical countries and the Middle and Far East, but infrequent in the developed countries. Typical eggs from Schistosoma are nonoperculate, embryonated when passed in feces and with transparent shell. The eggs are elongate and large in S. mansoni (114–175 3 40– 70 lm in size),…

Urine cytology, tumour markers and bladder cancer

1998

Airway inflammation in patients affected by obstructive sleep apnea syndrome

2004

Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular analysis of the induced sputum. OSAS patients, as compared to control subjects, showed a higher percentage of neutrophils (66.7+/-18.9 vs. 25.8+/-15.6) (P<0.001) and a lower percentage of macrophages (29.4+/-18.4 vs. 70.8+/-15.3) (P<0.001). The percentage of eosinophils and lymphocytes were not significantly different in the two groups. OSAS subjects show bronchial inflammatio…

Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease

2011

Background and Objective. Chronic obstructive pulmonary disease (COPD) is characterized by a persistence of inflammation in large and small airways. We hypothesized that this could be caused by the inability of an inflammatory process to resolve. In the resolution of inflammation, a switching of arachidonic acid metabolism from the production of proinflammatory leukotriene B4 (LtB4) to the synthesis of anti-inflammatory lipoxins plays an important role. The aim of our study was to determine the content of lipoxin A4 (LXA4) and LtB4 in induced sputum of patients with exacerbated COPD and to compare it to healthy controls, as well as to analyze the relationship between proinflammatory and ant…

Nonparenchymal cells in chronically hyperinsulinemic liver acini of diabetic rats, with special regard to hepatic stellate cells

1998

Abstract Background/Aims: An increase in proliferative activity and other distinct hepatocellular alterations — resembling preneoplastic foci and progressing to hepatocellular tumors — have been shown to develop in liver acini draining the blood from islets of Langerhans, transplanted through the portal vein into the liver of streptozotocin-diabetic rats. Methods: Altered and unaltered liver acini were investigated for possible changes in hepatic stellate cells 4–76 days after islet transplantation. Results: Corresponding to a significant increase in the hepatocellular volume, the volume density of total non-parenchymal cells was significantly reduced in altered compared to unaltered liver …

Studies on vinblastine-induced autophagocytosis in mouse liver. III. A quantitative study.

1982

The microtubule inhibitor vinblastine (25 mg/kg, i.p.) induces autophagocytosis in mouse hepatocytes. The formation of autophagic vacuoles, their contents, and other cellular changes after vinblastine injection in hepatocytes, were studied by light and electron microscopic morphometric analysis. The volume density of autophagic vacuoles increased significantly during the experimental period (24 h). This increase was due to the significant increase in their number, which was approximately 5-fold 4 h, 12 h and 24 h after vinblastine injection. The mean volume of the autophagic vacuoles increased significantly 1 h after vinblastine injection, at which time the formation of new autophagic vacuo…

Células del cuello uterino con atipias que no descartan una lesión de alto grado (ASC-H) con premalignidad

2019

Introducción: la presencia de células escamosas con atipias que no descartan una lesión intraepitelial escamosa de alto grado (ASC-H) es significativa, pues cerca de 50% podrían corresponder a una lesión premaligna del cérvix uterino. Objetivo: describir las alteraciones citomorfológicas más frecuentes en los extendidos citológicos categorizados como células escamosas con atipias que no descartan una lesión intraepitelial escamosa de alto grado (ASC-H), con existencia de lesión clínicamente significativa en el resultado histopatológico. Metodología: estudio retrospectivo en el laboratorio de citología de la Facultad de Farmacia y Bioanálisis, Universidad de Los Andes y Clínica de Prevención…

Defective stromal remodeling and neutrophil extracellular traps in lymphoid tissues favor the transition from autoimmunity to lymphoma

2013

Abstract Altered expression of matricellular proteins can become pathogenic in the presence of persistent perturbations in tissue homeostasis. Here, we show that autoimmunity associated with Fas mutation was exacerbated and transitioned to lymphomagenesis in the absence of SPARC (secreted protein acidic rich in cysteine). The absence of SPARC resulted in defective collagen assembly, with uneven compartmentalization of lymphoid and myeloid populations within secondary lymphoid organs (SLO), and faulty delivery of inhibitory signals from the extracellular matrix. These conditions promoted aberrant interactions between neutrophil extracellular traps and CD5+ B cells, which underwent malignant …

Predictive value of positive NMP22 in patients with negative cytology and cystoscopy.

2010

Expression of T-cadherin in tumor cells influences invasive potential of human hepatocellular carcinoma

2006

Overexpression of T-cadherin (T-cad) transcripts occurs in approximately 50% of human hepatocellular carcinomas (HCCs). To elucidate T-cad functions in HCC, we examined T-cad protein expression in normal and tumoral human livers and hepatoma cell lines and investigated its influence on invasive potential of HCC using RNA interference silencing of T-cad expression in Mahlavu cells. Whereas T-cad expression was restricted to endothelial cells (EC) from large blood vessels in normal livers, it was up-regulated in sinusoidal EC from 8/15 invasive HCCs. Importantly, in three of them (38%) T-cad was detected in tumor cells within regions in which E-cadherin expression was absent. Among six hepato…