6533b85cfe1ef96bd12bd478

RESEARCH PRODUCT

Airway inflammation in patients affected by obstructive sleep apnea syndrome

Francesco SalernoE. CarpagnanoA RobertiAntonio M. VignolaAntonio SpanevelloMaria R. BonsignoreMaria AlianiP Guido

subject

MalePulmonary and Respiratory MedicineNeutorphilSputum Cytologymedicine.medical_specialtyPathologyNeutrophilsInflammationGranulocyteGastroenterologyBody Mass IndexLeukocyte CountInternal medicinemedicineHumansInduced sputumBronchitisAgedSleep Apnea Obstructivebusiness.industryMacrophagesSputumSleep apneaOSASMiddle Agedmedicine.diseaserespiratory tract diseasesObstructive sleep apneamedicine.anatomical_structureNeutrophil InfiltrationOSAS; Neutrophils; Induced sputumBronchitisSputumFemalemedicine.symptombusinessBody mass index

description

Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular analysis of the induced sputum. OSAS patients, as compared to control subjects, showed a higher percentage of neutrophils (66.7+/-18.9 vs. 25.8+/-15.6) (P<0.001) and a lower percentage of macrophages (29.4+/-18.4 vs. 70.8+/-15.3) (P<0.001). The percentage of eosinophils and lymphocytes were not significantly different in the two groups. OSAS subjects show bronchial inflammation characterized by a significant increase in neutrophils.

yearjournalcountryeditionlanguage
2004-02-13
10.1016/j.rmed.2003.08.003http://hdl.handle.net/10447/3440