Search results for " damage"
showing 10 items of 1139 documents
Rain on building façades
2006
Rain is one of the main causes of moisture damage to the building envelope, leading to problems such as rain penetration, frost and salt damage, discoloration by leaching, soiling by differential washing, etc. The potential of deterioration due to rain depends on the façade material, the junction of building envelope components, the overall geometry of the building, but also the presence or absence of modulation on the façade. In this paper, Computational fluid dynamics (CFD) simulations are used to analyze these effects and illustrated with examples taken in Sicily. It is firstly shown that buildings protect themselves from driving rain due to the wind blocking effect, but that façade open…
Effect of the serum from multiple sclerosis patients on an in vitro model of blood-brain barrier.
2008
Multiple sclerosis (MS) is characterized by focal inflammatory demyelination, largely due to autoimmune responses against different components of the myelin sheet. It is also generally accepted that the pathogenesis of MS consists of inflammatory and neurodegenerative phases, where demyelination should produce partially reversible clinical deficits that can remit, due to limited remyelination, while axonal degeneration produces permanent non-remitting clinical damage. It is also assumed that nervous system inflammation is initiated by autoreactive, myelin-specific T cells that permeate the blood-brain barrier and trigger a series of events leading to tissue destruction. In addition to antib…
Ultrasound evaluation of joint damage and disease activity in adult patients with severe haemophilia A using the HEAD‐US system
2021
Introduction The Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) system and scoring scale has proven to be an accurate and time-efficient imaging method for identifying joint damage in patients with haemophilia. Aim Observational, multicentre, cross-sectional study conducted in 8 centres in Spain that assessed the joint status of adult patients with severe haemophilia A (SHA) using HEAD-US. Methods Joint status of the elbow, knee and ankle was evaluated in adults with SHA receiving on-demand (OD) treatment, or primary (PP), secondary (SP), tertiary (TP) or intermittent (IP) prophylaxis. Results Of the 95 patients enrolled, 87 received prophylaxis (6.3% PP, 38.9% SP, 43.2% …
Mouse CSB protein is important for gene expression in the presence of a single-strand break in the non-transcribed DNA strand.
2010
CSB protein is required for strand-specific repair of bulky DNA lesions in transcribed genes and mediates transcription recovery after exposure to DNA-damaging agents. We enzymatically generated DNA single-strand breaks (SSBs) with 3'-OH and 5'-phosphate termini in defined positions of a plasmid-borne gene and measured their effect on transcription in cell lines with different statuses of the Csb gene. A single SSB in the transcribed region of the gene caused significant decrease of gene expression. In all tested cell lines of mouse and human origin, a SSB in the transcribed DNA strand was less harmful for gene expression than a SSB situated in the opposing DNA strand. CSB deficiency exhibi…
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA b…
2002
The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated. These combine the deficiency of CSB with that of OGG1, a gene coding for the mammalian repair glycosylase that initiates the base excision repair of 7,8-dihydro-8-oxoguanine (8-oxoG). Compared to ogg1(-/-) mice, csb(-/-)/ogg1(-/-) mice were found to accumulate with age severalfold higher levels of oxidited purine modifications in hepatocytes, splenocytes and kidney cells. In contrast, the basal (ste…
Evaluation of radiological findings with COVID-19 lung lesions in Latvia in the view of artificial intelligence and radiologist
2022
Pēc Pasaules Veselības organizācijas datiem kopš pandēmijas sākuma kopējais ar Covid-19 saslimušo cilvēku skaits pārsniedz 500 miljonus. Mākslīgais intelekts (MI) paver plašas iespējas Covid-19 infekcijas izraisīto plaušu bojājumu diagnostikā, kas var uzlabot un atvieglojot radiologa darbu veicinot gan izmeklējuma specifitātes, gan sensitivitātes izvērtēšanas iespējas. Šī pētījuma galvenais mērķis bija salīdzināt MI un radiologa atradnes precizitāti Covid-19 radītā plaušu bojājuma izvērtēšanā un noteikt interpretācijas ierobežojumus un priekšrocības klīniskā kontekstā. Savukārt darba uzdevumi bija iepazīties un apkopot datus ar jaunāko literatūru par MI pielietošanas iespējām medicīnā. Apko…
Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine
2010
Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…
Il danno non patrimoniale
2022
Il saggio affronta il tema del risarcimento del danno non patrimoniale nella prospettiva della revisione della disciplina del codice civile in materiale. L'autore analizza l'evoluzione della riflessione scientifica sul punto e gli orientamenti della giurisprudenza, tentando la razionalizzazione e l'integrazione delle conclusioni oggi prevalenti. Il saggio si chiude con una proposta di modifica dell'art. 2059 del codice civile. The essay addresses the issue of damages for non-pecuniary loss in the perspective of the revision of the discipline of the civil code in material. The author analyzes the evolution of scientific reflection on this point and the orientations of jurisprudence, attempti…
Decay assessment of stone-built cultural heritage: The case study of the cosenza cathedral façade (south calabria, italy)
2021
This study aims to assess the different decay phenomena affecting the Cosenza Cathedral façade (Calabria, South Italy) through the evaluation of the relative damage indices. For this goal, a multidisciplinary approach was applied exploiting both nondestructive and microdestructive techniques. Such a combination enabled proposing an intervention priority scale that can be helpful to institutions when planning a prompt restoration intervention. The results suggest the efficiency of this approach to obtain a multidisciplinary diagnostic and conservation system for the management and valorization of the Cultural Heritage also in terms of monitoring, maintenance, and selection of the most suitab…
Criteri per l’analisi post-danno – Criteria for post-damage analysis.
2010
Gli elementi non-strutturali risultano assai più vulnerabili al sisma delle strutture, così come reso evidente dai terremoti che nell’ultimo decennio hanno colpito il nostro paese. Il danneggiamento di tali elementi, oltre a mettere a serio rischio la sicurezza degli edifici, e dunque l’incolumità, spesso rende diseconomici, disagevoli o addirittura impraticabili gli interventi di riparazione degli edifici. Ciò anche quando questi sono a struttura intelaiata e progettati e realizzati con criteri antisismici e le strutture non hanno subito danni di rilievo. D’altronde il comportamento sismico degli elementi non strutturali è stato lungamente trascurato e dall’analisi dello stato dell’arte in…