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showing 10 items of 7516 documents

Interreader Reliability of LI-RADS Version 2014 Algorithm and Imaging Features for Diagnosis of Hepatocellular Carcinoma: A Large International Multi…

2017

Purpose To determine in a large multicenter multireader setting the interreader reliability of Liver Imaging Reporting and Data System (LI-RADS) version 2014 categories, the major imaging features seen with computed tomography (CT) and magnetic resonance (MR) imaging, and the potential effect of reader demographics on agreement with a preselected nonconsecutive image set. Materials and Methods Institutional review board approval was obtained, and patient consent was waived for this retrospective study. Ten image sets, comprising 38-40 unique studies (equal number of CT and MR imaging studies, uniformly distributed LI-RADS categories), were randomly allocated to readers. Images were acquired…

medicine.medical_specialtyCarcinoma HepatocellularDatabases FactualIntraclass correlationMedical and Health Sciences030218 nuclear medicine & medical imaging03 medical and health sciencesDatabases0302 clinical medicineClinical ResearchRadiologistsmedicineHumansRadiology Nuclear Medicine and imagingTomographyReliability (statistics)FactualRetrospective StudiesCancerObserver Variationmedicine.diagnostic_testbusiness.industryCarcinomaLiver NeoplasmsReproducibility of ResultsMagnetic resonance imagingRetrospective cohort studyHepatocellularInstitutional review boardMagnetic Resonance ImagingConfidence intervalX-Ray ComputedNuclear Medicine & Medical ImagingPrivate practiceFeature (computer vision)030220 oncology & carcinogenesisBiomedical ImagingCarcinoma Hepatocellular Databases Factual Humans Liver Neoplasms Magnetic Resonance Imaging Observer Variation Radiologists Reproducibility of Results Retrospective Studies Tomography X-Ray Computed AlgorithmsRadiologyTomography X-Ray ComputedbusinessDigestive DiseasesAlgorithms
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A mathematical model of cardiovascular dynamics for the diagnosis and prognosis of hemorrhagic shock

2020

Abstract A variety of mathematical models of the cardiovascular system have been suggested over several years in order to describe the time-course of a series of physiological variables (i.e. heart rate, cardiac output, arterial pressure) relevant for the compensation mechanisms to perturbations, such as severe haemorrhage. The current study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. The present work proposes a first version of a differential-algebraic equations model, the model dynamical ODE model for haemorrhage (dODEg). The model consists of 10 differential and 14 algebraic e…

medicine.medical_specialtyCardiac outputMean arterial pressureShock HemorrhagicSettore ING-INF/01 - ElettronicaCardiovascular SystemGeneral Biochemistry Genetics and Molecular Biologycardiovascular dynamicshemorrhagic shockHeart RateInternal medicineHeart ratemedicineQuantitative assessmentAnimalsmathematical modellingCardiac OutputGeneral Environmental SciencePharmacologyGeneral Immunology and MicrobiologyMathematical modelbusiness.industryApplied MathematicsGeneral NeuroscienceSettore ING-IND/34 - Bioingegneria IndustrialeExperimental dataGeneral MedicineModels Theoreticalhemorrhagic shock;Blood pressureModeling and SimulationSettore ING-INF/06 - Bioingegneria Elettronica E InformaticaHemorrhagic shockCardiologybusinessMathematical Medicine and Biology: A Journal of the IMA
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Measuring physical activity with activity monitors in patients with heart failure: from literature to practice. A position paper from the Committee o…

2020

The aims of this paper were to provide an overview of available activity monitors used in research in patients with heart failure and to identify the key criteria in the selection of the most appropriate activity monitor for collecting, reporting, and analysing physical activity in heart failure research. This study was conducted in three parts. First, the literature was systematically reviewed to identify physical activity concepts and activity monitors used in heart failure research. Second, an additional scoping literature search for validation of these activity monitors was conducted. Third, the most appropriate criteria in the selection of activity monitors were identified. Nine activi…

medicine.medical_specialtyCardiologyPhysical activity610 Medicine & healthHeart failureFitness Trackers030204 cardiovascular system & hematologyMedical and Health Sciences2705 Cardiology and Cardiovascular MedicineExercise Capacity03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitation[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemmedicineHumansCardiac and Cardiovascular SystemsIn patientExercise physiologyAssociation (psychology)Set (psychology)ExerciseMonitoring PhysiologicHeart FailureKardiologiPhysical activitybusiness.industryPhysical activity; Activity monitor; Motion sensor; Accelerometer; Heart failuremedicine.diseaseActivity monitor[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemAccelerometerHeart failure10209 Clinic for CardiologyMotion sensorPosition paperPosition PaperHuman medicineClinical MedicineCardiology and Cardiovascular MedicineRaw databusinessEuropean Journal of Heart Failure
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Cationic lipide mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: Uptake, biological effects and modula…

1996

Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODNs, either alone or in combination with cationic lipids. The uptake of ODNs was enhanced by the use of cationic lipids. In addition, very low concentrations of ODNs in combination with cationic lipids were capable of specifically inhibiting the expression of the c-abl gene. In contrast, no effects were seen on the expression of bcr. However, despite the effective blocking of c-a…

medicine.medical_specialtyCell Membrane PermeabilityChemical PhenomenaMolecular Sequence DataRibonuclease HAntigens CD34BiologyTransfectionPolymerase Chain ReactionCationsProto-Oncogene Proteinshemic and lymphatic diseasesInternal medicineGene expressionmedicineHumansCation Exchange ResinsRNA NeoplasmProto-Oncogene Proteins c-ablGeneCells CulturedOncogene ProteinsABLHematologyBase SequenceCell-Free SystemChemistry PhysicalCell growthCationic polymerizationbreakpoint cluster regionBiological Transporthemic and immune systemsHematologyGeneral MedicineOligonucleotides AntisenseProtein-Tyrosine Kinasesrespiratory systemHematopoietic Stem CellsLipidsMolecular biologyHaematopoiesisGene Expression RegulationDepression ChemicalLiposomesProto-Oncogene Proteins c-bcrAnnals of Hematology
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Differences in zinc status and the leptin axis in anorexic and recovered adolescents and young adults : a pilot study

2012

Food & nutrition research 56, 8 S. (2012). doi:10.3402/fnr.v56i0.10941

medicine.medical_specialtyChild and Adolescent Psychiatry; Medicine;lcsh:TX341-641leptin receptor (sOB-R)leptinanorexia nervosaInternal medicineMedicineddc:610Young adultResearch dataNutrition and DieteticsLeptin receptorbusiness.industryAnorexia nervosa; leptin; leptin receptor (sOB-R); free leptin index (FLI); zincLeptinzincfungidigestive oral and skin physiologyPublic Health Environmental and Occupational HealthControl subjectsfree leptin index (FLI)EndocrinologyAnorexia nervosa (differential diagnoses)Eating disordersOriginal ArticleAnimal studiesNutrition researchbusinesslcsh:Nutrition. Foods and food supplyhormones hormone substitutes and hormone antagonistsFood Science
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Determination of Death in Execution by Lethal Injection in China.

2018

Abstract:Since 1997, execution in China has been increasingly performed by lethal injection. The current criteria for determination of death for execution by lethal injection (cessation of heartbeat, cessation of respiration, and dilated pupils) neither conform to current medical science nor to any standard of medical ethics. In practice, death is pronounced in China within tens of seconds after starting the lethal injection. At this stage, however, neither the common criteria for cardiopulmonary death (irreversible cessation of heartbeat and breathing) nor that of brain death (irreversible cessation of brain functions) have been met. To declare a still-living person dead is incompatible wi…

medicine.medical_specialtyChinaHealth (social science)Insufficient AnesthesiaTissue and Organ ProcurementHeartbeatLevel data030230 surgery0603 philosophy ethics and religionOrgan transplantation03 medical and health sciences0302 clinical medicineLethal InjectionmedicineHumansEthics MedicalSurgical anesthesiaThiopentalCapital Punishmentbusiness.industryHealth Policy06 humanities and the artsPostmortem bloodUnited StatesDeathIssues ethics and legal aspectsOrgan procurementAnesthesiaInjections Intravenous060301 applied ethicsbusinessCambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees
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Recovery of olfaction after sinus surgery for chronic rhinosinusitis: A review

2019

Objective Investigation of the postoperative olfactory function after sinus surgery for chronic rhinosinusitis (CRS) with and without polyps in a review. Data sources PubMed. Review methods A comprehensive literature search was conducted through June 2018 using relevant keywords. The titles/abstracts were reviewed to identify studies evaluating the sense of smell in CRS-patients pre- and postoperatively by either using the whole or parts of the University of Pennsylvania Smell Identification Test or the Sniffin' Sticks test. Study characteristics and outcome data of the included studies were extracted. Results In total, 106 studies were retrieved. Twenty-four studies comprising 1,956 patien…

medicine.medical_specialtyChronic rhinosinusitisAnosmiaOlfaction03 medical and health sciences0302 clinical medicineotorhinolaryngologic diseasesmedicineHumansNasal polypsSinusitis030223 otorhinolaryngologyRhinitisPrior Surgerybusiness.industryRecovery of FunctionSinus surgerymedicine.diseaseSurgeryStudy CharacteristicsSmellOtorhinolaryngology030220 oncology & carcinogenesisChronic Diseasemedicine.symptomOutcome databusinessThe Laryngoscope
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OARSI–OMERACT definition of relevant radiological progression in hip/knee osteoarthritis

2009

Summary Background Joint space width (JSW) evaluated in millimeters on plain X-rays is the currently optimal recognized technique to evaluate osteoarthritis (OA) structural progression. Data obtained can be presented at the group level (e.g., mean±standard deviation of the changes). Such presentation makes difficult the interpretation of the clinical relevance of the reported results. Therefore, a presentation at the individual level (e.g., % progressors) seems more attractive but requires to determining a cut-off. Several methodologies have been proposed to define cut-offs in JSW: arbitrary chosen cut-off, cut-off based on the validity to predict a relevant end-point such as the requiremen…

medicine.medical_specialtyConsensusKnee JointRadiographyBiomedical EngineeringOsteoarthritisCutoffsArticleOsteoarthritis HipRheumatologyReference ValuesReliability studyOsteoarthritisMedicineHumansMedical physicsOrthopedics and Sports MedicineReliability (statistics)Clinical Trials as Topicbusiness.industryEvidence-based medicineOsteoarthritis Kneemedicine.diseaseClinical trialRadiographyRadiological weaponPhysical therapyDisease ProgressionFeasibility StudiesHip JointJoint space widthbusinessMedline databaseOsteoarthritis and Cartilage
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A Systematic Review of Cost-effectiveness Evidence of Endoscopic Saphenous Vein Harvesting: Is it Efficient?

2011

Objective: Greater saphenous vein harvest for coronary and lower extremity bypass requires the longest incision of any surgical procedure. Endoscopic vein harvest allows better results in some clinical variables compared to open harvesting techniques. The objec- tive of this study is to present the results of a systematic review of the scientific evidence about the efficiency of endoscopic saphenous vein harvest. Methods: We performed a systematic review in the bibliographical databases Pubmed, National Health Service Economic Evaluation Database, and NHS Health Technology Assess- ment Database. The search strategy was "endoscopic AND harvesting", in the period January 1970eDecember 2009. R…

medicine.medical_specialtyCost effectivenessCost-Benefit AnalysisGreater saphenous veinEfficiencyScientific evidenceVein harvestingmedicineEconomic evaluation databaseHumansSaphenous VeinEndoscopic harvestMedicine(all)business.industryGeneral surgeryHealth technologyEndoscopyEconomic evaluationSurgeryEconomic evaluationVein harvestTissue and Organ HarvestingSurgerybusinessCardiology and Cardiovascular MedicineVascular Surgical ProceduresEuropean Journal of Vascular and Endovascular Surgery
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Multicentre Study of Chronic Wounds Point Prevalence in Primary Health Care in the Southern Metropolitan Area of Barcelona

2021

Background: Chronic wounds give rise to major costs and resource consumption in health care systems, due to their protracted healing time. Incidence and prevalence data are scarce or nonexistent in community settings. Objective: The aim of the present epidemiological study was to analyse and determine the prevalence of chronic wounds in the community in the south of the province of Barcelona (Spain). Design: A cross-sectional, multicentre secondary data analysis study was conducted in the community (excluding nursing homes) in Barcelona between 16 April and 13 June 2013. It included 52 primary care centres that serve a total population of 1,217,564 inhabitants. Results: The observed prevale…

medicine.medical_specialtyCross-sectional studyLeg ulcerprevalencePrevalencecross-sectional studieslcsh:Medicinevaricose ulcerPressure ulcerArticle030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineEnvironmental healthHealth careEpidemiologymedicinePrevalenceleg ulcer030212 general & internal medicinePrimary health careFoot ulcerpressure ulcerbusiness.industryIncidence (epidemiology)lcsh:RSecondary dataGeneral Medicinemedicine.diseaseMetropolitan areaDiabetic footfoot ulcerprimary health careDiabetic footVaricose ulcerCross-sectional studiesEnfermeríabusinessdiabetic footJournal of Clinical Medicine
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