Search results for " database"
showing 10 items of 684 documents
Metabolic disorders across hepatocellular carcinoma in Italy
2018
Background: Metabolic disorders are well-known risk factors for HCC. Conversely, their impact on the natural history of HCC is not established. This study aimed at evaluating the impact of metabolic disorders on clinical features, treatment and survival of HCC patients regardless of its aetiology. Methods: We analysed the ITA.LI.CA database regarding 839 HCC patients prospectively collected. The following metabolic features were analysed: BMI, diabetes, arterial hypertension, hypercholesterolaemia and hypertriglyceridaemia. According to these features, patients were divided into 3 groups: 0-1, 2 and 3-5 metabolic features. Results: As compared with patients with 0-1 metabolic features, pati…
Evaluation of atezolizumab immunogenicity: Efficacy and safety (Part 2).
2022
Abstract Antibody therapeutics can be associated with unwanted immune responses resulting in the development of anti‐drug antibodies (ADA). Optimal methods to evaluate the potential effects of ADA on clinical outcomes in oncology are not well established. In this study, we assessed efficacy and safety, based on ADA status, in patients from over 10 clinical trials that evaluated the immune checkpoint inhibitor atezolizumab as a single agent or as combination therapy for several types of advanced cancers. ADA can only be observed post randomization, and imbalances in baseline prognostic factors can confound the interpretation of ADA impact. We applied methodology to account for the confoundin…
A Decentralized Ontology Versioning Model Designed for Inter-operability and Multi-organizational Data Exchange
2021
Current information systems operated in a multi-organization context use centralized or hierarchical data models proven inefficient as the network’s scale rapidly increases. The introduction of blockchain and decentralized specific mechanisms stimulate the use of ontology-based data models. While the adoption of blockchain as a communication medium facilitates the communication and data exchange in a more reliably and securely fashion, this opens new challenges regarding the evolution and versioning of the ontology. This paper proposes a versioning mechanism tailored to the decentralized environment. It provides the conceptual building blocks allowing an ontology to evolve under the supervi…
The good, the bad and the ugly – A visual guide for common post-mortem wear patterns in vertebrate teeth
2021
Abstract Dental microwear texture analysis (DMTA) is a common wear proxy using dental wear features to reconstruct diet in extant and extinct taxa. Dietary reconstructions of extinct species can be biased due to post-mortem mechanical modification of the dental surface. These post-mortem surface alterations can be caused by material loss after death, or as the result of burial, excavation, or preparation processes. In this study, we explore post-mortem surface alterations that occur during excavation, preparation, and conservation processes. We present a first general overview of unsuitable and suspicious dental surface scans and describe them both qualitatively and quantitatively using den…
A systematic analysis of evidence for surgically accelerated orthodontics
2019
Background Corticotomy is a technique presumed as useful to decrease the time for orthodontic treatment, however, it is necessary to do a systematic review in order to determine if there is enough scientific evidence to back up the use of Corticotomy to accelerate the treatment. Material and methods Data was stockpiled from the electronic database such as PubMed, Cochrane, Scopus y Science Direct, according to the PRISMA linings for systematic reviews, using the following keywords: accelerated movement of the teeth AND osteotomy AND piezocision AND corticotomy AND orthodontics. Only English, Spanish and French language articles that met the criteria needed were included. Results In the diff…
Coronal joint spaces of the Temporomandibular joint: Systematic review and meta-analysis.
2015
Introduction The joint space measurements of the temporomandibular joint have been used to determine the condyle position variation. Therefore, the aim of this study is to perform a systematic review and meta-analysis on the coronal joint spaces measurements of the temporomandibular joint. Material and Methods An electronic database search was performed with the terms “condylar position”; “joint space”AND”TMJ”. Inclusionary criteria included: tomographic 3D imaging of the TMJ, presentation of at least two joint space measurements on the coronal plane. Exclusionary criteria were: mandibular fractures, animal studies, surgery, presence of genetic or chronic diseases, case reports, opinion or …
Substituted methyl 5β-cholan-24-oates. I—17O NMR spectral characterization
1994
Methyl esters of four common bile acids, 3α-hydroxy-5-β-cholan-24-oic (lithocholic) acid, 3α, 7α-dihydroxy-5β-cholan-24-oic (chenodeoxycholic) acid, 3α,12α-dihydroxy-5β-cholan-24-oic (deoxycholic) acid and 3α,7α,12α-trihydroxy-5β-cholan-24-oic (cholic) acid, and 14 acetylated, trifluoroacetylated, mesylated and oxo derivatives of methyl 5β-cholan-24-oates were prepared and their 17O NMR spectra recorded. In spite of their relatively high molecular masses and the rigid molecular structure of the steroid skeleton, most of the oxygens included in these structures gave well resolved 17O NMR resonance lines at natural abundance in 0.25–0.5 M acetonitrile solutions at 75°C. In agreement with the …
An international perspective on hospitalized patients with viral community-acquired pneumonia
2019
Background Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results 553 (14.9%) patients with CAP underwent nasal swab. Viral CA…
Wykorzystanie zasobów baz danych GIS na potrzeby analizy zróżnicowania obszarów wiejskich w aspekcie działań PROW = Application of GIS databases for …
2018
Realizacja działań w ramach Programu Rozwoju Obszarów Wiejskich (PROW) wymaga obiektywnego rozpoznania potrzeb ich wdrażania, w oparciu o wyniki analiz złożonych procesów przyrodniczych i ekono- miczno-demograficznych zachodzących w czasie i przestrzeni obszarów wiejskich. Wzrastająca funkcjonalność Systemów Informacji Geograficznej (GIS) oraz powszechna dostępność do informacji przestrzennej spowodowały, że bazy danych GIS i analizy geoprzestrzenne stały się skutecznym narzędziem wpierającym implementację działań PROW. Celem pracy jest przedstawienie możliwości wykorzystania danych geoinformacyjnych wybranych baz danych GIS do analizy zróżnicowania przestrzennego obszarów wiejskich wojewód…
Information systems for the conservation and fruition of cultura heritage. The church of Santa Trinità di Delia
2016
Lo studio descrive il processo di conoscenza avviato su uno degli esempi monumentali più rappresentativi dell’architettura normanna della prima metà del XII sec. in Sicilia: la chiesa della Trinità di Delia a Castelvetrano (TP). Le fasi del rilievo e della rappresentazione 3D degli elementi costruttivi e decorativi seguono un approccio parametrico costituendo un sistema informativo implementabile di supporto per successivi interventi di restauro conservativo della struttura. Il workflow è struturato in modo tale da impiegare tecnologie hardware / software low-cost, descrivendo metodiche procedurali di elaborazione dati trasferibili all’attività professionale. The study describes the knowled…