6533b85cfe1ef96bd12bc98f
RESEARCH PRODUCT
An international perspective on hospitalized patients with viral community-acquired pneumonia
Radovanovic DSotgiu GJankovic MMahesh PMarcos PAbdalla MDi Pasquale MGramegna ATerraneo SBlasi FSantus PAliberti SReyes LRestrepo MNoriega LAlvarado EAman MLabra LAruj PAttorri SBarimboim ECaeiro JGarzon MCambursano VCeccato AChertcoff JDiaz ADe Vedia LGanaha MLambert SLopardo GLuna CMalberti AMorcillo NTartara SPensotti CPereyra BScapellato PStagnaro JShah SLotsch FThalhammer FAnseeuw KFrancois CVan Braeckel EVincent JDjimon MNouer SChipev PEncheva MMiteva DPetkova DBalkissou AYone ENgahane BShen NXu JRico CBuitrago RPaternina FNtumba JVladic-carevic VJakopovic MMatkovic ZMitrecic IJacobsson MChristensen ABodtger UMeyer CJensen AEl-wahhab IMorsy NShafiek HSobh EAbdulsemed KBertrand FBrun-buisson CDe Montmollin EFartoukh MMessika JTattevin PKhoury AEbruke BDreher MKolditz MMeisinger MPletz MHagel SRupp JSchaberg TSpielmanns MCreutz PSuttorp NSiaw-lartey BDimakou KPapapetrou DTsigou EAmpazis DKaimakamis EBhatia MDhar RD'souza GGarg RKoul PJayaraj BNarayan KUdnur HKrishnamurthy SKant SSwarnakar RSalvi SLimaye SGolshani KKeatings VMartin-loeches IMaor YStrahilevitz JBattaglia SCarrabba MCeriana PConfalonieri MMonforte ADel Prato BDe Rosa MFantini RFiorentino GGammino MMenzella FMilani GNava SPalmiero GPetrino RGabrielli BRossi PSorino CSteinhilber GZanforlin AFranzetti FCarone MPatella VScarlata SComel AKurahashi KBacha ZUgalde DZuniga OVillegas JMedenica MVan De Garde EMihsra DShrestha PRidgeon EAwokola BNwankwo OOlufunlola AOlumide SUkwaja KIrfan MMinarowski LSzymon SFroes FMeireles MFerrao CLeuschner PNeves JRavara SBrocovschii VIon CRusu DToma CChirita DDorobat CBirkun AKaluzhenina AAlmotairi ABukhary ZEdathodu JFathy AEnani AMohamed NMemon JBella ABogdanovic NMilenkovic BPesut DBorderias LGarcia NAlarcon HCilloniz CTorres ADiaz-brito VCasas XGonzalez AFernandez-almira MGallego MGaspar-garcia IDel Castillo JVictoria PMartinez EDe Molina RMenendez RPando-sandoval AAymerich CDe La Torre AGarcia-olive IRello JMoyano SSanz FSibila ORodrigo-troyano ASole-violan JUranga AVan Boven JTorra EPujol JFeldman CYum HFiogbe AYangui FSemra BilacerogluDalar LYilmaz UBogomolov AElahi NDhasmana DFeneley AHancock CHill ARudran BRuiz-buitrago SCampbell MWhitaker PYouzguin ASinganayagam AAllen KBrito VDietz JDysart CKellie SFranco-sadud RMeier GGaga MHolland TBergin SKheir FLandmeier MLois MNair GPatel HReyes KRodriguez-cintron WSaito SSoni NNoda JHinojosa CLevine SAngel LAnzueto AWhitlow KHipskind JSukhija KTotten VWunderink RShah RMateyo KCarugati MMorosi MMonge EGlimp Study Grpsubject
PNEUMONIAMaleMultivariate analysisInternationalityPCV13 pneumococcal conjugate vaccineDatabases FactualHospitalized patientsmedicine.medical_treatmentvirusesCAD coronary artery diseaseTesting030204 cardiovascular system & hematologyMRSA methicillin resistant Staphylococcus aureusPneumònia adquirida a la comunitatRT-PCR reverse transcriptase polymerase chain reactionchemistry.chemical_compound0302 clinical medicineCommunity-acquired pneumoniaTaverne80 and overCommunity-Acquired InfectionViral030212 general & internal medicineProspective StudiesAged 80 and overRIDT rapid influenza diagnostic testCAP community-acquired pneumoniaRSV Respiratory Syncytial virusMiddle AgedICU intensive care unitCommunity-Acquired InfectionsHospitalizationNasal SwabInfectious diseasesFemaleViral swabHumanOseltamivirmedicine.medical_specialtyLogistic ModelCommunity-acquired pneumoniaViral pneumoniaCommunity acquired pneumonia; Influenza; Oseltamivir; Testing; Viral pneumonia; Viral swab; Aged; Aged 80 and over; Antiviral Agents; Community-Acquired Infections; Cross-Sectional Studies; Databases Factual; Female; Hospitalization; Humans; Influenza Human; Internationality; Logistic Models; Male; Medication Adherence; Middle Aged; Oseltamivir; Pneumonia Viral; Prospective StudiesPneumonia ViralAdmissionSettore MED/10 - Malattie Dell'Apparato RespiratorioInfluenzavirusAntiviral AgentsVirusArticleMedication AdherenceHMPV human MetapneumovirusDatabases03 medical and health sciencesLRTI lower respiratory tract infectionOseltamivirInternal medicineInfluenza HumanInternal MedicinemedicineInfluenza virusesHumansHIV Human Immunodeficiency virusPPSV23 pneumococcal polysaccharide vaccineIn patientFactualAgedMechanical ventilationAntiviral AgentCross-Sectional Studiebusiness.industryFEV1 forced expiratory volume in one secondGLIMP global initiative for methicillin-resistant Staphylococcus aureus pneumoniaESBL extended-spectrum beta-lactamasesPneumoniamedicine.diseaseInfluenzaCommunity acquired pneumoniaCI confidence intervalOR odds ratioCross-Sectional StudiesLogistic ModelschemistryCOPD chronic obstructive pulmonary diseasebusinessCommunity acquired pneumonia ; Influenza ; Oseltamivir ; Testing ; Viral pneumonia ; Viral swabdescription
Background Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-02-01 |