0000000000546405

AUTHOR

Battaglia S

showing 9 related works from this author

Lung penetration and patient adherence considerations in the management of asthma: role of extra fine formulations

2013

Nicola Scichilone, Mario Spatafora, Salvatore Battaglia, Rita Arrigo, Alida Benfante, Vincenzo BelliaDipartimento di Biomedicina e Medicina Interna e Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, ItalyAbstract: The mainstay of management in asthma is inhalation therapy at the target site, with direct delivery of the aerosolized drug into the airways to treat inflammation and relieve obstruction. Abundant evidence is available to support the concept that inflammatory and functional changes at the level of the most peripheral airways strongly contribute to the complexity and heterogeneous manifestations of asthma. It is now largely accepted that there is a wide range …

lcsh:Immunologic diseases. Allergylcsh:RC581-607respiratory tract diseasesJournal of Asthma and Allergy
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The hidden burden of severe asthma: from patient perspective to new opportunities for clinicians

2020

Severe asthma is an important topic in respiratory diseases, due to its high impact on morbidity and mortality as well as on health-care resources. The many challenges that still exist in the management of the most difficult-to-treat forms of the disease, and the acknowledgement of the existence of unexplored areas in the pathophysiological mechanisms and the therapeutic targets represent an opportunity to gather experts in the field with the immediate goals to summarize current understanding about the natural history of severe asthma and to identify gaps in knowledge and research opportunities, with the aim to contribute to improved medical care and health outcomes. This article is a conse…

severe asthmamedicine.medical_specialtySevere asthmaprecision medicineAcknowledgementlcsh:MedicineSocio-culturaleReviewDiseasebiomarkers patient’s perspective precision medicine severe asthma.Medical care03 medical and health sciencesTherapeutic approach0302 clinical medicineMedicine030212 general & internal medicineddc:610Intensive care medicinebusiness.industrylcsh:RPerspective (graphical)General MedicineResearch opportunitiesBiomarkers patient’s perspective precision medicine severe asthmaBiomarkers; Patient’s perspective; Precision medicine; Severe asthmapatient’s perspectiveNatural history030228 respiratory systembusinessBiomarkers
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PREVALENCE OF ARTERIAL HYPERTENSION AND CHARACTERISTICS OF NOCTURNAL BLOOD PRESSURE PROFILE OF ASTHMA PATIENTS ACCORDING TO THERAPY AND SEVERITY OF T…

2020

Background: several studies report an increased risk for asthmatic subjects to develop arterial hypertension and the relationship between these two diseases, frequently co-existing, still has some unclear aspects. Methods: The BADA (blood pressure levels, clinical features and markers of subclinical cardiovascular damage of asthma patients) study is aimed to evaluate the prevalence of the cardiovascular comorbidities of asthma and their impact on the clinical outcome. The main exclusion criteria were the presence of other respiratory diseases, current smoking, any contraindication to ambulatory blood pressure monitoring (ABPM). Results: The overall percentage of asthmatics having also hyper…

cardiovascular riskAdultMalemedicine.medical_specialtyAmbulatory blood pressurePatientsPhysiologyHealth Toxicology and Mutagenesislcsh:MedicineBlood PressureDisease030204 cardiovascular system & hematologyEssential hypertensionSeverity of Illness IndexArticlenocturnal dipping of blood pressure03 medical and health sciences0302 clinical medicineRisk FactorsDiabetes mellitusInternal medicinePrevalenceInternal MedicinemedicineHumans030212 general & internal medicineContraindicationAgedAsthmabusiness.industrylcsh:RPublic Health Environmental and Occupational Healthessential hypertensionOdds ratioasthmaBlood Pressure Monitoring AmbulatoryMiddle Agedmedicine.diseaseNocturnal blood pressureCircadian RhythmNocturnal dipping of blood pressure.Blood pressureHypertensioninhaled corticosteroid therapyFemaleCardiology and Cardiovascular MedicinebusinessBody mass indexJournal of Hypertension
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Management of suspected COVID-19 patients in a low prevalence region

2020

The spread of the SARS-CoV-2 infection among population has imposed a re-organization of healthcare services, aiming at stratifying patients and dedicating specific areas where patients with suspected COVID-related respiratory disease could receive the necessary health care assistance while waiting for the confirmation of the diagnosis of COVID-19 disease. In this scenario, the pathway defined as a “grey zone” is strongly advocated. We describe the application of rules and pathways in a regional context with low diffusion of the infection among the general population in the attempt to provide the best care to respiratory patients with suspected COVID-19. To date, this process has avoided t…

MaleRespiratory Tract DiseasesDiseaseClinical Laboratory Technique0302 clinical medicineCOVID-19 TestingHealth carePrevalence030212 general & internal medicinehealth-care managementeducation.field_of_studyrespiratory symptomsOrganizational InnovationGrey zoneCritical PathwayItalyCritical PathwaysFemaleCoronavirus InfectionsHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PopulationPneumonia ViralContext (language use)Settore MED/10 - Malattie Dell'Apparato RespiratorioDiagnosis Differential03 medical and health sciencesBetacoronavirusmedicineHumansIntensive care medicineeducationPandemicsAgedrespiratory symptomInfection ControlBetacoronavirubusiness.industryCoronavirus InfectionClinical Laboratory TechniquesSARS-CoV-2Hot TopicCOVID-19Patient Care ManagementCOVID-19 Drug Treatment030228 respiratory systemEpidemic outbreakbusinessChronic Respiratory Disease
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La bicicletta sportiva. Caratteristiche geometriche ed inerziali. Simulazione dinamica

2006

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An international perspective on hospitalized patients with viral community-acquired pneumonia

2019

Background Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results 553 (14.9%) patients with CAP underwent nasal swab. Viral CA…

PNEUMONIAMaleMultivariate analysisInternationalityPCV13 pneumococcal conjugate vaccineDatabases FactualHospitalized patientsmedicine.medical_treatmentvirusesCAD coronary artery diseaseTesting030204 cardiovascular system & hematologyMRSA methicillin resistant Staphylococcus aureusPneumònia adquirida a la comunitatRT-PCR reverse transcriptase polymerase chain reactionchemistry.chemical_compound0302 clinical medicineCommunity-acquired pneumoniaTaverne80 and overCommunity-Acquired InfectionViral030212 general & internal medicineProspective StudiesAged 80 and overRIDT rapid influenza diagnostic testCAP community-acquired pneumoniaRSV Respiratory Syncytial virusMiddle AgedICU intensive care unitCommunity-Acquired InfectionsHospitalizationNasal SwabInfectious diseasesFemaleViral swabHumanOseltamivirmedicine.medical_specialtyLogistic ModelCommunity-acquired pneumoniaViral pneumoniaCommunity acquired pneumonia; Influenza; Oseltamivir; Testing; Viral pneumonia; Viral swab; Aged; Aged 80 and over; Antiviral Agents; Community-Acquired Infections; Cross-Sectional Studies; Databases Factual; Female; Hospitalization; Humans; Influenza Human; Internationality; Logistic Models; Male; Medication Adherence; Middle Aged; Oseltamivir; Pneumonia Viral; Prospective StudiesPneumonia ViralAdmissionSettore MED/10 - Malattie Dell'Apparato RespiratorioInfluenzavirusAntiviral AgentsVirusArticleMedication AdherenceHMPV human MetapneumovirusDatabases03 medical and health sciencesLRTI lower respiratory tract infectionOseltamivirInternal medicineInfluenza HumanInternal MedicinemedicineInfluenza virusesHumansHIV Human Immunodeficiency virusPPSV23 pneumococcal polysaccharide vaccineIn patientFactualAgedMechanical ventilationAntiviral AgentCross-Sectional Studiebusiness.industryFEV1 forced expiratory volume in one secondGLIMP global initiative for methicillin-resistant Staphylococcus aureus pneumoniaESBL extended-spectrum beta-lactamasesPneumoniamedicine.diseaseInfluenzaCommunity acquired pneumoniaCI confidence intervalOR odds ratioCross-Sectional StudiesLogistic ModelschemistryCOPD chronic obstructive pulmonary diseasebusinessCommunity acquired pneumonia ; Influenza ; Oseltamivir ; Testing ; Viral pneumonia ; Viral swab
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Are benzodiazepines and opioids really safe in patients with severe COPD?

2015

Breathlessness is a key symptom in chronic obstructive pulmonary disease (COPD) with prognostic implications on health status and survival. Since most conditions underlying chronic refractory breathlessness in COPD are not modifiable, the use of opioids and benzodiazepines has been proposed to relieve it. However, respiratory depression is a known adverse event of these drugs, and concerns have been raised on their use in patients with chronic respiratory failure. Despite safety-related concerns, benzodiazepines are frequently prescribed for a variety of reasons, including treatment of insomnia, depression and anxiety, as well as to relieve refractory dyspnea in patients with COPD. The key …

opioidCOPDbenzodiazepineSettore MED/10 - Malattie Dell'Apparato Respiratorio
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Does the frequency of switching inhalers represent a predictive factor of exacerbation in asthma?

2020

Objective: Management of asthma includes monitoring of inhaler technique and level of adherence to treatment. Both factors could be influenced by high frequency of switching inhaler devices. We explored whether switching inhalers is an independent predictive factor of exacerbations. Methods: Data were collected from 2015 to 2017 from the outpatient clinic of asthma at the University of Palermo, Italy. This observational study consisted of two phases: Phase 1 included subjects of at least three visits in the previous year who reported the frequency of inhalers switched; Phase 2 included subjects of at least two visits during the second year, and the rate of switches and exacerbations was rec…

Pulmonary and Respiratory MedicineAdultmedicine.medical_specialtyExacerbationSettore MED/10 - Malattie Dell'Apparato Respiratorioexacerbation: inhaler03 medical and health sciencesYoung Adult0302 clinical medicineAdrenal Cortex HormonesAdministration InhalationmedicineImmunology and AllergyHumans030212 general & internal medicineAnti-Asthmatic AgentsIntensive care medicinedeviceAsthmaAgedAged 80 and overbusiness.industryInhalerNebulizers and VaporizersMiddle Agedmedicine.diseaseAsthmaswitchPredictive factorHospitalization030228 respiratory systemPediatrics Perinatology and Child Healthbusiness
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Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma

2010

BACKGROUND: Airway inflammation in asthma involves both large and small airways, and the combination of inhaled corticosteroids (ICS) and long acting beta-2 agonists (LABA) is the mainstay of therapy. Available inhaled combinations differ in terms of drug delivery to the lung and the ability to reach small airways. Aim: To evaluate whether treatment with an extra-fine inhaled combination provides additional effects vs a nonextra-fine combination on airway function. METHODS: After a 1- to 4-week run-in period, patients with asthma were randomized to a double blind, double dummy, 12-week treatment with either extra-fine beclomethasone/formoterol (BDP/F) 400/24 microg daily or fluticasone prop…

AdultMaleChemistry PharmaceuticalBeclomethasoneBronchiPilot ProjectsSettore MED/10 - Malattie Dell'Apparato RespiratorioAsthmaFluticasone-Salmeterol Drug CombinationRespiratory Function TestsAndrostadienesDrug CombinationsDouble-Blind MethodEthanolaminesForced Expiratory VolumeFormoterol FumarateAdministration InhalationHumansAsthma Therapy small airwaysAlbuterolFemaleAnti-Asthmatic AgentsMetered Dose InhalersBronchioles
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