6533b82dfe1ef96bd1291477

RESEARCH PRODUCT

PREVALENCE OF ARTERIAL HYPERTENSION AND CHARACTERISTICS OF NOCTURNAL BLOOD PRESSURE PROFILE OF ASTHMA PATIENTS ACCORDING TO THERAPY AND SEVERITY OF THE DISEASE: THE BADA STUDY

Nicola ScichiloneAlida BenfanteAntonino TuttolomondoGiuliana RizzoAntonio PintoDomenico Di RaimondoGaia MusiariBattaglia S

subject

cardiovascular riskAdultMalemedicine.medical_specialtyAmbulatory blood pressurePatientsPhysiologyHealth Toxicology and Mutagenesislcsh:MedicineBlood PressureDisease030204 cardiovascular system & hematologyEssential hypertensionSeverity of Illness IndexArticlenocturnal dipping of blood pressure03 medical and health sciences0302 clinical medicineRisk FactorsDiabetes mellitusInternal medicinePrevalenceInternal MedicinemedicineHumans030212 general & internal medicineContraindicationAgedAsthmabusiness.industrylcsh:RPublic Health Environmental and Occupational Healthessential hypertensionOdds ratioasthmaBlood Pressure Monitoring AmbulatoryMiddle Agedmedicine.diseaseNocturnal blood pressureCircadian RhythmNocturnal dipping of blood pressure.Blood pressureHypertensioninhaled corticosteroid therapyFemaleCardiology and Cardiovascular MedicinebusinessBody mass index

description

Background: several studies report an increased risk for asthmatic subjects to develop arterial hypertension and the relationship between these two diseases, frequently co-existing, still has some unclear aspects. Methods: The BADA (blood pressure levels, clinical features and markers of subclinical cardiovascular damage of asthma patients) study is aimed to evaluate the prevalence of the cardiovascular comorbidities of asthma and their impact on the clinical outcome. The main exclusion criteria were the presence of other respiratory diseases, current smoking, any contraindication to ambulatory blood pressure monitoring (ABPM). Results: The overall percentage of asthmatics having also hypertension was 75% (30 patients) vs. 45% (18 patients) of the control group (p: 0.012). Reduced level of FEV1 (but not inhaled steroid therapy) was associated to newly-diagnosed hypertension (p: 0.0002), higher day SBP levels (p: 0.003), higher day DBP levels (p: 0.03), higher 24 h-SBP levels (p: 0.005) and higher 24h-DBP levels (p: 0.03). The regression analysis performed taking into account sex, age, diabetes, fasting glucose, and body mass index confirms the independent role played by asthma: odds ratio (OR): 3.66 (CI: 1.29&ndash

yearjournalcountryeditionlanguage
2020-09-22Journal of Hypertension
https://doi.org/10.1097/01.hjh.0000745856.56538.1e