Search results for " delay"
showing 10 items of 442 documents
Clonal expansion of melan a-specific cytotoxic T lymphocytes in a melanoma patient responding to continued immunization with melanoma-associated pept…
2000
Peptides derived from human tumor antigens have been used in a number of clinical trials to induce specific immune responses against autologous tumors in cancer patients. Although favorable clinical results were observed in single patients, immune responses correlating with tumor regression were either not detected or in case of responses, the T-cell specificity was difficult to demonstrate. In this study, we analyzed antigen-specific T-cell responses induced in the skin and in peripheral blood lymphocytes (PBL) in an HLA-A2-positive melanoma patient. The patient showed major regression of metastatic melanoma under continued immunization with peptides derived from the melanocyte differentia…
Differences in Kaposi sarcoma-associated herpesvirus-specific and herpesvirus-non-specific immune responses in classic Kaposi sarcoma cases and match…
2011
Kaposi sarcoma (KS) might develop because of incompetent immune responses, both non-specifically and specifically against the KS-associated herpesvirus (KSHV). Peripheral blood mononuclear cells from 15 classic (non-AIDS) KS cases, 13 KSHV seropositives (without KS) and 15 KSHV-seronegative controls were tested for interferon-γ T-cell (enzyme-linked immunospot [Elispot]) responses to KSHV-latency-associated nuclear antigen (LANA), KSHV-K8.1 and CMV/Epstein-Barr virus (EBV) peptide pools. The forearm and thigh of each participant was also tested for delayed-type hypersensitivity (DTH) against common recall antigens. Groups were compared with Fisher exact test and multinomial logistic regress…
Congenital syphilis in a preterm newborn with gastrointestinal disorders and postnatal growth restriction.
2022
Abstract Background Congenital syphilis (CS) depends on the placental transmission of Treponema pallidum (TP) spirochetes from an infected mother to fetus during pregnancy. It shows a wide clinical variability with cutaneous and visceral manifestations, including stillbirths, neonatal death, and asymptomatic cases. Preterm infants with CS may have more severe features of disease than the term ones, due to the combined pathogenic effect of both CS and prematurity. Case presentation We report on a female preterm (32+6 weeks of gestation) newborn showing most of the typical CS manifestations, in addition to gastrointestinal disorders including feeding difficulties, colon stenosis and malabsorp…
Improving the diagnostic approach to celiac disease: Experience from a regional network
2021
Background: Celiac disease (CD) is still underestimated. To close this diagnostic gap, the Health Sicilian Authorities have constituted the "Sicilian Network for CD". Aims: A) To verify the quality of the current diagnostic approach using the data sheet of the Network. B) To evaluate the clinical, serologic and histologic data of new diagnoses in the context of the Network METHODS: We retrospectively evaluated the data collection forms of 369 patients with CD from three Centers within the Sicilian Network. All the Centers used a standard data collection form. Results: A non-classical CD presentation was more frequent than the classical one, anemia being the most frequent symptom (50%). An I…
Maternal cell phone use during pregnancy and child cognition at age 5 years in 3 birth cohorts
2018
Background: There have been few studies of children's cognitive development in relation to mothers' cell phone use, and most were limited to outcomes at age 3 years or younger. We examined the relationship between maternal cell phone use during pregnancy and cognitive performance in 5-year old children. Methods: This study included data from 3 birth cohorts: the Danish National Birth Cohort (DNBC) (n = 1209), Spanish Environment and Childhood Project (INMA) (n = 1383), and Korean Mothers and Children's Environment Health Study (MOCEH) (n = 497). All cohorts collected information about maternal cell phone use during pregnancy and cognitive performance in children at age 5. We performed linea…
Dihydrocucurbitacin B Inhibits Delayed Type Hypersensitivity Reactions by Suppressing Lymphocyte Proliferation
2007
We have studied the effects of dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, on different models of delayed type hypersensitivity (DTH) in mice, as well as on T-lymphocyte proliferation and the mediators involved. In experiments with mice, dihydrocucurbitacin B inhibited the inflammatory reactions induced by oxazolone, dinitrofluorobenzene, and sheep red blood cells, reducing both the edema and cell infiltration. Moreover, the analysis of inflamed tissues showed that dihydrocucurbitacin B reduced the presence of the most relevant cytokines implicated in these processes, including interleukin-1 beta, interleukin-4, and tumor necrosis factor-alpha. Dihydrocucurbita…
Contextual neural-network based spectrum prediction for cognitive radio
2015
Cognitive radio is the technique of effective electromagnetic spectrum usage important for future wireless communication including 5G networks. Neural networks are nature-inspired computational models used to solve cognitive radio prediction problems. This paper presents the use of contextual Sigma-if neural network in prediction of channel states for cognitive radio. Our results indicate that Sigma-if neural network confirms better predictions than Multilayer Perceptron (MLP) network and decreases sensing time for the benefit of the increase of the effectiveness of e-m spectrum usage.
BARGAINING WITH COMMITMENT UNDER AN UNCERTAIN DEADLINE
2006
We consider an infinite horizon bargaining game in which a deadline can arise with positive probability and where players possess an endogenous commitment device. We show that for any truncation of the game, the equilibrium agreement can only take place if the deadline arises within this finite horizon. Since the deadline is an uncertain event, the equilibrium exhibits agreements which are delayed with positive probability.
A Random Trajectory Approach for the Development of Nonstationary Channel Models Capturing Different Scales of Fading
2017
This paper introduces a new approach to developing stochastic nonstationary channel models, the randomness of which originates from a random trajectory of the mobile station (MS) rather than from the scattering area. The new approach is employed by utilizing a random trajectory model based on the primitives of Brownian fields (BFs), whereas the position of scatterers can be generated from an arbitrarily 2-D distribution function. The employed trajectory model generates random paths along which the MS travels from a given starting point to a fixed predefined destination point. To capture the path loss, the gain of each multipath component is modeled by a negative power law applied to the tra…
Doppler Shift Characterization of Wideband Mobile Radio Channels
2019
The prevailing approach for characterizing the Doppler shift (DS) of mobile radio channels assumes the transmission of an unmodulated carrier. This consideration is valid for the analysis of narrowband channels, but its pertinence is questionable in regards to the modeling of wideband channels. In this correspondence, we redefine the DS from a time-frequency analysis perspective that does not depend on the aforementioned assumption. We systematically demonstrate that the DS can be characterized by the instantaneous frequency of the channel transfer function. This generic definition makes evident a fundamental aspect of the DS that is seldom acknowledged, namely, the DS is a frequency-varyin…