Search results for " development"

RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations

2020

Autophagy is dependent on appropriate lipid supply for autophagosome formation. The regulation of lipid acquisition and the autophagy network response to lipid-limiting conditions are mostly elusive. Here, we show that the knockout of the RAB GTPase RAB18 interferes with lipid droplet catabolism, causing an impaired fatty acid release. The resulting reduced lipid-droplet-derived lipid availability influences autophagy and provokes adaptive modifications of the autophagy network. These adjustments include increased expression and phosphorylation of ATG2B as well as augmented formation of the ATG12-ATG5 conjugate. Moreover, ATG9A shows an enhanced phosphorylation at amino acid residues tyrosi…

Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.

2003

International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …

Performance Dissimilarities in European Union Manufacturing: The Effect of Ownership and Technological Intensity

2021

Our paper addresses the relevance of a set of continuous and categorical variables that describe industry characteristics to differences in performance between foreign versus locally owned companies in industries with dissimilar levels of technological intensity. Including data on manufacturing sector performance from 20 European Union member countries and covering the 2009–2016 period, we used the random forests methodology to identify the best predictors of EU manufacturing industries’ a priori classification based on two main attributes: ownership (foreign versus local) and technological intensity. We found that EU foreign-owned businesses dominate locally owned ones in terms of size, wh…

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

2018

Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…

Reading development of late talking toddlers with and without familial risk for dyslexia : a follow up study from age 2 to 15

2015

Expressive language delay is one of the most frequent concerns for parents and health care providers, and it is also one of the most common reasons that young children are referred for evaluation. In the present study, it was examined whether late-talkers with and without familial risk for dyslexia have weaker reading fluency and comprehension at school age (grades 2, 3, 8 and 9) than typically developing, agematched children. The sample of the study was 200 Finnish-speaking children, who were divided into 5 subgroups: 1) Risk Group with no Delay, 2) Risk Group with Expressive Language Delay, 3) Risk Group with Expressive and Receptive Language Delay, 4) Control Group with Expressive Langua…

Correlates of Orthographic Learning in Swedish Children With Cochlear Implants

2019

This study set out to explore the cognitive and linguistic correlates of orthographic learning in a group of 32 deaf and hard of hearing children with cochlear implants, to better understand the factors that affect the development of fluent reading in these children. To date, the research about the mechanisms of reading fluency and orthographic learning in this population is scarce. The children were between 6:0 and 10:11 years of age and used oral language as their primary mode of communication. They were assessed on orthographic learning, reading fluency and a range of cognitive and linguistic skills including working memory measures, word retrieval and paired associate learning. The resu…

Albanian students’ motives for preferring certain real-life situations for learning mathematics

2011

This article reports on a qualitative investigation of Albanian students’ motives for preferring certain real-life situations to be used in school mathematics, and possible connections of these motives to characteristics and issues within Albanian society. It is based on realistic interviews with students from Grades 8 and 9 in a school in the district of Shkodra in northern Albania. Interviews were conducted after students experienced five teaching units which dealt with mathematics embedded in real-life situations. Results are expressed in terms of contextmechanism-outcome configurations as proposed by critical realist theory. Most of the resultsare supported by those from a previous quan…

Moral development & reality. beyond the theories of Kohlberg, Hoffman, and Haidt

2013

Influence of brand image of a sports event on the recommendation of its participants

2020

The aim of this research is to test the psychometric properties and relationships of a model where, from brand congruence of a sport event, trust and commitment to it can be generated, influencing future behavior of participants and resulting in a higher recommendation also called Word of Mouth (hereinafter WOM). A quantitative approach has been carried out by means of a validated questionnaire with Likert-type responses, and data were analyzed with the EQS 6.4 software. The findings indicated that the model is adequate, and also confirm that from congruence, we can explain, at a theoretical level, 45% of trust, and in the same way, from the congruence and trust, we can explain 67% of the c…

TISSBERT: A benchmark for the validation and comparison of NDVI time series reconstruction methods

2018

[EN] This paper introduces the Time Series Simulation for Benchmarking of Reconstruction Techniques (TISSBERT) dataset, intended to provide a benchmark for the validation and comparison of time series reconstruction methods. Such methods are routinely used to estimate vegetation characteristics from optical remotely sensed data, where the presence of clouds decreases the usefulness of the data. As for their validation, these methods have been compared with previously published ones, although with different approaches, which sometimes lead to contradictory results. We designed the TISSBERT dataset to be generic so that it could simulate realistic reference and cloud-contaminated time series …