Search results for " display"
showing 10 items of 225 documents
Molecular Design of the Cαβ Interface Favors Specific Pairing of Introduced TCRαβ in Human T Cells
2008
Abstract A promising approach to adoptive transfer therapy of tumors is to reprogram autologous T lymphocytes by TCR gene transfer of defined Ag specificity. An obstacle, however, is the undesired pairing of introduced TCRα- and TCRβ-chains with the endogenous TCR chains. These events vary depending on the individual endogenous TCR and they not only may reduce the levels of cell surface-introduced TCR but also may generate hybrid TCR with unknown Ag specificities. We show that such hybrid heterodimers can be generated even by the pairing of human and mouse TCRα- and TCRβ-chains. To overcome this hurdle, we have identified a pair of amino acid residues in the crystal structure of a TCR that …
In vivophage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues
2020
ABSTRACTIn vivophage display is widely used for identification of organ- or disease-specific homing peptides. However, the currentin vivophage biopanning approaches fail to assess biodistribution of specific peptide phages across tissues during the screen, thus necessitating laborious and time-consuming post-screening validation studies on individual peptide phages. Here, we adopted bioinformatics tools used for RNA sequencing for analysis of high throughput sequencing (HTS) data to estimate the representation of individual peptides during biopanningin vivo. The data fromin vivophage screen were analyzed using differential binding – relative representation of each peptide in the target orga…
A Novel Zeolite-Induced Population of a Planar Viologen Conformation. New Viologen Charge Transfer Complexes and Alkene/Viologen/Zeolite Arrays
2004
A rare example of a novel zeolite-induced conformational change and a mechanism for this process are suggested in order to rationalize an unexpected spontaneous intrazeolite reduction observed during preparation of a new viologen (MQ2+)-doped zeolite (NaY). In addition, the formations of six new alkene/viologen/ zeolite charge transfer (CT) arrays using NaMQY and the previously reported NaMVY are also reported. The binding constants between MQ2+ and MV2+ and 2,3-dimethyl-2-butene (TME) were determined using the Benesi-Hildebrand approach, and the stabilities of these CT complexes are compared to their intrazeolite analogue.
The influence of virtual reality in e-commerce
2019
[EN] The development of virtual reality (VR), together with other technological innovations will shape the future of e-retailing. This research studies the effectiveness of different VR formats and devices in a virtual store environment, namely V-commerce. This study proposes and test a conceptual model that analyses the relations between sense of presence, brand recall and purchase intention, while also going deeper into their antecedents. Our findings suggest differences in purchase intention depending on VR format and device used. No differences are shown in sense of presence and affect by VR format and device. Our tested model suggests a dual route of influence of VR on consumers' purch…
Smadzeņu aktivitāte un volumetriskais ekrāns
2020
Maģistra darbs uzrakstīts angļu valodā uz 32 lappusēm. Tas satur 15 attēlus un ir atsauces uz 37 literatūras avotiem. Strauji attīstoties trīsdimensiju (3D) vizualizācijas tehnoloģijai ir nepieciešams precīzi novērtēt cilvēka spēju pielāgoties tai. Šādos pētījumos plaši tiek izmantots EEG. Pētījuma mērķis bija izpētīt smadzeņu aktivitātes īslaicīgās izmaiņas, skatoties uz volumetriskiem attēliem un salīdzinot ar anaglifa 3D attēlu aplūkošanu. Uzdevums bija noteikt tuvāk esošo apli starp četriem projicētiem apļiem. Smadzeņu aktivitātes signālu reģistrēšanai tika izmantots EEG. Izsaukto potenciālu P300 komponentē darba slodzes ietekmē netika novērotas būtiskas izmaiņas. Būtiskas izmaiņas tika…
Visual Distraction Effects between In-Vehicle Tasks with a Smartphone and a Motorcycle Helmet-Mounted Head-Up Display
2018
Besides motorists, also motorcyclists need safer user interfaces to interact with useful applications on the road. In this paper, distraction effects of in-vehicle tasks conducted with a head-up display (HUD) for motorcyclists were compared to smartphone tasks with 24 participants in a driving simulator. Compared to the smartphone tasks, the head-up display tasks decreased the percentage of inappropriately long glances by 45 percent. The head-up display tasks were also experienced as less demanding than the smartphone tasks. Additionally, the use of head-up display for navigation did not lead to gaze concentration effects compared to baseline driving. The head-up display is concluded to be …
Ergonomic Comparison of a Sit-Stand Workstation With a Traditional Workstation in Visual Display Unit Work
2013
Purpose: To compare ergonomics of an electrically adjustable sit-stand workstation with a traditional workstation in video display unit (VDU) work. Methods: Twelve female workers (aged 27-53 years) participated in this experimental study. Electromyography, wrist postures, subjective assessments, and productivity were used to make the ergonomic comparison. Results: The muscle activity of the right trapezius (p=0.01) and left wrist extensors (p=0.02), extension of the right (p=0.05) and left (p=0.002) wrist, and perceived strain of the arms (p=0.05) were lower and productivity was better (p=0.02) when the workers used a low-sitting, high-sitting, or standing posture at the sit-stand workstati…
Video display terminal use and dry eye: preventive measures and future perspectives
2022
Background: Dry eye disease (DED) is a common cause of ocular pain and discomfort. Dry eye disease (DED) stems from a loss-of-tear film homeostasis and is frequently seen in video display terminal (VDT) users. Video display terminal (VDT) use reduces blink rates and increases incomplete blinks, leading to tear film instability and ocular inflammation, promoting DED. Purpose: To assess and evaluate the methods for preventing VDT-associated DED and ocular discomfort. Methods: Studies were found using PubMed and Embase with the search terms: (digital visual terminal* OR computer use OR screen use OR smartphone OR display OR visual display terminal* OR computer vision syndrome OR tablet OR phon…
When virtual and real worlds coexist: Visualization and visual system affect spatial performance in augmented reality
2021
New visualization approaches are being actively developed aiming to mitigate the effect of vergence-accommodation conflict in stereoscopic augmented reality; however, high interindividual variability in spatial performance makes it difficult to predict user gain. To address this issue, we investigated the effects of consistent and inconsistent binocular and focus cues on perceptual matching in the stereoscopic environment of augmented reality using a head-mounted display that was driven in multifocal and single focal plane modes. Participants matched the distance of a real object with images projected at three viewing distances, concordant with the display focal planes when driven in the mu…
Effects of menu structure and touch screen scrolling style on the variability of glance durations during in-vehicle visual search tasks.
2011
The effects of alternative navigation device display features on drivers' visual sampling efficiency while searching forpoints of interest were studied in two driving simulation experiments with 40 participants. Given that the number of display items was sufficient, display features that facilitate resumption of visual search following interruptions were expected to lead to more consistent in-vehicle glance durations. As predicted, compared with a grid-style menu, searching information in a list-style menu while driving led to smaller variance in durations of in-vehicle glances, in particular with nine item displays. Kinetic touch screen scrolling induced a greater number of very short in-v…