Search results for " early"

showing 10 items of 329 documents

Clinical features and follow-up in patients with 22q11.2 deletion syndrome

2014

Objective To investigate the clinical manifestations at diagnosis and during follow-up in patients with 22q11.2 deletion syndrome to better define the natural history of the disease. Study design A retrospective and prospective multicenter study was conducted with 228 patients in the context of the Italian Network for Primary Immunodeficiencies. Clinical diagnosis was confirmed by cytogenetic or molecular analysis. Results The cohort consisted of 112 males and 116 females; median age at diagnosis was 4 months (range 0 to 36 years 10 months). The diagnosis was made before 2 years of age in 71% of patients, predominantly related to the presence of heart anomalies and neonatal hypocalcemia. In…

MalePediatrics22q11.2 deletionDelayed DiagnosisTime FactorsChromosomes Human Pair 22Developmental Disabilitiesdigeorge syndromeSex FactorSeverity of Illness IndexRetrospective StudieDiGeorge syndromeEarly DiagnosiAge FactorProspective StudiesNeonatal hypocalcemiaProspective cohort studyChildmedicine.diagnostic_testDelayed Diagnosi22q11.2 deletion; Primary immune disordersAge Factorsdel 22qMIMAbnormalities Multiple; Adolescent; Adult; Age Factors; Child; Child Preschool; Chromosomes Human Pair 22; Delayed Diagnosis; Developmental Disabilities; DiGeorge Syndrome; Early Diagnosis; Female; Follow-Up Studies; Genetic Testing; Humans; Infant; Infant Newborn; Male; Monitoring Physiologic; Prospective Studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Young Adult; Disease ProgressionChild PreschoolCohortDisease ProgressionPrimary immune disordersFemaleAbnormalitiesMultipleAbnormalities Multiple; Adolescent; Adult; Age Factors; Child; Child Preschool; Chromosomes Human Pair 22; Delayed Diagnosis; Developmental Disabilities; DiGeorge Syndrome; Early Diagnosis; Female; Follow-Up Studies; Genetic Testing; Humans; Infant; Infant Newborn; Male; Monitoring Physiologic; Prospective Studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Young Adult; Disease Progression; Pediatrics Perinatology and Child HealthHumanAdultmedicine.medical_specialtyTime FactorAdolescentMonitoringDevelopmental DisabilitieItalian Association of Pediatric Haematology and OncologyContext (language use)Risk AssessmentChromosomesFollow-Up StudieYoung AdultSex FactorsSeverity of illnessmedicineDiGeorge SyndromeHumansAbnormalities MultipleGenetic Testing22q11DS; 22q11.2 deletion syndrome; AIEOP; Italian Association of Pediatric Haematology and Oncology; MIM; Mendelian Inheritance in Man22q11DSPreschoolPhysiologicdigeorge syndrome; del 22qGenetic testingMonitoring PhysiologicRetrospective StudiesSettore MED/38 - Pediatria Generale e Specialisticabusiness.industryMendelian Inheritance in ManInfant NewbornInfantRetrospective cohort studymedicine.diseaseNewbornAIEOPProspective StudieEarly Diagnosis22q11.2 deletion syndromePediatrics Perinatology and Child HealthPair 22businessFollow-Up Studies
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Stimulation of immediate early gene expression by desipramine in rat brain.

1997

The stimulation of immediate early gene expression in brain and neuronal cell culture systems has been reported after various experimental paradigms such as chemiconvulsant-provoked seizures or specific drug applications. In particular, the induction of immediate early genes by adrenergic model substances has been demonstrated by several investigators. This report demonstrates that a single dose of desipramine (10 or 25 mg/kg), a classical tricyclic antidepressant drug acting on the adrenergic system, induced c-fos and zif268 expression in rat hippocampus without affecting c-jun. The observed immediate early gene response might reflect part of a signal transduction cascade involved in long-…

MaleProto-Oncogene Proteins c-junAdrenergicStimulationPharmacologyBiologyAntidepressive Agents Tricyclicc-FosHippocampusPolymerase Chain ReactionImmediate-Early ProteinsRats Sprague-DawleyDesipraminemedicineAnimalsRNA MessengerGenes Immediate-EarlyBiological PsychiatryEarly Growth Response Protein 1Regulation of gene expressionBrain Chemistryc-junDesipramineStimulation ChemicalRatsDNA-Binding ProteinsGene Expression Regulationbiology.proteinLocus CoeruleusSignal transductionOligonucleotide ProbesImmediate early geneNeuroscienceProto-Oncogene Proteins c-fosmedicine.drugTranscription FactorsBiological psychiatry
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Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity

2013

BACKGROUND: Pollen-induced allergic rhinoconjunctivitis (AR) is highly prevalent and rapidly evolving during childhood. General practitioners may not be fully aware of the nature and severity of symptoms experienced by patients and might underestimate the prevalence of moderate or severe disease. Thus, the relevance of early diagnosis and intervention may be overlooked. OBJECTIVES: To investigate the severity of pollen-induced AR and its determinants in Italian children referred to allergy specialists and who had never received specific immunotherapy (SIT). METHODS: Children (age 4-18 yr) affected by pollen-induced AR who had never undergone SIT were recruited between May 2009 and June 2011…

MaleQuestionnairesAllergyPediatricsmultiple pollen sydromemultiple pollen syndromeBreastfeedingComorbidityAirborne allergenSurveys and QuestionnairesEpidemiologyPrevalenceImmunology and AllergyOutpatient clinicAge of OnsetChildConjunctivitis AllergicRhinitispan-allergens; multiple pollen syndrome; profilin; asthma; children; allergic rhinitis; epidemiology; italy; allergic conjunctivitisEnvironmental exposuremultiple pollen syndrome; Humans; profilin; Disease Progression; children; Child; Italy; Comorbidity; pan-allergens; Allergens; asthma; Male; Antigens Plant; Questionnaires; Age of Onset; Conjunctivitis Allergic; Skin Tests; epidemiology; Pollen; Child Preschool; Rhinitis Allergic Seasonal; allergic rhinitis; Early Diagnosis; allergic conjunctivitis; Female; PrevalenceAllergic conjunctivitisItalypan-allergensChild PreschoolpanallergenDisease ProgressionPollenepidemiologyFemaleallergic rhinitimedicine.medical_specialtyItaly; allergic conjunctivitis; allergic rhinitis; asthma; children; epidemiology; multiple pollen syndrome; pan-allergens; profilinImmunologyAllergicchildrenmedicineHumansprofilinallergic conjunctivitiAntigensPreschoolAsthmaSkin TestsSettore MED/38 - Pediatria Generale e SpecialisticaSeasonalallergic rhinitisbusiness.industryallergic rhinitis; allergic conjunctivitis; asthma; children; epidemiology; Italy; multiple pollen syndrome; pan-allergens; profilinRhinitis Allergic SeasonalPlantAntigens PlantAllergensasthmamedicine.diseaseConjunctivitispan-allergenallergic conjunctivitisEarly DiagnosisPediatrics Perinatology and Child Healthbusiness
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Is high-sensitivity troponin, alone or in combination with copeptin, sensitive enough for ruling out NSTEMI in very early presenters at admission? A …

2019

Objectives: Copeptin and high-sensitivity cardiac troponin (HS-cTn) assays improve the early detection of non-ST-segment elevation myocardial infarction (NSTEMI). Their sensitivities may, however, be reduced in very early presenters.Setting: We performed a post hoc analysis of three prospective studies that included patients who presented to the emergency department for chest pain onset (CPO) of less than 6 hours.Participants: 449 patients were included, in whom 12% had NSTEMI. CPO occurred 4 hours in 146 patients. The prevalence of NSTEMI was similar in all groups (9%, 13% and 12%, respectively, p=0.281).Measures: Diagnostic performances of HS-cTn and copeptin at presentation were examined…

MaleTime Factors030204 cardiovascular system & hematologyChest pain0302 clinical medicinehigh sensitive cardiac troponinTroponin IMedicine1506Prospective Studies030212 general & internal medicineMyocardial infarctionNon-ST Elevated Myocardial InfarctionProspective cohort studynon st-elevation acute myocardial infarction[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyTroponin TRGlycopeptidesGeneral MedicineMiddle Aged3. Good healthchest pain onsetEmergency MedicineCardiologyMedicineFemalevery early presentersmedicine.symptomEmergency Service HospitalAdultmedicine.medical_specialtychest pain03 medical and health sciencesCopeptinPredictive Value of TestsInternal medicinePost-hoc analysisHumansAgedbusiness.industryResearchTroponin IcopeptinEmergency departmentmedicine.disease1691businessBiomarkers[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Peer reports of adaptive behavior in twins and singletons: is twinship a risk or an advantage?

2003

We compared twins to their gender-matched singleton classmates in peer-assessed behavioral adjustment. Our samples include 1874 11- to 12-year-old Finnish twins (687 monozygotic, MZ; 610 same-sex dizygotic, SSDZ; 577 opposite-sex dizygotic, OSDZ) and their 23,200 non-twin classmates. Data were collected using a 30-item Multidimensional Peer Nomination Inventory containing three factors and their subscales. We found twin-singleton differences: classmates rated twin girls and boys higher than gender-matched singletons in Adaptive Behaviors (constructive, compliant, and socially active behavior), and those effects were particularly evident among OSDZ twins for assessments of social interaction…

MaleTwinsPoison controlChild Behavior DisordersAnxietyPeer GroupDevelopmental psychology03 medical and health sciences0302 clinical medicineAdaptation PsychologicalmedicineHumans0501 psychology and cognitive sciences10. No inequalityChildGenetics (clinical)FinlandAnalysis of VarianceSocioemotional selectivity theoryAggressionDepression05 social sciencesSocial anxietyObstetrics and GynecologyPeer groupTwin studySocial relationPediatrics Perinatology and Child HealthFemalemedicine.symptomPsychologyTwins Early Development StudySocial Adjustment030217 neurology & neurosurgery050104 developmental & child psychologyPersonalityTwin research : the official journal of the International Society for Twin Studies
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Genetic analysis of reaction time variability: room for improvement?

2013

Background. Increased reaction time variability (RTV) on cognitive tasks requiring a speeded response is characteristic of several psychiatric disorders. In attention deficit hyperactivity disorder (ADHD), the association with RT is strong phenotypically and genetically, yet high RTV is not a stable impairment but shows ADHD-sensitive improvement under certain conditions, such as those with rewards. The state regulation theory proposed that the RTV difference score, which captures change from baseline to a rewarded or fast condition, specifically measures ‘state regulation’. By contrast, the interpretation of RTV baseline (slow, unrewarded) scores is debated. We aimed to investigate directl…

Maleevent rateAdolescentDEFICIT HYPERACTIVITY DISORDERTWINS EARLY DEVELOPMENTMedizinTwinsSocial Sciences610 Medicine & health3202 Applied PsychologyBEHAVIOR PROBLEMS2738 Psychiatry and Mental HealthrewardsReaction TimeTwins Dizygoticddc:61ADHDHumansddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersChildModels GeneticATTENTION-DEFICIT/HYPERACTIVITY DISORDEROriginal ArticlesTwins Monozygotic10058 Department of Child and Adolescent PsychiatryPERFORMANCEInhibition PsychologicalPhenotypereaction time variabilityAttention Deficit Disorder with HyperactivityCONDUCT DISORDERCase-Control StudiesRELIABILITYINTRASUBJECT VARIABILITYFemalegenetic effectsCRITERION VALIDITYPsychological Medicine
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Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial.

2014

Importance The disease process leading to clinical type 1 diabetes often starts during the first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas do not contain intact proteins. Objective To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of diabetes-associated autoantibodies in young children. Design, Setting, and Participants A double-blind randomized clinical trial of 2159 infants with HLA-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to Ja…

Maleinsulin-Secreting CellsautoantibodiesAutoimmunity2700 General MedicineGastroenterologylaw.invention0302 clinical medicineRandomized controlled trialnewbornlawCaseindouble-blind methodCumulative incidence030212 general & internal medicinehumans: Multidisciplinary general & others [D99] [Human health sciences]childHazard ratioGeneral Medicinefollow-up studiesInfant Formulaanimalscaseinstype 1femaleMilkbreast feedinghydrolysisdiabetes mellitusRiskmedicine.medical_specialty: Multidisciplinaire généralités & autres [D99] [Sciences de la santé humaine]β-cell autoimmunity610 Medicine & health030209 endocrinology & metabolismWeaningArticlehydrolyzed infant formula03 medical and health sciencesInternal medicineDiabetes mellitusHydrolyzed infant formula and early β-cell autoimmunitymedicineanimals; autoantibodies; breast feeding; caseins; child; diabetes mellitus; type 1; dietary proteins; double-blind method; female; follow-up studies; humans; hydrolysis; incidence; infant; newborn; insulin-Secreting Cells; Male; Milk; Risk; Weaning; Autoimmunity; Infant FormulaType 1 diabetesbusiness.industrydietary proteinsta1183Infant Newbornmedicine.diseaseta3123infantDiabetes Mellitus Type 1EndocrinologyInfant formula10036 Medical ClinicincidencebusinessBreast feeding
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Early endovascular aneurysm repair after percutaneous coronary interventions

2015

Objective The objective of this study was to report long-term results of early endovascular aortic aneurysm repair after percutaneous coronary intervention (PCI). Methods This was a retrospective analysis of all patients presenting with abdominal aortic aneurysm and coronary artery disease treated during the same hospitalization by endovascular aortic aneurysm repair performed soon after PCI. Primary outcomes were perioperative mortality, perioperative complications, survival after treatment, and freedom from reintervention. Results A total of 20 patients were included, and all completed both procedures. No deaths or abdominal aortic aneurysm ruptures occurred between the PCI and the aortic…

Malemedicine.medical_treatmentCoronary DiseaseComorbidityEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareCoronary artery diseaseAortic aneurysmPostoperative ComplicationsRisk FactorsRetrospective StudieCause of DeathMyocardial infarctionHospital MortalityAged; Aged 80 and over; Aortic Aneurysm Abdominal; Cause of Death; Combined Modality Therapy; Comorbidity; Coronary Disease; Follow-Up Studies; Hospital Mortality; Humans; Italy; Male; Middle Aged; Postoperative Complications; Reoperation; Retrospective Studies; Risk Factors; Survival Rate; Early Medical Intervention; Percutaneous Coronary Intervention; Cardiology and Cardiovascular Medicine; Surgery; Medicine (all)Aged 80 and overMedicine (all)Middle AgedCombined Modality TherapyAbdominal aortic aneurysm2746 SurgerySurvival RateItalycardiovascular systemCardiologyCardiology and Cardiovascular MedicineHumanReoperationmedicine.medical_specialty10216 Institute of Anesthesiology610 Medicine & health2705 Cardiology and Cardiovascular MedicineFollow-Up StudiePercutaneous Coronary InterventionInternal medicineEarly Medical InterventionmedicineHumanscardiovascular diseasesRetrospective StudiesAgedbusiness.industryRisk FactorPercutaneous coronary interventionPerioperativemedicine.disease10020 Clinic for Cardiac SurgerySurgeryConventional PCISurgeryPostoperative ComplicationbusinessFollow-Up StudiesAortic Aneurysm Abdominal
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Time to recurrence is a significant predictor of cancer-specific survival after recurrence in patients with recurrent renal cell carcinoma - Results …

2013

Objectives To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. To analyse differences in clinical and histopathological criteria between patients with early and late recurrence. Patients and Methods Of 13 107 patients with RCC from an international multicentre database, 1712 patients developed recurrence in the follow-up (FU), at a median (interquartile range) of 50.1 (25-106) months. In all, 1402 patients had recurrence at ≤5 years (Group A) and 310 patients beyond this time (Group B). Differences in clinical and histopathological…

Malerenal cell carcinomaTime FactorsTime FactorDatabases FactualPrognosiUrologyprognostic parameterearly recurrencetime to recurrencecancer-specific survivalRetrospective Studielate recurrencenephrectomyHumanscancer survivalCarcinoma Renal Cellrenal cell carcinoma (RCC); time to recurrence; early recurrence; late recurrence; prognostic parameters; cancer-specific survival; nephrectomyAgedRetrospective StudiesKidney NeoplasmMiddle Agedprognostic parametersPrognosisKidney NeoplasmsSurvival Ratecancer survival; early recurrence; late recurrence; nephrectomy; prognostic parameters; renal cell carcinomacancer-specific survival; early recurrence; late recurrence; nephrectomy; prognostic parameters; renal cell carcinoma; time to recurrenceFemaleNeoplasm Recurrence Localrenal cell carcinoma (rcc)cancer-specific survival; early recurrence; late recurrence; nephrectomy; prognostic parameters; renal cell carcinoma (rcc); time to recurrenceHuman
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The Pomar Codex (ca, 1590): plants and animals of the old world and from the Hernandez expedition to America.

1992

Abstract<title> RIASSUNTO </title>Si descrive un codice illustrato (ca. 1590), donato dal re Filippo II a Honorato Pomar, professore di medicina botanica all'Università di Valencia, e ora conservato nella biblioteca della stessa universita. Tale codice contiene 218 acquarelli di piante e animali del Vecchio Continente e provenienti dalla spedizione nelle Americhe di Hernandez (1571-1577). Inoltre, l'articolo si sofferma brevemente sull'interesse di Filippo II per la storia naturale, sulla spedizione di Hernandez e sulla cattedra di botanica medica all'universita di Valencia nel corso del sedicesimo secolo. Infine, si discute dell'identita dell'autore delle illustrazioni e dei te…

Manuscripts as TopicHistory and Philosophy of ScienceSpainmedia_common.quotation_subjectHistory Early Modern 1451-1600History Modern 1601-Medical IllustrationBotanyArtHumanitiesmedia_commonNuncius
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