Search results for " effect"
showing 10 items of 7524 documents
Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
2020
Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …
Beta-decay studies for applied and basic nuclear physics
2020
In this review we will present the results of recent beta-decay studies using the total absorption technique that cover topics of interest for applications, nuclear structure and astrophysics. The decays studied were selected primarily because they have a large impact on the prediction of a) the decay heat in reactors, important for the safety of present and future reactors and b) the reactor electron antineutrino spectrum, of interest for particle/nuclear physics and reactor monitoring. For these studies the total absorption technique was chosen, since it is the only method that allows one to obtain beta decay probabilities free from a systematic error called the Pandemonium effect. The me…
Safety and potential interaction of immunosuppressive drugs for the treatment of inflammatory bowel disease in elderly patients
2021
Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are chronic diseases associated with increased morbidity and reduced quality of life. Age may represent a risk factor for adverse events, due to the multimorbidity and polypharmacy, common in elderly patients. Elderly are often not included in clinical trials evaluating efficacy and safety of study drugs for the treatment of inflammatory bowel diseases. Several drugs, such as aminosalicylates, systemic corticosteroids, immunosuppressant drugs, biological drugs and Janus Kinase inhibitors, are available for the management of inflammatory bowel diseases. With the increasing spectrum of therapeutic options, it is th…
Safety and Tolerance Evaluation of Milk Fat Globule Membrane-Enriched Infant Formulas: A Randomized Controlled Multicenter Non-Inferiority Trial in H…
2014
ObjectiveThis multicenter non-inferiority study evaluated the safety of infant formulas enriched with bovine milk fat globule membrane (MFGM) fractions.MethodsHealthy, full-term infants ( n = 119) age ≤14 days were randomized to standard infant formula (control), standard formula enriched with a lipid-rich MFGM fraction (MFGM-L), or standard formula enriched with a protein-rich MFGM fraction (MFGM-P). Primary outcome was mean weight gain per day from enrollment to age 4 months (non-inferiority margin: –3.0 g/day). Secondary (length, head circumference, tolerability, morbidity, adverse events) and exploratory (phospholipids, metabolic markers, immune markers) outcomes were also evaluated.Res…
Effects of low laser level therapy in rehabilitation of patients with COVID19 pneumonia
2021
Introduction. An unprecedented public health crisis has been triggered worldwide by SARS-CoV-2’s high contagiosity and it’s mortality rates of 1-5%. Although the majority of COVID-19 cases have a good outcome, there is a small percentage that develop severe pneumonia and citokine storm and may be in the need of mechanical ventilation. Methods. Identifying the exact drivers of the excessive inflammation and the biomarkers that can predict a hyperinflammatory response to SARS-CoV-2 would be extremly helpful in finding efficient anti-inflammatory interventions that may stop the progression to acute respiratory distress syndrome (ARDS). Results. In the search for such interventions we have iden…
PLOT LENGTH EFFECTS ON RUNOFF AND SOIL EROSION AT THE SPARACIA EXPERIMENTAL SITE
2018
Explaining scale effects for runoff and erosion improves our understanding of erosion processes. In this investigation, plot length effects on event runoff per unit area, Qe, sediment concentration, Ce, and soil loss per unit area, SLe, were checked at the Sparacia (Italy) site. The most common result, occurring for the 57-62% of the events depending on the considered variable, was the lack of any scale effect. When scale effects were detected, they indicated that longer plots yielded smaller Qe and SLe values and higher Ce values. Rainfall characteristics did not explain the occur-rence of significant scale effects nor they were able to describe changes in the scaling exponent for Ce and S…
Multi-Energy School System for Seasonal Use in the Mediterranean Area
2020
School buildings represent an energy-consuming sector of real estate where different efficiency actions are necessary. The literature shows how the design of a multi-energy system offers numerous advantages, however, there are problems related to the integration of cogeneration units with renewable energy sources due to the low flexibility of the first one and the high degree of uncertainty of the latter. The authors provide an alternative solution through the analysis of a case study consisting of a multiple energy system in three Sicilian schools, focusing on the system&rsquo
Unique Problems Require Unique Solutions—Models and Problems of Linking School Effectiveness and School Improvement
2022
The article aims to outline the proposals for linking school effectiveness research and school improvement that are currently relevant in international discussion and to ask how they deal with the ‘technology deficit’ at the level of model improvement. We will first show the difference between school improvement and school effectiveness. Then, we outline areas showing basic problems associated with linking school effectiveness and school improvement. After that, we present a summary of two relevant models for linking school effectiveness research and school improvement—Comprehensive Framework of Effective School Improvement and Dynamic Model of Educational Effectiveness&md…
Are Public Subsidies to Encourage Young Farmers Effective? Case Study of a First-Time Farm Set Up by a Young Female Farmer in the Valencian Region of…
2021
Generational renewal and the incorporation of women into the rural world are fundamental for the sustainability and modernisation of the agricultural sector. Hence the special government protection granted to the sector, which appears in both European legislation on rural issues and in the global strategy of the 2030 Agenda and the Sustainable Rural Development Goals involving a commitment to measures aimed at helping young farmers to set up agricultural holdings and especially at encouraging women to engage in farm management. In the case of Spain, this is nothing new, given that Law 35/2011 on the Shared Ownership of Agricultural Holdings became a veritable revolution in terms of gender i…
Girls4STEM: Gender Diversity in STEM for a Sustainable Future
2020
Science, Technology, Engineering, and Mathematics (STEM) are key disciplines towards tackling the challenges related to the Sustainable Development Goals. However, evidence shows that women are enrolling in these disciplines in a smaller percentage than men, especially in Engineering related fields. As stated by the United Nations Women section, increasing the number of women studying and working in STEM fields is fundamental towards achieving better solutions to the global challenges, since the potential for innovation is larger. In this paper, we present the Girls4STEM project, which started in 2019 at the Escola Tè