Search results for " elements"
showing 10 items of 732 documents
Knowledge Creation - A Perspective on the Development of Design Principles
2020
In this paper we reflect on and conceptualize on the development of design principles in a design process. We use the concept of ba to describe how design principles can be created when involving users, domain experts, designers and researchers in the design process. The study applies action design research (ADR) to design and develop a self-reflective career support tool for persons with intellectual disabilities (ID). We have applied processes of knowledge creation and their corresponding ba, the originating ba, the interacting ba, the systemizing ba and the exercising ba to conceptualize the development of design principles. Preliminary findings imply that a structured process of knowled…
Virulence-Associated Mobile Elements in Bacilli and Clostridia
2014
This chapter focuses on (i) species that induce human diseases, (ii) species that are able to produce toxins, and (iii) the association of appropriate virulence factors with possible mobile elements. With reference to bacilli, the chapter discusses mainly Bacillus anthracis and B. cereus. A section on clostridia focuses on Clostridium perfringens, neurotoxin-producing clostridia, and species capable of producing large clostridial cytotoxins (LCTs). The chapter talks about the contribution of the genetic mobility of virulence genes to the evolution of pathogenic bacilli and clostridia. B. anthracis strains produce a tripartite protein toxin, comprising PA (protective antigen), EF (edema fact…
The impact of the Little ice age on coccolithophores in the central Mediterranea Sea
2010
The Little Ice Age (LIA) is the last episode of a series of Holocene climatic anomalies. There is still little knowledge on the response of the marine environment to the pronounced cooling of the LIA and to the transition towards the 20th century global warming. Here we present decadal-scale coccolithophore data from four short cores recovered from the central Mediterranean Sea (northern Sicily Channel and Tyrrhenian Sea), which on the basis of <sup>210</sup>Pb activity span the last 200–350 years. The lowermost part of the record of one of the cores from the Sicily Channel, Station 407, which extends down to 1650 AD, is characterized by drastic changes in productivity. Specific…
Goalkeeper: A Zero-Sum Exergame for Motivating Physical Activity
2021
Incentives and peer competition have so far been employed independently for increasing physical activity. In this paper, we introduce Goalkeeper, a mobile application that utilizes deposit contracts for motivating physical activity in group settings. Goalkeeper enables one to set up a physical exercise challenge with a group of peers that deposit a fixed amount of money for participating. If a peer fails to complete the challenge, Goalkeeper redistributes their deposit to those who managed to complete it (i.e., zero-sum game). We evaluated the potential of Goalkeeper in increasing physical activity with a total of 50 participants over the course of 2 months. Our findings suggest that deposi…
<title>Collisional and thermal ionization of sodium Rydberg atoms in single and crossed atomic beams</title>
2006
The results of the experimental and theoretical study on associative ionization of laser excited Na Rydberg atoms in collisions with ground-state atoms and on thermal ionization by blackbody radiation in single and crossed effusive atomic beams are reported and discussed.
Mining minerals and critical raw materials from bittern: Understanding metal ions fate in saltwork ponds
2022
Seawater represents a potential resource for raw materials extraction. Although NaCl is the most representative mineral extracted other valuable compounds such as Mg, Li, Sr, Rb and B and elements at trace level (Cs, Co, In, Sc, Ga and Ge) are also contained in this “liquid mine”. Most of them are considered as Critical Raw Materials by the European Union. Solar saltworks, providing concentration factors of up-to 20 to 40, offer a perfect platform for the development of minerals and metal recovery schemes taking benefit of the concentration and purification achieved along the evaporation saltwork ponds. However, the geochemistry of these elements in this environment has not been yet thoroug…
Sustainable recovery of critical elements from seawater saltworks bitterns by integration of high selective sorbents and reactive precipitation and c…
2023
The availability of raw mineral resources containing elements included in the Critical Raw Materials (CRMs) list is a growing concern for the European Union. Sea mining has been identified as a promising secondary source. In particular, brines obtained in solar saltworks (bitterns) contain relevant amounts of valuable CRMs such as Mg(II), B(III), other alkaline/alkaline earth metals (Rb(I), Cs(I), Sr(II)) and transition/post-transition elements (Co(II), Ga(III), Ge(IV)). However, the low concentration of some of these elements (µg/L) requires an effort to develop recovery routes that are sustainable and economically feasible where the required chemicals and energy are produced on-site from …
Poplar rotation coppice at a trace element-contaminated phytomanagement site: A 10-year study revealing biomass production, element export and impact…
2019
Abstract Growing lignocellulosic crops on marginal lands could compose a substantial proportion of future energy resources. The potential of poplar was explored, by devising a field trial of two hectares in 2007 in a metal-contaminated site to quantify the genotypic variation in the growth traits of 14 poplar genotypes grown in short-rotation coppice and to assess element transfer and export by individual genotypes. Our data led us to conclusions about the genotypic variations in poplar growth on a moderately contaminated site, with the Vesten genotype being the most productive. This genotype also accumulated the least amounts of trace elements, whereas the Trichobel genotype accumulated up…
Regulation of ribonucleotide reductase in response to iron deficiency
2011
Ribonucleotide reductase (RNR) is an essential enzyme required for DNA synthesis and repair. Although iron is necessary for class Ia RNR activity, little is known about the mechanisms that control RNR in response to iron deficiency. In this work, we demonstrate that yeast cells control RNR function during iron deficiency by redistributing the Rnr2–Rnr4 small subunit from the nucleus to the cytoplasm. Our data support a Mec1/Rad53-independent mechanism in which the iron-regulated Cth1/Cth2 mRNA-binding proteins specifically interact with the WTM1 mRNA in response to iron scarcity, and promote its degradation. The resulting decrease in the nuclear-anchoring Wtm1 protein levels leads to the re…
ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1).
2000
The Myc promoter-binding protein-1 (MBP-1) is a 37-38 kDa protein that binds to the c-myc P2 promoter and negatively regulates transcription of the protooncogene. MBP-1 cDNA shares 97% similarity with the cDNA encoding the glycolytic enzyme alpha-enolase and both genes have been mapped to the same region of human chromosome 1, suggesting the hypothesis that the two proteins might be encoded by the same gene. We show here data indicating that a 37 kDa protein is alternatively translated from the full-length alpha-enolase mRNA. This shorter form of alpha-enolase is able to bind the MBP-1 consensus sequence and to downregulate expression of a luciferase reporter gene under the control of the c…