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showing 10 items of 3049 documents

Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH sur…

2017

Background Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays. Methods A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to …

0301 basic medicinecytomegalovirus; solid organ transplantation; survey.cytomegalovirus ; solid organ transplantation ; surveyCross-sectional studyCytomegalovirusTransplantsPractice Patterns030230 surgeryOrgan transplantationlaw.invention0302 clinical medicinePostoperative Complicationslaw03.02. Klinikai orvostanViralPractice Patterns Physicians'solid organ transplantationPolymerase chain reactionViral LoadEuropeInfectious DiseasesCytomegalovirus InfectionsPractice Guidelines as Topiccytomegalovirus; solid organ transplantation; survey; Antibiotic Prophylaxis; Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus; Cytomegalovirus Infections; DNA Viral; Europe; Guideline Adherence; Health Care Surveys; Humans; Immunocompromised Host; Immunosuppression; Organ Transplantation; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns Physicians'; Real-Time Polymerase Chain Reaction; Transplant Recipients; Transplants; Viral LoadGuideline Adherencecytomegalovirus; solid organ transplantation; survey; Antibiotic Prophylaxis; Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus; Cytomegalovirus Infections; DNA Viral; Europe; Guideline Adherence; Health Care Surveys; Humans; Immunocompromised Host; Immunosuppression; Organ Transplantation; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns Physicians'; Real-Time Polymerase Chain Reaction; Transplant Recipients; Transplants; Viral Load; Transplantation; Infectious Diseasesmedicine.medical_specialty030106 microbiologyCongenital cytomegalovirus infectionReal-Time Polymerase Chain ReactionAntiviral Agents03 medical and health sciencesImmunocompromised HostmedicineHumanssurveyIntensive care medicineImmunosuppression TherapyTransplantationPhysicians'business.industryDNAOrgan TransplantationAntibiotic Prophylaxismedicine.diseaseMolecular diagnosticsTransplant RecipientsCytomegalovirus infectionTransplantationcytomegalovirus; solid organ transplantation; survey; Transplantation; Infectious DiseasesCross-Sectional StudiesCytomegalovirus; Solid organ transplantation; Survey; Transplantation; Infectious DiseasesHealth Care SurveysDNA ViralImmunologySolid organ transplantationbusinessImmunosuppression
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Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive err…

2020

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal curvature and eye elongation (i.e. axial length) to maintain eyes in emmetropia (i.e. HDAC11/FBLN2 rs2630445, RBP3 rs11204213); others exhibited association with myopia with little pleiotropic effects …

0301 basic medicinegenetic structuresMedicine (miscellaneous)EmmetropiaGenome-wide association studyVARIANTSGenome-wide association studiesSensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]Cornea0302 clinical medicineRisk FactorsCorneaDatabases GeneticMULTIPLEMyopiaGene Regulatory NetworksEXPRESSION PATTERNS10. No inequalitylcsh:QH301-705.5POPULATIONGeneticseducation.field_of_studymedicine.diagnostic_testHERITABILITYCorneal DiseasesAsian Continental Ancestry Group ; Axial Length Eye ; Cornea ; Corneal Topography ; Databases Genetic ; European Continental Ancestry Group ; Gene Regulatory Networks ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Myopia ; Phenotype ; Polymorphism Single Nucleotide ; Refractometry ; Risk Assessment ; Risk FactorsCorneal topographyEYE SIZE3. Good healthAxial Length EyePhenotypemedicine.anatomical_structureGeneral Agricultural and Biological SciencesExtracellular matrix organizationKeratoconusCorneal diseasesPopulationBiologyPolymorphism Single NucleotideRisk AssessmentArticleWhite PeopleGeneral Biochemistry Genetics and Molecular BiologyOCULAR COMPONENT DIMENSIONS03 medical and health sciencesSPHERICAL EQUIVALENTAsian PeoplemedicineHumansGenetic Predisposition to DiseaseKERATOCONUS3125 Otorhinolaryngology ophthalmologyeducationCorneal Topographymedicine.diseaseCOLLAGENeye diseasesRefractometry030104 developmental biologylcsh:Biology (General)Genetic LociRE3111 Biomedicinesense organs030217 neurology & neurosurgeryGenome-Wide Association StudyCommunications Biology
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Maristem stem cells of marine/aquatic invertebrates: from basic research to innovative applications

2018

The “stem cells” discipline represents one of the most dynamic areas in biomedicine. While adult marine/aquatic invertebrate stem cell (MISC) biology is of prime research and medical interest, studies on stem cells from organisms outside the classical vertebrate (e.g., human, mouse, and zebrafish) and invertebrate (e.g., Drosophila, Caenorhabditis) models have not been pursued vigorously. Marine/aquatic invertebrates constitute the largest biodiversity and the widest phylogenetic radiation on Earth, from morphologically simple organisms (e.g., sponges, cnidarians), to the more complex mollusks, crustaceans, echinoderms, and protochordates. These organisms contain a kaleidoscope of MISC-type…

0301 basic medicinemarine/aquatic invertebratesQH301 Biologymarine/aquatic invertebrateBioactive moleculesT-NDASGeography Planning and Developmentlcsh:TJ807-830BiodiversitySettore BIO/05 - ZoologiaStem cellsblue biotechnology0302 clinical medicineBioactive moleculeBasic researchaging ; bioactive molecules ; blue biotechnology ; cancer ; cell culture ; COST Action ; Europe ; marine/aquatic invertebrates ; regeneration ; stem cellsGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)lcsh:Environmental sciencesCancerlcsh:GE1-350quinonessea-urchin eggsStem cellGeographyPolicy and LawEcologylcsh:Environmental effects of industries and plantsManagementEuropeMarine/aquatic invertebrateStem cellCèl·lules mareEuropean communityMonitoringaging; bioactive molecules; blue biotechnology; cancer; cell culture; COST Action; Europe; marine/aquatic invertebrates; regeneration; stem cellslcsh:Renewable energy sourcesCOST ActionAging; Bioactive molecules; Blue biotechnology; Cancer; Cell culture; COST Action; Europe; Marine/aquatic invertebrates; Regeneration; Stem cells; Geography Planning and Development; Renewable Energy Sustainability and the Environment; Management Monitoring Policy and LawManagement Monitoring Policy and LawBiologyQH30103 medical and health sciencesSDG 3 - Good Health and Well-beingNear neighborunitsstem cellsbioactive moleculesevolutioncancerSDG 14 - Life Below WaterRenewable Energy14. Life underwaterSH Aquaculture. Fisheries. AnglingSHRegeneration (ecology)BiologyBiomedicineInvertebratePlanning and Developmentcell cultureScience & TechnologySustainability and the EnvironmentRenewable Energy Sustainability and the Environmentbusiness.industryMarine invertebratesagingInvertebrats marinsbioactive moleculecell_developmental_biology030104 developmental biologylcsh:TD194-19513. Climate actionregenerationproteinbusiness030217 neurology & neurosurgery
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A Pilot Study on Markers of Genetic Predisposition in Tuberculous Pneumonia Patients In Latgale

2019

Abstract Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. …

0301 basic medicinemedicine.medical_specialtyTuberculosislatgaleScienceHuman leukocyte antigenlaw.invention03 medical and health sciences0302 clinical medicinelawInternal medicinemedicineGenetic predispositionAllelePolymerase chain reactionMultidisciplinarybusiness.industryIncidence (epidemiology)Qhla class iimedicine.diseaseEastern europeanPneumonia030104 developmental biologytuberculosisbusiness030215 immunologyProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences
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Ancient bacterial genomes reveal a formerly unknown diversity ofTreponema pallidumstrains in early modern Europe

2020

SummarySexually transmitted (venereal) syphilis marked European history with a devastating epidemic at the end of the 15thcentury, and is currently re-emerging globally. Together with non-venereal treponemal diseases, like bejel and yaws, found in subtropical and tropical regions, it poses a prevailing health threat worldwide. The origins and spread of treponemal diseases remain unresolved, including syphilis’ potential introduction into Europe from the Americas. Here, we present the first genetic data from archaeological human remains reflecting a previously unknown diversity ofTreponema pallidumin historical Europe. Our study demonstrates that a variety of strains related to both venereal…

0303 health sciencesTreponemaLineage (genetic)biologymedia_common.quotation_subject030231 tropical medicineGenetic dataBacterial genome sizemedicine.diseasebiology.organism_classification3. Good health03 medical and health sciences0302 clinical medicineSister groupEvolutionary biologymedicineSyphilisEarly modern Europe030304 developmental biologyDiversity (politics)media_common
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White Book on Physical and Rehabilitation Medicine in Europe. Introductions, Executive Summary, and Methodology

2018

The White Book (WB) of Physical and Rehabilitation Medicine (PRM) in Europe is produced by the 4 European PRM Bodies (European Academy of Rehabilitation Medicine - EARM, European Society of PRM - ESPRM, European Union of Medical Specialists - PRM Section, European College of PRM-ECPRM served by the European Union of Medical Specialists-PRM Board) and constitutes the reference book for PRM physicians in Europe. It has now reached its third edition; the first was published in 1989 and the second in 2006/2007. The WB has multiple purposes, including providing a unifying framework for European countries, to inform decision-makers on European and national level, to offer educational material for…

030506 rehabilitationmedicine.medical_specialtymedicine.medical_treatmentSpecialtyPhysical Therapy Sports Therapy and RehabilitationWorld healthConvention03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationHumansMedicinemedia_common.cataloged_instanceDisabled PersonsBooks* Disabled Persons/rehabilitation* Europe Humans Physical and Rehabilitation Medicine*FunctioningEuropean unionCompetence (human resources)media_commonDisabilityExecutive summaryRehabilitationbusiness.industryBooksRehabilitationPhysical and Rehabilitation MedicineEuropeAction plan0305 other medical sciencebusiness030217 neurology & neurosurgeryEuropean Journal of Physical and Rehabilitation Medicine
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Loss of habitats, naturalness and species diversity in Eurasian forest landscapes

2010

Abstract Man has exploited land and forests in Western and Central Europe longer and more intensively than in Northern Europe and further east in Eurasia. We estimated forest naturalness and modelled expected biodiversity loss in seven different landscapes (2500 km2 each) in the Netherlands, Sweden, Finland, Poland, St. Petersburg (Western European Russia), Perm (Eastern European Russia), and Irkutsk (Central Siberia) across the distribution of Pinus sylvestris L. in Eurasia. Field inventories showed that the mean living tree volumes were relatively similar in the studied sites, but the volumes of dead wood differed greatly. In Irkutsk and Perm the volume of dead trees per ha was about 5–10…

040101 forestry0106 biological sciencesExtinctionEcologybusiness.industryEcologyBiodiversityGeneral Decision SciencesDistribution (economics)Species diversityDead woodForestry04 agricultural and veterinary sciences15. Life on land010603 evolutionary biology01 natural sciencesEastern europeanGeographyHabitat destructionHabitat0401 agriculture forestry and fisheriesbusinessEcology Evolution Behavior and SystematicsEcological Indicators
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Becoming more EUropean or European after ERASMUS?

2015

Lijphart was the first to emphasize the necessity to study the impact of student mobility upon European integration, but mobility programmes have only been studied in the last decade. The European Commission points to the ERASMUS programme as a successful example of construction of European identity; however, this assumption hasn’t yet been empirically proved on an European scale. This paper has been devoted to research of the impact of the ERASMUS programme on fostering European identity in Europe. In academic literature at least two different understandings of the European identity can be distinguished: political and cultural European identity. The quantitative survey (in which 12’173 res…

05 social sciences0507 social and economic geographyPharmaceutical ScienceERASMUSKEuropean studies0506 political scienceJComplementary and alternative medicinePolitical scienceEuropean integration050602 political science & public administrationEconomic historyPharmacology (medical)political vs. cultural European identity050703 geographyErasmus+LawPolitical scienceEuropean identityPoliteja
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Una segregazione paradossale e multi-scalare: il caso del quartiere ZEN di Palermo

2016

L’articolo affronta la questione della segregazione nel quartiere ZEN di Palermo (Sicilia). L’impianto teorico dialoga con la letteratura anglosassone, ma ne prende le distanze nel tentativo di individuare alcune specificità locali del caso. L’obiettivo è duplice: intanto indentificare alcuni “movimenti geostorici” che hanno caratterizzato il quartiere, collegando a ciascuno di questi una fase del processo segregativo; inoltre, rappresentare la segregazione del quartiere in forma cartografica, mediante l’uso di alcuni ideogrammi e mappe mentali. This article deals with the issue of segregation in the ZEN district of Palermo, Sicily. The theoretical framework is built around Anglo-Saxon refe…

05 social sciencesGeography Planning and Development0211 other engineering and technologies0507 social and economic geography021107 urban & regional planning02 engineering and technologySegregazioneEuropa mediterraneaUrban StudiesSegregazione Europa mediterranea ZEN mappe mentali ideogrammiSegregation Mediterranean Europe ZEN mental maps ideogramsEarth and Planetary Sciences (miscellaneous)ideogrammimappe mentaliSettore M-GGR/01 - Geografia050703 geographyZENMéditerranée
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Democratic Principles and the Economic Branch of the European Monetary Union

2017

L'articolo si propone di indagare sul valore che i vari principi democratici enunciati nel TUE hanno nello specifico settore dell'UEM, in particolare nel pilastro della politica economica, dopo l'entrata in vigore delle riforme contenute nel Six pack e nel successivo Two Pack. Il lavoro intende in particolare rispondere a tre domande: A) le regole contenute nel six pack e nel two pack in tema di controllo democratico sono espressione di un preciso modello di controllo democratico sulle scelte di politica economica nell'ambito dell'UEM? B) E' un simile modello compatibile con i principi democratici del TUE? C) I principi democratici non rappresentativi possono compensare il minor peso che vi…

050502 lawPublic economicsSettore IUS/14 - Diritto Dell'Unione Europeamedia_common.quotation_subject05 social sciencesDemocracy0506 political scienceFiscal policyRepresentative democracyPolitical scienceDemocracy - European and Monetary Union - Six Pack - Two Pack - democratic principles050602 political science & public administrationMember stateEconomic and monetary unionDemocrazia - Unione economica e monetaria - Six Pack - Two Pack - Principi democraticimedia_common.cataloged_instanceEuropean unionTreatyTreaty of Lisbon0505 lawLaw and economicsmedia_common
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