6533b7d8fe1ef96bd126a55e
RESEARCH PRODUCT
Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey
David NavarroRafael San-juanOriol ManuelEstela Gimã©nezMario Fernã¡ndez-ruizHans H. HirschPaolo Antonio GrossiJosã© Marãa AguadoMaja AbramDaniel AbramowiczJosã©-marãa ÃLamoSehnaz AlpAmado Andres-belmontePouleur Anne-catherineBarbara AntonelliMiha ArnolAyse Hande ArslanArgiris AsderakisFausto BaldantiIsabel Beneyto-castelloKabamba Mukadi BenoitMarino BlanesKatia BoggianRenzo BonofiglioMarina Bubonja-sonjeSophie CaillardJorge CalvoAlessandro CaponeGianni CappelliMario CarmelliniFernando CasafontM. Beatriz Castro-hernandezPilar CatalanBressollette-bodin CelineBerger ChristophElisa CorderoCristina CostaJulien CoussementValentin Cuervas-monsMiruna DavidJuliã¡n De La Torre CisnerosJuan F. DelgadoLuca Dello StrologoOlivier DetryLaura DexterHoffmann DieterAnna Meis-hã¼bingerEric EpaillyBo-goran EriczonBritt-marie ErikssonImre FehervariSusan FitzgeraldLola FolgueiraJesus FortunErica FranceschiniProot FrancoisVanda FrimanSilvius FrimmelChristian GarzoniAdelina GimenoEffrossyni Gkrania-klotsasMark GreerPaul GriffithsJosep M. Grinyã³Giovanni GuaraldiGirish GupteAbdul HammadIan HartIlkka Helanterã¤Rachel HellemansDomingo Hernã¡ndezJose Ignacio HerreroChristian HiesseMaria Hoppe-lotichiusEwa HryniewieckaPeter JakschLerut JanBrion Jean PaulSoren Jensen-fangelSteinmann JoergVanhaecke JohanIngolfur JohannessenInger JohanssonNassim KamarFiliz KizilatesChristiane KnoopBelec LaurentAugusto LauroIrmeli LautenschlagerRicardo LauzuricaU. G. LiebertPaolalilla Dela MonicaLaura LladoRafael Lopez-andujarFilippo LucianiMassimo MaccheriniJohan MaertensUmberto MaggioreAlejandro ManriqueMaria Angeles MarcosIvana MarekovicNuno MarquesNitschke MartinNeau MartineAna Martinez-sapiã±aM. Luisa Mateos LindemannAuxiliadora MazuecosEsperanza MerinoFrancesc MoresoNicolas MuellerDavid MuirAlessandra MularoniPatricia Muã±ozAgustãn Muã±oz-sanzSilvio NadalinNicolini Laura AmbraMario NosottiJoanne O. GormanHusam OsmanElizaveta PadalkoBegoã±a Palop-borrã¡sNull JavirparmerSonia PascualMarãa Josã© Pena Lã³pezJosã© Luis Pã©rez-sã¡enzMauro PistelloM. Francisca PorteroElisabeth PuchhammerSara RaccaJanette Rahamat-langendoenAntonio RamosEsther Ramos BoludaMohammad RazaEnrico RegaliaGabriel ReinaTomas ReischigStefan ReuterM. Luisa Rodrãguez-ferreroEmmanuel RoilidesSerena RollaHalvor RollagLionel RostaingFrancesco Paolo RussoNãºria Sabã©Faouzi SalibaAna Sã¡nchez-fructuosoGiorgio ScottonNuria SerraDino SgarabottoJelena StojanovicMeltem TasbakanMauricio TelentiGabriella TerhesStefan ThorbanNijaz TihicGiovanna TraviPatrizia TulissiChristian Van DeldenCoretta Van LeerInge Van LooMarãa Arã¡nzazu Varona-bosqueMassimiliano VerouxAna Vila-santandreuSheila WaughLada ZibarStefan Zschiedrsubject
0301 basic medicinecytomegalovirus; solid organ transplantation; survey.cytomegalovirus ; solid organ transplantation ; surveyCross-sectional studyCytomegalovirusTransplantsPractice Patterns030230 surgeryOrgan transplantationlaw.invention0302 clinical medicinePostoperative Complicationslaw03.02. Klinikai orvostanViralPractice Patterns Physicians'solid organ transplantationPolymerase chain reactionViral LoadEuropeInfectious DiseasesCytomegalovirus InfectionsPractice Guidelines as Topiccytomegalovirus; solid organ transplantation; survey; Antibiotic Prophylaxis; Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus; Cytomegalovirus Infections; DNA Viral; Europe; Guideline Adherence; Health Care Surveys; Humans; Immunocompromised Host; Immunosuppression; Organ Transplantation; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns Physicians'; Real-Time Polymerase Chain Reaction; Transplant Recipients; Transplants; Viral LoadGuideline Adherencecytomegalovirus; solid organ transplantation; survey; Antibiotic Prophylaxis; Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus; Cytomegalovirus Infections; DNA Viral; Europe; Guideline Adherence; Health Care Surveys; Humans; Immunocompromised Host; Immunosuppression; Organ Transplantation; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns Physicians'; Real-Time Polymerase Chain Reaction; Transplant Recipients; Transplants; Viral Load; Transplantation; Infectious Diseasesmedicine.medical_specialty030106 microbiologyCongenital cytomegalovirus infectionReal-Time Polymerase Chain ReactionAntiviral Agents03 medical and health sciencesImmunocompromised HostmedicineHumanssurveyIntensive care medicineImmunosuppression TherapyTransplantationPhysicians'business.industryDNAOrgan TransplantationAntibiotic Prophylaxismedicine.diseaseMolecular diagnosticsTransplant RecipientsCytomegalovirus infectionTransplantationcytomegalovirus; solid organ transplantation; survey; Transplantation; Infectious DiseasesCross-Sectional StudiesCytomegalovirus; Solid organ transplantation; Survey; Transplantation; Infectious DiseasesHealth Care SurveysDNA ViralImmunologySolid organ transplantationbusinessImmunosuppressiondescription
Background Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays. Methods A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to an internet service provider (h t t p s://es.surveymonkey. com/) was sent to transplant physicians, transplant infectious diseases specialists, and clinical virologists working at 340 European transplant centers. Results Of the 1181 specialists surveyed, a total of 173 responded (14.8%): 73 transplant physicians, 57 transplant infectious diseases specialists, and 43 virologists from 173 institutions located at 23 different countries. The majority of centers used QNAT assays for active CMV infection monitoring. Most centers preferred commercially-available real-time polymerase chain reaction (RT-PCR) assays over laboratory-developed procedures for quantifying CMV DNA load in whole blood or plasma. Use of a wide variety of DNA extraction platforms and RT-PCR assays was reported. All programs used antiviral prophylaxis, preemptive therapy, or both, according to current guidelines. However, the centers used different criteria for starting preemptive antiviral treatment, for monitoring systemic CMV DNA load, and for requesting genotypic assays to detect emerging CMV-resistant variants. Conclusions Significant variation in CMV infection management in SOT recipients still remains across European centers in the era of molecular testing. International multicenter studies are required to achieve commutability of CMV testing and antiviral management procedures. This article is protected by copyright. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |