0000000000320914

AUTHOR

David Muir

showing 3 related works from this author

Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH sur…

2017

Background Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays. Methods A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to …

0301 basic medicinecytomegalovirus; solid organ transplantation; survey.cytomegalovirus ; solid organ transplantation ; surveyCross-sectional studyCytomegalovirusTransplantsPractice Patterns030230 surgeryOrgan transplantationlaw.invention0302 clinical medicinePostoperative Complicationslaw03.02. Klinikai orvostanViralPractice Patterns Physicians'solid organ transplantationPolymerase chain reactionViral LoadEuropeInfectious DiseasesCytomegalovirus InfectionsPractice Guidelines as Topiccytomegalovirus; solid organ transplantation; survey; Antibiotic Prophylaxis; Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus; Cytomegalovirus Infections; DNA Viral; Europe; Guideline Adherence; Health Care Surveys; Humans; Immunocompromised Host; Immunosuppression; Organ Transplantation; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns Physicians'; Real-Time Polymerase Chain Reaction; Transplant Recipients; Transplants; Viral LoadGuideline Adherencecytomegalovirus; solid organ transplantation; survey; Antibiotic Prophylaxis; Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus; Cytomegalovirus Infections; DNA Viral; Europe; Guideline Adherence; Health Care Surveys; Humans; Immunocompromised Host; Immunosuppression; Organ Transplantation; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns Physicians'; Real-Time Polymerase Chain Reaction; Transplant Recipients; Transplants; Viral Load; Transplantation; Infectious Diseasesmedicine.medical_specialty030106 microbiologyCongenital cytomegalovirus infectionReal-Time Polymerase Chain ReactionAntiviral Agents03 medical and health sciencesImmunocompromised HostmedicineHumanssurveyIntensive care medicineImmunosuppression TherapyTransplantationPhysicians'business.industryDNAOrgan TransplantationAntibiotic Prophylaxismedicine.diseaseMolecular diagnosticsTransplant RecipientsCytomegalovirus infectionTransplantationcytomegalovirus; solid organ transplantation; survey; Transplantation; Infectious DiseasesCross-Sectional StudiesCytomegalovirus; Solid organ transplantation; Survey; Transplantation; Infectious DiseasesHealth Care SurveysDNA ViralImmunologySolid organ transplantationbusinessImmunosuppression
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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

2010

Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epst…

Interferon Regulatory Factor-7Quantitative Trait LociGenome-wide association studyLocus (genetics)Single-nucleotide polymorphismBiologyQuantitative trait locusPolymorphism Single NucleotideArticleReceptors G-Protein-Coupled03 medical and health sciences0302 clinical medicineAnimalsHumansGene Regulatory NetworksGenetic Predisposition to DiseaseGene030304 developmental biologyGeneticsInflammation0303 health sciencesMultidisciplinaryBase SequenceChromosomes Human Pair 13MacrophagesChromosomes MammalianImmunity Innate3. Good healthRatsDiabetes Mellitus Type 1Genetic LociOrgan SpecificityVirusesIRF7Trans-acting030217 neurology & neurosurgeryInterferon regulatory factorsGenome-Wide Association Study
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Bootstrap Technique to Study Correlation Between Neutron Skin Thickness and the Slope of Symmetry Energy in Atomic Nuclei

2017

We present a new statistical tool based on random sampling to assess the confidence interval of Pearson's and Spearman's correlation coefficients. These estimators are then used to quantify the statistical correlations among the neutron skin thickness of atomic nuclei and the slope of the symmetry energy in the infinite nuclear medium.

Nuclear TheoryNuclear TheoryFOS: Physical sciencesGeneral Physics and Astronomy01 natural sciencesSkin thickness114 Physical sciencesNuclear Theory (nucl-th)Correlationnuclear physics0103 physical sciencesMEAN-FIELD DESCRIPTIONNeutron010306 general physicsNuclear ExperimentPhysicsta114010308 nuclear & particles physicsEstimator16. Peace & justiceConfidence intervalSymmetry (physics)Computational physicsAtomic nucleusneutron skinydinfysiikkaEnergy (signal processing)
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