Search results for " evaluation."
showing 10 items of 1351 documents
The effects of an education-leave program on educational attainment and labor-market outcomes
2021
Abstract I study the effect of an education leave subsidy for the employed on labor-market outcomes and educational attainment using Finnish administrative linked employer-employee panel data and matching methods. The adult education allowance is available to employees with at least eight years of work experience and allows them to take a leave for 2–18 months to participate in an education program while being compensated for a substantial part of their forgone earnings. I find large positive treatment effects on educational attainment and changing occupation. The treatment effects on earnings and employment are negative during the lock-in period and close to zero afterward. Treatment effec…
Developing teachers' professional expertise through collaboration in an innovative ICT‐based learning environment
2004
Recent research emphasizes the context‐specific nature of professional knowledge and expertise, implying that developing novel practices in authentic environments is a prerequisite for teachers' professional development. The aim of this study was to find out how teachers develop their practical knowledge and expertise through shared planning and to evaluate an innovative learning project carried out in an ICT‐based environment. Two secondary school teachers of history participated in this study. The data were gathered using a multi‐methodological approach (video recordings, interviews and questionnaires). The results are described in terms of the teachers' shared experiences and their incre…
Doctoral education reform in Finland : institutionalized and individualized doctoral studies within European framework
2017
In Europe, doctoral education systems have been systematically reformed. These reforms are aimed at improving the quality of research and the competitiveness of European countries. In Finland, the reform project of doctoral education started vigorously in the mid-1990s which has contributed significantly to the emergence of more structured doctoral training. The starting point for this article was a recent national follow-up evaluation of doctoral education in Finland. The results are based on qualitative analysis of a survey and interview data collected in the evaluation. The results showed that Finnish universities are launching the university-wide graduate school model. Each university i…
Kombiniertes Simulationstraining: Ein neues Kurskonzept trainiert und verbessert das Krisenmanagement der gastroenterologischen Endoskopie
2005
Introduction Crisis management as well as realistic emergency situations can be trained in the new developed simulation workshop "Gastrointestinal Endoscopy and Crisis Resource Management" by combining a full-scale simulator and the Erlanger Endoscopy Trainer. The aim of the current study was to evaluate the efficiency of the newly developed simulation workshop. Methods Endoscopists with more than 12 months experience can train their endoscopic skills and crisis resource management with the help of different simulators. In addition, two different scenarios (GI bleeding with significant blood loss and sedation overdoses) embedded in a realistic surrounding (emergency room) have to be managed…
Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, in human liver cancer cells are mediated through a reac…
2009
Activation of the nuclear transcription factor-kappa B (NF-kappa B) has been implicated in liver tumorigenesis. We evaluated the effects of a novel NF-kappa B inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), in two human liver cancer cell lines HA22T/VGH and HuH-6. DHMEQ treatment dose dependently decreased the DNA-binding capacity of the NF-kappa B p65 subunit, inhibited cell growth and proliferation, and increased apoptosis as shown by caspase activation, release of cytochrome c, poly(ADP-ribose) polymerase cleavage, and down-regulation of survivin. DHMEQ also induced a dose-dependent activation of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling, …
Early stage diagnosis of programmed cell death (apoptosis) using electroanalysis: Nanomaterial and methods overview
2017
Timely monitoring of apoptosis can effectively assist early diagnosis of related diseases and continuous evaluation of the efficacy of drugs. Therefore, developing advanced methods for apoptosis evaluation has attracted more and more attention. In addition, the increased demand for understanding the early stages of apoptosis is pushing the envelope for solutions in early instance real-time monitoring of death kinetics. In this review, various types of electro-analytical methods for detection of apoptosis were discussed. The emphasis is placed in diagnosis of apoptosis based on cyto-, immune-, geno-, apta-, and peptide based biosensing strategies. In the first part of review, various electro…
Getting Docking into Shape Using Negative Image-Based Rescoring
2019
The failure of default scoring functions to ensure virtual screening enrichment is a persistent problem for the molecular docking algorithms used in the structure-based drug discovery. To remedy this problem, elaborate rescoring and post-processing schemes have been developed with a varying degree of success, specificity, and cost. The negative imagebased rescoring (R-NiB) has been shown to improve the flexible docking performance markedly with a variety of drug targets.The yield improvement is achieved by comparing the alternative docking poses against the negative image of the target protein’s ligand-binding cavity. In other words, the shape and electrostatics of the binding pocket is dir…
Targeting SARS-CoV-2 RBD Interface: a Supervised Computational Data-Driven Approach to Identify Potential Modulators
2020
Coronavirus disease 2019 (COVID-19) has spread out as a pandemic threat affecting over 2 million people. The infectious process initiates via binding of SARS-CoV-2 Spike (S) glycoprotein to host angiotensin-converting enzyme 2 (ACE2). The interaction is mediated by the receptor-binding domain (RBD) of S glycoprotein, promoting host receptor recognition and binding to ACE2 peptidase domain (PD), thus representing a promising target for therapeutic intervention. Herein, we present a computational study aimed at identifying small molecules potentially able to target RBD. Although targeting PPI remains a challenge in drug discovery, our investigation highlights that interaction between SARS-CoV…
Bioassays to monitor taspase1 function for the identification of pharmacogenetic inhibitors
2011
Background Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is limited, since neither small molecule inhibitors nor cell based functional assays for Taspase1 are currently available. Methodology/Findings Efficient cell-based assays to probe Taspase1 function in vivo are presented here. These are composed of glutathione S-transferase, autofluorescent protein variants, Taspase1 cleavage sites and rational combinations of nuclear import and export signals. The biosensors localize predominantly to the cytoplasm…
Comunicación científica o cualificación para una carrera académica: ¿Qué uso tienen los artículos en las revistas de psicología?
2019
Este trabajo analiza todas las revistas de psicología que se ha- llan incluidas en las diversas categorías de las bases de datos JCR (SCI y SSCI) y SJR durante el periodo 2014-2016 para tratar de identificar las re- vistas que se encuentran mejor posicionadas en esta disciplina, sus especia- lidades y los países con mayor número de publicaciones indexados en di- chas bases de datos. Método: Se analizó la distribución de revistas por paí- ses, cuartil y categoría para determinar la posición de las revistas en cada país e identificar los que tuviesen mayor cantidad de revistas de excelencia en psicología en la escena internacional. Resultados: Estados Unidos y Reino Unido tienen el mayor núme…