Search results for " familial"

showing 10 items of 152 documents

Long-term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia

2023

Introduction: Lomitapide is a microsomal triglyceride transfer protein inhibitor for patients with homozygous familial hypercholesterolaemia. Due to its mechanism of action, potential hepatic effects of lomitapide are of clinical interest. This study aimed to determine the long-term hepatic safety of lomitapide. Methods: Data were aggregated from the pivotal phase 3 and extension phase clinical trial with lomitapide (median 5.1 years; serum total bilirubin, transaminases, cytokeratin-18 [CK-18] and enhanced liver fibrosis [ELF] score, fat-soluble vitamins and essential fatty acids), 8-year data from the Lomitapide Observational Worldwide Evaluation Registry (LOWER) and real-world evidence f…

Settore MED/09 - Medicina Internahepatic steatosisliverLomitapidehepatic biomarkershepatic steatosiSettore BIO/18 - Geneticahepatic biomarkerSettore BIO/14 - Farmacologialiver fibrosis.hepatichepatic; hepatic biomarkers; hepatic steatosis; homozygous familial hypercholesterolaemia; liver; liver fibrosis; lomitapidehomozygous familial hypercholesterolaemialiver fibrosis
researchProduct

Melanoma nei BRCA mutation carriers

2016

Settore MED/19 - Chirurgia PlasticaMELANOMA FAMILIAL MELANOMA brca MUTATION
researchProduct

Du certificat médical exigé pour le versement des prestations familiales au titre d'un enfant étranger résidant en France

2012

International audience; Cour de cassation (2e Ch. civ.). - 16 décembre 2011

Sécurité socialeEnfant[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/LawEntrée et séjour en FranceEnfant mineurDROIT ET LIBERTE FONDAMENTAUXEnfant étrangerETRANGERPrestations familialesVie privée et familiale
researchProduct

Non-discrimination fondée sur la nationalité pour l'octroi des prestations familiales

2014

International audience; Cass., ass. plén., 5 avr. 2013, n° 11-18.947 et n° 11-17.520, D. 2013. 1009, et les obs. ; ibid. 1298, chron. O.-L. Bouvier ; ibid. 2014. 445, obs. O. Boskovic, S. Corneloup, F. Jault-Seseke, N. Joubert et K. Parrot ; AJ fam. 2013. 305, obs. I. Gallmeister, obs. S. Slama ; RDSS 2013. 527, note F. Monéger ; RTD eur. 2014. 472, obs. Ève Matringe et Mariana Lunca-Muller

Sécurité sociale[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/LawEntrée et séjour en FranceEnfant mineurETRANGERPrestations familiales
researchProduct

Familial amyloidosis: great progress for an orphan disease.

2015

Familial amyloidosis: Great progress for an orphan disease Ana Paula Barreiros1,2,*, Gerd Otto3, Bita Kahlen1, Andreas Teufel1,2, Peter R. Galle1 1Department of Internal Medicine I, Universitatsmedizin of the Johannes Gutenberg-University Mainz, Germany; 2Department of Internal Medicine I, Universitatsklinikum of the University Regensburg, Germany; 3Department of Hepatobiliary and Transplantation Surgery, Universitatmedizin of the Johannes Gutenberg-University Mainz, Germany. *Corresponding author. Address: Universitatsklinikum Regensburg, Department of Internal Medicine I, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany. Tel.: +49 941-944-7021. E-mail address: Ana.Barreiros@ukr.de …

TafamidisFamilial amyloidosismedicine.medical_specialtyPathologyPharmacological therapymedicine.medical_treatmentDiseaseLiver transplantationGlobal Healthchemistry.chemical_compoundRare DiseasesMedicineHumansTransplantation surgeryLiver transplantationHepatologybusiness.industryGeneral surgerymusculoskeletal neural and ocular physiologyDisease ManagementPharmacological therapymedicine.diseaseTafamidissurgical procedures operativechemistryGERDMorbiditybusinessFamilial amyloidosisAmyloidosis FamilialJournal of hepatology
researchProduct

Les suites de l'arrêt Mazurek dans le droit interne français

2001

International audience

Vocation successorale réduite[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/LawSUCCESSIONFiliation naturelleEnfant adultérinDROIT ET LIBERTE FONDAMENTAUXVie familialeDroits successorauxComputingMilieux_MISCELLANEOUS
researchProduct

Evaluation agroécologique de systèmes de culture en zone tropicale humide : Cas de la mise en valeur agricole d'une savane herbacée acide (Plaine des…

2013

Dans les régions tropicales humides, concilier intensification agricole et protection des ressources naturelles est un défi majeur et difficile à relever. Dans les savanes acides du nord-est laotien, des systèmes de culture de semis direct sur couverture végétale (SCV), basés sur les trois principes du non-labour, d’une couverture permanente du sol, et sur la pratique de rotations culturales diversifiées, sont proposés comme alternative technique à l’intensification agricole conventionnelle basée sur le labour. Si ces systèmes ont connu une diffusion importante et rapide dans les grandes agricultures mécanisées, leur diffusion reste néanmoins à ce jour limitée en contexte de petite agricult…

[SDE] Environmental SciencesH01 - Protection des végétaux - Considérations généralesSemis directhttp://aims.fao.org/aos/agrovoc/c_28568http://aims.fao.org/aos/agrovoc/c_28766solF08 - Systèmes et modes de culturesavane tropicale acideagroécologieBiologie du solhttp://aims.fao.org/aos/agrovoc/c_7193Performance de cultureNon-travail du sol[SDV.BV] Life Sciences [q-bio]/Vegetal Biologyhttp://aims.fao.org/aos/agrovoc/c_2018Savanehttp://aims.fao.org/aos/agrovoc/c_8511http://aims.fao.org/aos/agrovoc/c_3145http://aims.fao.org/aos/agrovoc/c_35657Petite agricultureévaluation agroécologiquehttp://aims.fao.org/aos/agrovoc/c_7182Sol acidehttp://aims.fao.org/aos/agrovoc/c_25803http://aims.fao.org/aos/agrovoc/c_1919http://aims.fao.org/aos/agrovoc/c_765http://aims.fao.org/aos/agrovoc/c_92381[SDV] Life Sciences [q-bio]Pratique culturaleLaosagriculture de conservationhttp://aims.fao.org/aos/agrovoc/c_7979Micro-organisme du solhttp://aims.fao.org/aos/agrovoc/c_89Zone tropicaleP33 - Chimie et physique du solÉcologieExploitation agricole familialehttp://aims.fao.org/aos/agrovoc/c_37938Spectroscopie infrarougeChampignonAnalyse coût avantageCulture sous couvert végétalMatière organique du solhttp://aims.fao.org/aos/agrovoc/c_36167http://aims.fao.org/aos/agrovoc/c_4176http://aims.fao.org/aos/agrovoc/c_12076http://aims.fao.org/aos/agrovoc/c_35199Propriété physicochimique du solécologie microbienneBacteriaProductivité des terressemis direct sur couverture végétaleP35 - Fertilité du solÉvaluation de l'impacthttp://aims.fao.org/aos/agrovoc/c_7160P34 - Biologie du solE80 - Économie familiale et artisanaleAnalyse économiqueTaxonomiehttp://aims.fao.org/aos/agrovoc/c_25706structure agrairehttp://aims.fao.org/aos/agrovoc/c_6825http://aims.fao.org/aos/agrovoc/c_2787Système de culturehttp://aims.fao.org/aos/agrovoc/c_2469http://aims.fao.org/aos/agrovoc/c_1971http://aims.fao.org/aos/agrovoc/c_17299U30 - Méthodes de recherchePlante de culturehttp://aims.fao.org/aos/agrovoc/c_2467http://aims.fao.org/aos/agrovoc/c_1972Cycle du carbonehttp://aims.fao.org/aos/agrovoc/c_7631
researchProduct

Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): Expert panel recommendations and proposal of an "FCS score".

2018

Familial chylomicronaemia syndrome (FCS) is a rare, inherited disorder characterised by impaired clearance of triglyceride (TG)-rich lipoproteins from plasma, leading to severe hypertriglyceridaemia (HTG) and a markedly increased risk of acute pancreatitis. It is due to the lack of lipoprotein lipase (LPL) function, resulting from recessive loss of function mutations in the genes coding LPL or its modulators. A large overlap in the phenotype between FCS and multifactorial chylomicronaemia syndrome (MCS) contributes to the inconsistency in how patients are diagnosed and managed worldwide, whereas the incidence of acute hypertriglyceridaemic pancreatitis is more frequent in FCS. A panel of Eu…

[SDV]Life Sciences [q-bio]Diagnosis toolpopulation030204 cardiovascular system & hematologyburdenapoa50302 clinical medicineLoss of Function MutationRisk FactorsChylomicrons030212 general & internal medicineAge of OnsetHypolipidemic AgentsBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina.Lipoprotein lipaseplasma triglycerideshyperlipoproteinemiaPrognosis3. Good healthUp-RegulationPhenotypeAcute pancreatitislipids (amino acids peptides and proteins)Hyperlipoproteinemia Type IAcute pancreatitis ; Familial chylomicronaemia syndrome ; Major hypertriglyceridaemia ; Multifactorial chylomicronaemiaCardiology and Cardiovascular MedicineFamilial chylomicronaemia syndromeAlgorithmsacute-pancreatitismedicine.medical_specialtyConsensushypertriglyceridemiaetiologyAcute pancreatitis; Familial chylomicronaemia syndrome; Major hypertriglyceridaemia; Multifactorial chylomicronaemia/Decision Support TechniquesDiagnosis Differential03 medical and health sciencesAcute pancreatitis; Familial chylomicronaemia syndrome; Major hypertriglyceridaemia; Multifactorial chylomicronaemia; Cardiology and Cardiovascular MedicinePredictive Value of TestsInternal medicinemedicineHumansGenetic Predisposition to DiseaseAcute pancreatitiBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine.GenotypingTriglyceridesPregnancyReceiver operating characteristicbusiness.industrysevereMultifactorial chylomicronaemiaReproducibility of Resultsmutationslipoprotein-lipase genemedicine.diseaseConfidence intervalAcute pancreatitisLipoprotein LipasePancreatitisCardiovascular System & CardiologyPancreatitisMajor hypertriglyceridaemiabusinessBiomarkersAtherosclerosis
researchProduct

Des relations familiales modifiées : de conjointe ou fille à aidante

2018

International audience

[SHS.DEMO] Humanities and Social Sciences/Demographyfille[SHS] Humanities and Social Sciences[SHS.DEMO]Humanities and Social Sciences/DemographyaidanteconjointeComputingMilieux_MISCELLANEOUS[SHS]Humanities and Social Sciencesrelations familiales
researchProduct

Coup d'arrêt aux violences conjugales ou coup d'épée dans l'eau ?

2019

International audience

[SHS.DROIT]Humanities and Social Sciences/LawCoup et Blessure[SHS.DROIT] Humanities and Social Sciences/LawJuge aux affaires familialesCoup et blessure volontairesBracelet anti-rapprochementComputingMilieux_MISCELLANEOUSViolence conjugale
researchProduct