Search results for " features"
showing 10 items of 238 documents
MetProc: Separating Measurement Artifacts from True Metabolites in an Untargeted Metabolomics Experiment
2019
High-throughput metabolomics using liquid chromatography and mass spectrometry (LC/MS) provides a useful method to identify biomarkers of disease and explore biological systems. However, the majority of metabolic features detected from untargeted metabolomics experiments have unknown ion signatures, making it critical that data should be thoroughly quality controlled to avoid analyzing false signals. Here, we present a postalignment method relying on intermittent pooled study samples to separate genuine metabolic features from potential measurement artifacts. We apply the method to lipid metabolite data from the PREDIMED (PREvención con DIeta MEDi-terránea) study to demonstrate clear remova…
genuMet: distinguish genuine untargeted metabolic features without quality control samples
2019
AbstractMotivationLarge-scale untargeted metabolomics experiments lead to detection of thousands of novel metabolic features as well as false positive artifacts. With the incorporation of pooled QC samples and corresponding bioinformatics algorithms, those measurement artifacts can be well quality controlled. However, it is impracticable for all the studies to apply such experimental design.ResultsWe introduce a post-alignment quality control method called genuMet, which is solely based on injection order of biological samples to identify potential false metabolic features. In terms of the missing pattern of metabolic signals, genuMet can reach over 95% true negative rate and 85% true posit…
Sense Equivalence in plWordNet to Princeton WordNet Mapping
2019
Abstract Though the interest in use of wordnets for lexicography is (gradually) growing, no research has been conducted so far on equivalence between lexical units (or senses) in inter-linked wordnets. In this paper, we present and validate a procedure of sense-linking between plWordNet and Princeton WordNet. The proposed procedure employs a continuum of three equivalence types: strong, regular and weak, distinguished by a custom-designed set of formal, semantic and translational features. To validate the procedure, three independent samples of 120 sense pairs were manually analysed with respect to the features. The results show that synsets from the two wordnets linked by interlingual syno…
The Semiotics of Test Design: Conceptual Framework on Optimal Item Features in Educational Assessment Across Cultural Groups, Countries, and Languages
2021
This paper offers a conceptual framework on test design from the perspective of social semiotics. Items are defined as arrangements of features intended to represent information, convey meaning, and capture information on the examinees’ knowledge or skills on a given content. The conceptual framework offers a typology of semiotic resources used to create items and discusses item representational complexity—the multiple ways in which the semiotic resources of an item are related to each other—and item semiotic alignment—the extent to which examinees share cultural experience encoded by items. Since the ability to make sense of items is shaped by the examinees’ level of familiarity with the s…
The Translation of Nursery Rhymes into Spanish: A Methodological Framework
2018
El objetivo de esta tesis es el estudio de nursery rhymes (rimas infantiles) desde una perspectiva traductológica. La traducción de estas rimas anglosajonas se encuentra de una forma cada vez más extendida en español, en ejemplos escritos y audiovisuales, donde en ocasiones aparecen de forma intertextual y fragmentada. Para proponer una discusión teórica y un marco formal en este ámbito específico de investigación, se inicia la tesis con una contextualización de términos, con la intención de establecer la posición de las nursery rhymes en relación con la infancia, la literatura infantil y su traducción. Las características orales de las nursery rhymes (su origen, patrón rítmico común, music…
El futur de la psicologia
2008
Ni que siga per consolidar i excel·lir els avanços aconseguits 'també en l'àmbit de la nostra ciència, la Psicologia', convé mirar al futur, tal com l'autor de la present col·laboració postula. I això amb perspectiva integradora i comunitària, recuperant l'harmonització de les ciències i de la vida mateixa, en forma de trilogia dels factors 'investigació, mediació computacional i tribut a la societat'. Afegeix l'autor l'exigència de gradients o nivells operatius d'intervenció i la contextualització europea i planetària en un món globalitzat que no té marxa enrere. S'aposta pel «capital humà» per assolir l'autèntic progrés i es defi neixen els trets bàsics del professional de la Psicologia, …
Grip Strength, Neurocognition, and Social Functioning in People WithType-2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizo…
2020
[Background] Frailty is a common syndrome among older adults and patients with several comorbidities. Grip strength (GS) is a representative parameter of frailty because it is a valid indicator of current and long-term physical conditions in the general population and patients with severe mental illnesses (SMIs). Physical and cognitive capacities of people with SMIs are usually impaired; however, their relationship with frailty or social functioning have not been studied to date. The current study aimed to determine if GS is a valid predictor of changes in cognitive performance and social functioning in patients with type-2 diabetes mellitus and SMIs.
Sicilian Populations of Capparis spinosa L. and Capparis orientalis Duhamel as Source of the Bioactive Flavonol Quercetin
2023
The genus Capparis is a taxon of difficult delimitation that has several species and ecotypes due to its wide heterogeneity, its extreme phenotypic diversity, and the presence of intermediate forms linked to hybridization phenomena. The Sicilian territory hosts numerous wild and cultivated populations of two spp. Capparis spinosa L. and Capparis orientalis Duhamel, which are ecologically and morphologically distinct. The caper has considerable interest and economic value for its medicinal properties, culinary uses, and cultivation characteristics. It is one of the foods with the highest quercetin content. Quercetin is a flavonol with antioxidant, anti-inflammatory, and immunostimulant prope…
Accretion in strong field gravity with eXTP
2019
In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced 'spectral-timing-polarimetry' techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.
Ag11(SG)7 : A New Cluster Identified by Mass Spectrometry and Optical Spectroscopy
2014
We report a one-step and high yield synthesis of a red-luminescent silver cluster with the molecular formula, Ag11(SG)7 (SG: glutathionate) via reduction of silver ions by sodium borohydride in the presence of the tripeptide, glutathione (GSH). The as-prepared cluster shows prominent absorption features at 485 and 625 nm in its UV-vis absorption spectrum. Aging of the as-prepared cluster solution led to the disappearance of the 625 nm peak, followed by broadening of the 485 nm peak to give three maxima at ?487, 437, and 393 nm in its absorption spectrum. These peaks remain unchanged even after polyacrylamide gel electrophoresis (PAGE), where a single band was observed confirming high purity…