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showing 10 items of 2156 documents
The role of N-methyl-D-asparate receptors in neurogenesis.
2006
The dentate gyrus continues to incorporate granule neurons during adulthood. Among the factors that we know modulate adult neurogenesis in the dentate gyrus, one of the first studied was the influence of excitatory amino-acids. These neurotransmitters, acting through NMDA receptors, are able to modulate both the proliferation of progenitor cells as well as the rate of neurogenesis in the adult dentate gyrus. However, the mechanisms by which these processes are influenced are not clearly known. Although there is no anatomical evidence of NMDA receptor expression in adult hippocampal progenitor cells or differentiating granule neurons, electrophysiological data and in vitro studies suggest th…
Hippocampal evoked potentials to pitch deviances in an auditory oddball situation in the rabbit: no human mismatch-like dependence on standard stimul…
1995
Hippocampal auditory evoked potentials (AEP) were recorded in 10 rabbits when pitch deviant tones occurred in a series of standard tones (oddball situation). In control recordings, deviant tones were presented without intervening standard tones (deviant-alone situation). All AEP deflections observed in the oddball situation were found also in the deviant-alone situation. Thus, it appeared that none of the AEP deflections to deviant tones in the oddball situation was specific to a memory trace of preceding standard tones. This observation was in contradiction to such a specificity of the mismatch negativity (MMN) found in humans. Instead, a connection to a neuronal orienting reaction interpr…
The effect of rewarding hypothalamic stimulation on behavioral and neural hippocampal responses during trace eyeblink conditioning in rabbit (Oryctol…
2005
Rabbits were trace-conditioned with a tone as a conditioned stimulus and an airpuff as an unconditioned stimulus. Electrical stimulation to the medial forebrain bundle in the lateral hypothalamus was delivered either before or after the tone-airpuff pair. The purpose of the present study was to test whether the effect of post-trial hypothalamic stimulation differed from the effect of pre-trial hypothalamic stimulation on trace conditioning in the same subjects. Additionally, hippocampal responses were measured during sessions to see if hypothalamic stimulation activated dopaminergic fibres and affected hippocampal cell functioning and thus learning. The results showed that behavioral nictit…
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties
2021
The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We furth…
Hippocampal responses to pitch deviant tones in rabbits
1997
Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane
2018
Summary Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation
2003
In HEK293 cells stably expressing alpha4beta2 nAChRs, naltrexone, but not naloxone, blocked alpha4beta2 nAChRs via an open-channel blocking mechanism. In primary hippocampal cultures, naltrexone inhibited alpha7 nAChRs up-regulated by nicotine, and in organotypic hippocampal cultures naltrexone caused a time-dependent up-regulation of functional alpha7 nAChRs that was detected after removal of the drug. These results indicate that naltrexone could be used as a smoking cessation aid.
Three dimensional reductions of four-dimensional quasilinear systems
2017
In this paper we show that integrable four dimensional linearly degenerate equations of second order possess infinitely many three dimensional hydrodynamic reductions. Furthermore, they are equipped infinitely many conservation laws and higher commuting flows. We show that the dispersionless limits of nonlocal KdV and nonlocal NLS equations (the so-called Breaking Soliton equations introduced by O.I. Bogoyavlenski) are one and two component reductions (respectively) of one of these four dimensional linearly degenerate equations.
A numerical study of the small dispersion limit of the Korteweg-de Vries equation and asymptotic solutions
2012
Abstract We study numerically the small dispersion limit for the Korteweg–de Vries (KdV) equation u t + 6 u u x + ϵ 2 u x x x = 0 for ϵ ≪ 1 and give a quantitative comparison of the numerical solution with various asymptotic formulae for small ϵ in the whole ( x , t ) -plane. The matching of the asymptotic solutions is studied numerically.
Spiking patterns emerging from wave instabilities in a one-dimensional neural lattice.
2003
The dynamics of a one-dimensional lattice (chain) of electrically coupled neurons modeled by the FitzHugh-Nagumo excitable system with modified nonlinearity is investigated. We have found that for certain conditions the lattice exhibits a countable set of pulselike wave solutions. The analysis of homoclinic and heteroclinic bifurcations is given. Corresponding bifurcation sets have the shapes of spirals twisting to the same center. The appearance of chaotic spiking patterns emerging from wave instabilities is discussed.