Search results for " forming"

Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction

2016

Abstract The development of growth factors is very promising in the field of tissue regeneration but specifically designed formulations have to be developed in order to enable such new biological entities (NBEs). In particular, the range of therapeutic concentrations is usually very low compared to other active proteins and the confinement in the target site can be of crucial importance. In-situ forming scaffolds are very promising solutions for minimally invasive intervention in cartilage reconstruction and targeting of NBEs. In this work injectable, in-situ forming gels of a temperature responsive partially degalactosylated xyloglucan (Deg-XG) incorporating the growth factor FGF-18 are fo…

In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

Energy efficiency analysis in Incremental Sheet Forming operations

2012

In literature, manufacturing processes have been studied with different approaches, but a lack in terms of their environmental impact and energy required is still present. The aim of this paper is to compute some energy efficiency analysis on a specific manufacturing process. More in detail, the attention will be focused on the Incremental Sheet Forming process in order to evaluate the required energy and how it changes for changing process conditions. Accordingly, a wide experimental investigation has been executed taking into account different process parameters (i.e. tool depth step, punch diameter, wall inclination angle and sheet thickness). The total energy consumption has been monito…

Improving formability in SPIF processes through high speed rotating tool: experimental and numerical analysis

2013

Single-point incremental forming (SPIF) is a quite new sheet-forming process which offers the possibility to deform complex parts without dedicated dies using a single-point tool and a standard three-axis CNC machine. Although the process mechanics enables higher strains with respect to traditional sheet-forming processes, research has been focused on further increasing the maximum forming angle. In the paper, a new approach is used to enhance the material formability through a localized sheet heating as a consequence of the friction work caused by high speed rotating tool. Numerical simulation was utilized to relate the effect of temperature with the main field variables distribution in th…

NEW PERSPECTIVES ON LIGHTWEIGHT SHEET METAL ALLOYS MANUFACTURING BY SINGLE POINT INCREMENTAL FORMING

2022

An economical model for investment decisions in flexible manufacturing processes: An application to sheet metal forming operations

2004

Cigarette smoke promotes inflammasome‐independent activation of caspase‐1 and ‐4 leading to gasdermin D cleavage in human macrophages

2022

Mechanisms and consequences of gasdermin D (GSDMD) activation in cigarette smoke (CS)-associated inflammation and lung disease are unknown. GSDMD is a downstream effector of caspase-1, -8, and -4. Upon cleavage, GSDMD generates pores into cell membranes. Different degrees of GSDMD activation are associated with a range of physiological outputs ranging from cell hyperactivation to pyroptosis. We have previously reported that in human monocyte-derived macrophages CS extract (CSE) inhibits the NLRP3 inflammasome and shifts the response to lipopolysaccharide (LPS) towards the TLR4-TRIF axis leading to activation of caspase-8, which, in turn, activates caspase-1. In the present work, we investig…

Nanoscale heterogeneity if glass-forming liquids: experimental advances

1998

Abstract Recent evidence indicates that in supercooled liquids the cooperativity of molecular motion extends over certain temporal and spatial ranges. A key advance is the experimental and theoretical exploration of higher-order correlation functions that can track the molecular coordinates for more than just two points in time or space. Uncontested experimental determinations of the heterogeneity length scale at the glass transition remain a major goal.

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins

2011

Here we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein toxins and being important for the pathogenesis in humans of many Gram positive and Gram negative bacteria. Their mode of action is deceptively simple, poking holes in the plasma membrane of cells. The scattered studies to date of PFT-host cell interactions indicate a handful of genes are involved in cellular defenses to PFTs. How many genes are involved in cellular defenses against PFTs and how cellular defenses are coordinated are unknown. To address these questions, we pe…

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

2011

T lymphocytes are increasingly recognized as key modulators of detrimental inflammatory cascades in acute ischaemic stroke, but the potential of T cell-targeted therapy in brain ischaemia is largely unexplored. Here, we characterize the effect of inhibiting leukocyte very late antigen-4 and endothelial vascular cell adhesion molecule-1-mediated brain invasion-currently the most effective strategy in primary neuroinflammatory brain disease in murine ischaemic stroke models. Very late antigen-4 blockade by monoclonal antibodies improved outcome in models of moderate stroke lesions by inhibiting cerebral leukocyte invasion and neurotoxic cytokine production without increasing the susceptibilit…