Search results for " formulation"

Electromechanical Numerical Analysis of an Air-Core Pulsed Alternator via Equivalent Network Formulation

2017

In this paper, the numerical analysis on an air-core pulsed alternator is presented. Since compulsators are characterized by very fast electromechanical transients, their accurate analysis requires strong coupling between the equations governing the electrical and the mechanical behaviors. The device is investigated by using a dedicated numerical code capable to take into account eddy currents, compensating windings, as well as the excitation/control circuits. Furthermore, the code is capable of modeling centrifugal forces and vibrations acting on the shaft due to electric and mechanical unbalances or to misalignments of the shaft from its centered position. This makes the code a very power…

Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites

2022

AbstractAmyloid protein aggregates are not only associated with neurodegenerative diseases and may also occur as unwanted by-products in protein-based therapeutics. Surfactants are often employed to stabilize protein formulations and reduce the risk of aggregation. However, surfactants alter protein-protein interactions and may thus modulate the physicochemical characteristics of any aggregates formed. Human insulin aggregation was induced at low pH in the presence of varying concentrations of the surfactant polysorbate 80. Various spectroscopic and imaging methods were used to study the aggregation kinetics, as well as structure and morphology of the formed aggregates. Molecular dynamics s…

Corrigendum to “Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites” [J. Colloid Interface Sci. 606…

2023

Spectrophotometric determination of promazine with an oxidative column in FIA manifolds

1992

Abstract A simple flow-injection spectrophotometric method for the determination of promazine is described. The two proposed procedures are based on the oxidation of analyte with a manganese dioxide column. Concentrations of promazine in the ranges 2–20 and 1–6 are determined with a relative standard deviation of 1.0%. The injection rates are 62 and 80 samples h −1 , respectively. The influence of foreign species and the determination of promazine in a pharmaceutical formulation are also reported.

Analysis of basic drugs by liquid chromatography with environmentally friendly mobile phases in pharmaceutical formulations

2017

Abstract Basic drugs are positively charged in the usual working pH (2–8) in reversed-phase liquid chromatography. This gives rise to a strong association with the residual ionized silanols in conventional silica-based stationary phases, which is translated in poor peak shape and high consumption of organic solvent to get appropriate retention times. Micellar mobile phases containing surfactants give rise to modified stationary phases, where silanols are masked, improving the peak shape. However, mobile phases containing the anionic surfactant sodium dodecyl sulfate (SDS) require a small amount of organic solvent to conveniently decrease the retention of cationic analytes. An alternative is…

Selective Antimicrobial Effects of Curcumin@Halloysite Nanoformulation: A Caenorhabditis elegans Study

2019

Alterations in the normal gastrointestinal microbial community caused by unhealthy diet, environmental factors, and antibiotic overuse may severely affect human health and well-being. Novel antimicrobial drug formulations targeting pathogenic microflora while not affecting or even supporting symbiotic microflora are urgently needed. Here we report fabrication of a novel antimicrobial nanocontainer based on halloysite nanotubes loaded with curcumin and protected with a dextrin outer layer (HNTs+Curc/DX) and its effective use to suppress the overgrowth of pathogenic bacteria in Caenorhabditis elegans nematodes. Nanocontainers have been obtained using vacuum-facilitated loading of hydrophobic …

Sustainability of Pension Systems in the Baltic States

2016

Objective: The objective of the paper is to identify how the concept of sustainability is understood and ensured in the pension systems of Estonia, Latvia and Lithuania; and what implications it brings to the performance of pension schemes. Research Design & Methods: Analysis of various conceptual and methodological approaches to the notion of sustainability of pension systems. Comparative analysis of present pension legislation, as well as preceding stage of pension reforms,   accompanied by a number of numerical models. Findings: The understanding of sustainability is limited by narrow ‘fiscal’ meaning in Latvia, compared to more a multifaceted concept that includes the principle of socia…

"Pour moi, le goût du soja n'est pas une barrière à la consommation. Et pour vous ?" : Effet de la culture sur les croyances, attitudes et préférence…

2010

Understanding consumers' beliefs, attitudes and sensory preference is the key to a successful development and introduction of a new food. This thesis carried out a series of cross-cultural studies, France vs. Vietnam, on consumers' representation of soy foods and on sensory perception and preference of soy yogurts, a soy derived product recently developed for French market which does not exist on the Vietnamese market. Despite a favourable image of soy in terms of nutrition and health benefices, French participants reported that the barrier to its consumption was the taste of soy. This finding was confirmed by a consumer test in which French participants gave very low hedonic evaluations to…

Wave propagation in 1D elastic solids in presence of long-range central interactions

2011

Abstract In this paper wave propagation in non-local elastic solids is examined in the framework of the mechanically based non-local elasticity theory established by the author in previous papers. It is shown that such a model coincides with the well-known Kroner–Eringen integral model of non-local elasticity in unbounded domains. The appeal of the proposed model is that the mechanical boundary conditions may easily be imposed because the applied pressure at the boundaries of the solid must be equilibrated by the Cauchy stress. In fact, the long-range forces between different volume elements are modelled, in the body domain, as central body forces applied to the interacting elements. It is …

The mechanically-based approach to 3D non-local linear elasticity theory: Long-range central interactions

2010

Abstract This paper presents the generalization to a three-dimensional (3D) case of a mechanically-based approach to non-local elasticity theory, recently proposed by the authors in a one-dimensional (1D) case. The proposed model assumes that the equilibrium of a volume element is attained by contact forces between adjacent elements and by long-range forces exerted by non-adjacent elements. Specifically, the long-range forces are modelled as central body forces depending on the relative displacement between the centroids of the volume elements, measured along the line connecting the centroids. Further, the long-range forces are assumed to be proportional to a proper, material-dependent, dis…