Search results for " frame"
showing 10 items of 1365 documents
Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: A European consensus position paper
2015
While they account for one-fifth of new cancer cases, rare cancers are difficult to study. A higher than average degree of uncertainty should be accommodated for clinical as well as for population-based decision making. Rules of rational decision making in conditions of uncertainty should be rigorously followed and would need widely informative clinical trials. In principle, any piece of new evidence would need to be exploited in rare cancers. Methodologies to explicitly weigh and combine all the available evidence should be refined, and the Bayesian logic can be instrumental to this end. Likewise, Bayesian-design trials may help optimize the low number of patients liable to be enrolled in …
Diagnoses as Selection Criteria in Drug Trials
1990
Drug trials are needed to establish the efficacy and safety of psychopharmacological agents in clearly defined indications. When the goal of treatment is more complex than removal of an isolated symptom (“difficulty in falling asleep” or “pain”) the syndrome or clinical entity to be treated is most easily classified by way of a diagnostic label (like “depression,” “schizophrenia,” or “panic disorder”). Dimensional models have many advantages: they often fit the data better and provide a conceptual framework for a continuum in the behavior from normal to abnormal. However, they have never reached the popularity of typological models (Strauss 1973, 1975, 1986) which reflect more the medical t…
Changes in group size during resource shifts reveal drivers of sociality across the tree of life
2020
ABSTRACTFrom biofilms to whale pods, organisms have repeatedly converged on sociality as a strategy to improve individual fitness. Yet, it remains challenging to identify the most important drivers—and by extension, the evolutionary mechanisms—of sociality for particular species. Here, we present a conceptual framework, literature review, and model demonstrating that the direction and magnitude of the response of group size to sudden resource shifts provides a strong indication of the underlying drivers of sociality. We catalog six functionally distinct mechanisms related to the acquisition of resources, and we model these mechanisms’ effects on the survival of individuals foraging in group…
Use and Identification of Components in Component-Based Software Development Methods
2000
New software systems are needed ever more but to keep up with this trend software developers must learn to create quality software more efficiently. One approach is to (re-)use components as building blocks of the new software. Recently there has been more interest to create component-based software development methods to support this. In this article we first set out requirements for reuse-based software development and then evaluate three component-based methods, namely Catalysis, OMT++, and Unified Process. As a conclusion we argue that evaluated methods produce prefabricated components and that component-based means that software developers can change better components to existing syste…
The Many Faces of Special Education Within RTI Frameworks in the United States and Finland
2015
Response to intervention (RTI) can be considered an everyday practice in many parts of the United States, whereas, in Finland, only recently has a new framework for support in learning taken shape. Choosing Finland as the comparative partner for this policy paper is justified as its educational system has been widely referenced on the basis of good Programme for International Student Assessment (PISA) results. The results of the present comparative article showed first, that the U.S. RTI was primarily intended for diagnosing and preventing learning disabilities whereas the Finnish RTI is mainly an administrative structure for support. Second, the U.S. RTI includes clear definitions regardin…
Gypsy endogenous retrovirus maintains potential infectivity in several species of Drosophilids.
2008
Abstract Background Sequences homologous to the gypsy retroelement from Drosophila melanogaster are widely distributed among drosophilids. The structure of gypsy includes an open reading frame resembling the retroviral gene env, which is responsible for the infectious properties of retroviruses. Results In this study we report molecular and phylogeny analysis of the complete env gene from ten species of the obscura group of the genus Drosophila and one species from the genus Scaptomyza. Conclusion The results indicate that in most cases env sequences could produce a functional Env protein and therefore maintain the infectious capability of gypsy in these species.
Propuestas teóricas en la investigación sobre acoso escolar: una revisión
2013
Four decades of research into peer bullying have produced an extensive body of knowledge. This work attempts to provide an integrative theoretical framework, which includes the specific theories and observations. The main aim is to organize the available knowledge in order to guide the development of effective interventions. To that end, several psychological theories are described that have been used and/or adapted with the aim of understanding peer bullying. All of them, at different ecological levels and different stages of the process, may describe it in terms of the relational dynamics of power. It is concluded that research needs to take this integrative framework into account, that i…
A macro-modelling approach for the analysis of infilled frame structures considering the effects of openings and vertical loads
2015
During the last decades, several macro-models have been proposed for the modelling of the infill panels' contribution to the lateral strength of frames. Despite all this effort, a robust model, which takes into account the influence of the vertical load, is not yet available. Furthermore, the influence of the very common case of infill walls with openings, such as windows and doors, has been neglected in all the code provisions that have been published so far. In this paper, an updated macro-model, based on the equivalent pin-jointed diagonal compressive strut, is presented. The proposed macro-model is able to represent the stiffening effect of the infill panel with openings by taking into …
Non-response bias as a likely cause of the association between young maternal age at the time of delivery and the risk of cancer in the offspring.
2003
Some epidemiological studies have shown an association between young maternal age at the time of delivery and risk of cancer in the offspring. In a recent German case-control study, there was a twofold increase in the leukaemia risk for children whose mothers were aged < 20 years at the time of delivery. As the prevalence of younger mothers among control families was particularly low, data on maternal age distributions for the general population of Germany were obtained in order to examine the representativeness of the control sample. Despite the excellent sampling frame based on data from complete and up-to-date population registries and a satisfactory response rate among controls ( approx…
Balance with logic-measuring the performance and sustainable development efforts of an NPO in rural Ethiopia.
2021
The analysis of performance of Not-for-profit organisations (NPOs) is difficult because there are several objectives and perspectives to NPO performance and accountability, especially if considered sustainably and in long term. This suggests that performance analysis and measurement of NPOs might also involve multiple perspectives, such as in Balanced Scorecard (BSC) or in the Logical Framework (LF) models. This article is a case study of analysing the sustainable development and performance of an NPO in rural Ethiopia. We propose the Logic Balanced Scorecard (LBSC) model that combines elements of BSC and LF. This proposal was preliminarily used and tested in a five-year interventionist acc…