Search results for " function"
showing 10 items of 9395 documents
C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-R…
2019
Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C-X-C motif chemokine ligand 12 (CXCL12) and its receptor, C-X-C motif chemokine receptor 4 (CXCR4). CXCR4 antagonists mobilize inflammatory cells and promote infarct repair, but the cellular mechanisms are unclear. Methods: We investigated the therapeutic potential and mode of action of the peptidic macrocycle CXCR4 antagonist POL5551 in mice with reperfused MI. We applied cell depletion and adoptive transfer strategies using lymphocyte-deficient Rag1 knockout mice; DEREG mice, which express a diphth…
Chest fistula repair
2020
Chest wall plays a fundamental role in the human body, as it represents a protective cage around vital organs such as heart and lungs. Chest wall fistula is a rare and insidious condition that could lead to severe functional and aesthetical consequences, and thus represents a serious surgical challenge. Goals of reconstructive surgery are to preserve the respiratory function, to provide visceral protection, and to assure the best possible cosmetic outcome. In this chapter, we present an overview of all key principles in chest wall fistula management and repair.
A Self-Contained Cylinder Drive with Indirectly Controlled Hydraulic Lock
2020
This paper presents a self-contained pump-controlled hydraulic linear drive including an innovative load holding sub-circuit. For safety critical applications such as crane manipulators, locking valves or load holding valves are enforced by legislation, but the load holding functionality may also be used actively to decrease the energy consumption for applications where the load is kept stationary for longer periods of time. The system proposed in this paper is based on a simple hydraulic architecture using two variablespeed electric motors each connected to a fixed-displacement pump. This architecture is well-known inacademic literature, but in this paper a novel load holding sub-circuit h…
Approximation of Baskakov type Pólya–Durrmeyer operators
2017
In the present paper we propose the Durrmeyer type modification of Baskakov operators based on inverse Polya-Eggenberger distribution. First we estimate a recurrence relation by using hypergeometric series. We give a global approximation theorem in terms of second order modulus of continuity, a direct approximation theorem by means of the Ditzian-Totik modulus of smoothness and a Voronovskaja type theorem. Some approximation results in weighted space are obtained. Also, we show the rate of convergence of these operators to certain functions by illustrative graphics using the Maple algorithms.
Co-learning of recursive languages from positive data
1996
The present paper deals with the co-learnability of enumerable families L of uniformly recursive languages from positive data. This refers to the following scenario. A family L of target languages as well as hypothesis space for it are specified. The co-learner is fed eventually all positive examples of an unknown target language L chosen from L. The target language L is successfully co-learned iff the co-learner can definitely delete all but one possible hypotheses, and the remaining one has to correctly describe L.
Reducing CAS-SDCI space. Using selected spaces in configuration interaction calculations in an efficient way
2002
A new method is presented, which allows an important reduction of the size of some Configuration Interaction (CI) matrices. Starting from a Complete Active Space (CAS), the numerous configurations that have a small weight in the CAS wave function are eliminated. When excited configurations (e.g., singly and doubly excited) are added to the reference space, the resulting MR-SDCI space is reduced in the same proportion as compared with the full CAS–SDCI. A set of active orbitals is chosen, but some selection of the most relevant excitations is performed because not all the possible excitations act as SDCI generators. Thanks to a new addressing technique, the computational time is drastically …
On the intrinsic complexity of learning
1995
A new view of learning is presented. The basis of this view is a natural notion of reduction. We prove completeness and relative difficulty results. An infinite hierarchy of intrinsically more and more difficult to learn concepts is presented. Our results indicate that the complexity notion captured by our new notion of reduction differs dramatically from the traditional studies of the complexity of the algorithms performing learning tasks.
Energy-weighted M1 sum rule with explicit δ degrees of freedom
1985
Abstract The influence of Δ degrees of freedom on the energy-weighted M1 sum rule is investigated and applied to 2 H and 4 He. Using π- and ρ-exchange potentials a reduction of the potential contribution of the order of 50% is obtained. The absolute value of the sum rule is strongly dependent on the short-range behaviour of the nuclear wave function. Furthermore, the contribution of c.m. effects is evaluated and found to be of the order of 5–10%.
Tetrolet-based reduced reference image quality assessment approach
2014
In this paper, we propose a new reduced reference image quality assessment (RRIQA) scheme. For this purpose, we use a statistical-based method in a new adaptive Haar wavelet transform domain, called Tetrolet. Firstly, we decompose the reference and distorted images and we obtain the Tetrolet coefficients for each image. Secondly, we use a marginal Generalized Gaussian Density (GGD) to model each subband coefficients. Finally, the distortion measure is computed using the Kullback Leibler Divergence (KLD) between GGD Probability density function (PDFs). Experimental results show the efficiency of the proposed method when comparing to those reported in the literature.
Modelling the regenerative niche: a major challenge in biomaterials research
2015
By definition, biomaterials are developed for clinical application. In the field of regenerative medicine their principal function is to play a significant, and, if possible, an instructive role in tissue healing. In the last analysis the latter involves targeting the 'regenerative niche'. The present paper will address the problem of simulating this niche in the laboratory and adopts a life science approach involving the harnessing of heterotypic cellular communication to achieve this, that is, the ability of cells of different types to mutually influence cellular functions. Thus, co-culture systems using human cells are the methodological focus and will concern four exemplary fields of re…