Search results for " function"
showing 10 items of 9395 documents
The Large Hadron–Electron Collider at the HL-LHC
2021
The Large Hadron-Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operations. This report represents an update to the LHeC's conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LH…
Deliberate Play and Preparation Jointly Benefit Motor and Cognitive Development: Mediated and Moderated Effects
2016
In light of the interrelation between motor and cognitive development and the predictive value of the former for the latter, the secular decline observed in motor coordination ability as early as preschool urges identification of interventions that may jointly impact motor and cognitive efficiency. The aim of this study was twofold. It (1) explored the outcomes of enriched physical education, centered on deliberate play and cognitively challenging variability of practice, on motor coordination and cognitive processing; (2) examined whether motor coordination outcomes mediate intervention effects on children’s cognition, while controlling for moderation by lifestyle factors as outdoor play h…
1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16)
2020
Protein Phosphatase 2A, PP2A, the principal Serine/threonine phosphatase, has major roles in broad range of signaling pathways that include regulation of cell cycle, cell proliferation and neuronal signaling. The loss of function of PP2A is linked with many human diseases, like cancer and neurodegenerative disorders. Protein phosphatase 2A (PP2A) functions as tumor suppressor and its tumor suppressor activity is inhibited by the overexpression of PP2A inhibitor proteins in most of the cancers. ARPP-19/ARPP-16 has been identified as one of the potential PP2A inhibitor proteins. Here, we report the resonance assignment of backbone 1H, 13C and 15N atoms of human ARPP-19 and ARPP-16 proteins. T…
High‐resolution 3D forest structure explains ecomorphological trait variation in assemblages of saproxylic beetles
2022
1. Climate, topography and the 3D structure of forests are major drivers affecting local species communities. However, little is known about how the specific functional traits of saproxylic (wood-living) beetles, involved in the recycling of wood, might be affected by those environmental characteristics. 2. Here, we combine ecological and morphological traits available for saproxylic beetles and airborne laser scanning (ALS) data in Bayesian trait-based joint species distribution models to study how traits drive the distributions of more than 230 species in temperate forests of Europe. 3. We found that elevation (as a proxy for temperature and precipitation) and the proportion of conifers p…
Asymptotic Hölder regularity for the ellipsoid process
2020
We obtain an asymptotic Hölder estimate for functions satisfying a dynamic programming principle arising from a so-called ellipsoid process. By the ellipsoid process we mean a generalization of the random walk where the next step in the process is taken inside a given space dependent ellipsoid. This stochastic process is related to elliptic equations in non-divergence form with bounded and measurable coefficients, and the regularity estimate is stable as the step size of the process converges to zero. The proof, which requires certain control on the distortion and the measure of the ellipsoids but not continuity assumption, is based on the coupling method.
What Contributes to the Measured Chiral Optical Response of the Glutathione-Protected Au25 Nanocluster?
2023
The water-soluble glutathione-protected [Au25(GSH)18]−1 nanocluster was investigated by integrating several methodologies such as molecular dynamics simulations, essential dynamics analysis, and state-of-the-art time-dependent density functional theory calculations. Fundamental aspects such as conformational, weak interactions and solvent effects, especially hydrogen-bonds, were included and found to play a fundamental role in assessing the optical response of this system. Our analysis demonstrated not only that the electronic circular dichroism is extremely sensitive to the solvent presence but also that the solvent itself plays an active role in the optical activity of such system, formin…
Dire estetica, fare estetica con l'architettura
2013
Il saggio affronta il tema del'"estetica realizzata" focalizzandosi sulla maniera peculiare del "fare estetica" nel caso specifico dell'architettura. "Frammenti" della disciplina dell'estetica ricorrono randomicamente nel "discorso" sull'architettura: sia che si tratti di una organica trattazione teorica, sia che si tratti della didattica della progettazione architettonica sia che si tratti dell'interlocuzione tra architetto e cliente. Il progetto infatti si costruisce spesso attraverso un dialogo tra architetto "madre" e cliente "padre" (Filarete, Wright). A tal riguardo l'autore propone originalmente la definizione di progetto di architettura come "atto estetologico diffuso". Successivame…
Form follows Function? Misunderstanding and Value of a Sullivan’s Concept
2012
L’attuale dibattito nel campo dell’architettura e del design ha riportato in auge la relazione tra forma e funzione. Per comprendere il significato di questi concetti può essere utile una rilettura storica dei grandi Maestri del Movimento moderno, a partire da Louis H. Sullivan, considerato “il padre” del funzionalismo. Ma al contempo emerge la necessità di interpretare i concetti di “forma” e “funzione” secondo la prospettiva della storia delle idee. Questa chiave di lettura, rivelando la stratificazione semantica che ha determinato nei secoli la complessità delle nozioni di “forma” e “funzione”, dimostra l’erroneità di certe interpretazioni “razionalistiche” e mette in luce la stretta rel…
Poincaré Type Inequalities for Vector Functions with Zero Mean Normal Traces on the Boundary and Applications to Interpolation Methods
2019
We consider inequalities of the Poincaré–Steklov type for subspaces of H1 -functions defined in a bounded domain Ω∈Rd with Lipschitz boundary ∂Ω . For scalar valued functions, the subspaces are defined by zero mean condition on ∂Ω or on a part of ∂Ω having positive d−1 measure. For vector valued functions, zero mean conditions are applied to normal components on plane faces of ∂Ω (or to averaged normal components on curvilinear faces). We find explicit and simply computable bounds of constants in the respective Poincaré type inequalities for domains typically used in finite element methods (triangles, quadrilaterals, tetrahedrons, prisms, pyramids, and domains composed of them). The second …
Estimates for the Differences of Certain Positive Linear Operators
2020
The present paper deals with estimates for differences of certain positive linear operators defined on bounded or unbounded intervals. Our approach involves Baskakov type operators, the kth order Kantorovich modification of the Baskakov operators, the discrete operators associated with Baskakov operators, Meyer&ndash