Search results for " function"
showing 10 items of 9395 documents
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
2019
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman primates (NHP) are a fast-acting T-cell subset, with capacities to rapidly expand and produce Th1 and cytotoxic cytokines in response to phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by Mycobacterium tuberculosis (Mtb) or others. However, whether IL-12 signaling pathway mediates fast-acting and Th1 or anti-microbial features of Vγ2Vδ2 T cells remains poorly defined. Here, we show that IL-12, but not other IL-12 fami…
The effect of residential urban greenness on allergic respiratory diseases in youth: A narrative review
2020
Abstract Background Environmental exposures across the life course may be a contributor to the increased worldwide prevalence of respiratory and allergic diseases occurring in the last decades. Asthma and rhinoconjunctivitis especially contribute to the global burden of disease. Greenness has been suggested to have beneficial effects in terms of reduction of occurrence of allergic respiratory diseases. However, the available evidence of a relationship between urban greenness and childhood health outcomes is not yet conclusive. The current review aimed at investigating the current state of evidence, exploring the relationship between children's exposure to residential urban greenness and dev…
«Axí com...» Le comparazioni nella lirica di Jordi de Sant Jordi
2005
Jordi de Sant Jordi uses more than thirty comparisons in his lyric poetry. These may be classified on the basis of their typology and semantic functions: true comparisons (where two elements are compared by means of a connector, the first being defined as ‘real’ and corresponding to the situation of the lyric persona, the second, figurative, presenting in metaphorical terms the same characteristics as the first element); comparisons between the ‘real’ situation and that of an unspecified human being, to which reference is made by means of the demonstrative ‘the one’ («axí com cell...»); hyperbolic comparisons, where the ‘real’ element is given hyperbolically as having to the same or to a gr…
High Performance 3D PET Reconstruction Using Spherical Basis Functions on a Polar Grid
2011
Statistical iterative methods are a widely used method of image reconstruction in emission tomography. Traditionally, the image space is modelled as a combination of cubic voxels as a matter of simplicity. After reconstruction, images are routinely filtered to reduce statistical noise at the cost of spatial resolution degradation. An alternative to produce lower noise during reconstruction is to model the image space with spherical basis functions. These basis functions overlap in space producing a significantly large number of non-zero elements in the system response matrix (SRM) to store, which additionally leads to long reconstruction times. These two problems are partly overcome by expl…
Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human.
2013
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognit…
La percepción de la funcionalidad familiar. Confirmación de su estructura bifactorial (The perception of the family functionality. Confirmation of it…
2012
Valid, reliable and easy-to-use instruments are required for the assessment of family functionality. The present study confirms the two-factor structure of a 23-item family Functionality Scale, providing indices of reliability and external validity in a sample of 185 families with teenage children. Parent discrepancy is analyzed, and the statistical descriptors of this variable are presented in the two dimensions that constitute the scale: Facilitator and Disturber. The instrument is useful for assessing functionality and for calculating parental discrepancy in the perception of family life, which is also an indicator of functionality.
The difference of free light chains as a predictor of kidney damage in patients with Multiple Myeloma
2022

 Background: Multiple myeloma (MM) is a malignant neoplasm characterized by the clonal expansion of plasma cells that can release monoclonal immunoglobulins (monoclonal component) or part of theme. Since 2001, the k and λ serum free light chains (sFLC) evaluation and their ratio (rFLC) have made up the laboratory analysis more sensitive and precise in MM patients. The role of rFLC has been widely studied and discussed and now it is validated in the literature. Instead, the value of free light chains difference (dFLC), especially in MM is less known yet. The aim of this study is to evaluate the relationship between the dFLC and the kidney damage parameters in patients with MM, in compa…
Towards a sustainable leader-follower relationship: constructive dissensus, organizational virtuousness and happiness at work (haw)
2020
This paper examines how leaders and followers can interact positively under complex and bounded conditions. For this purpose, this paper conceptualizes and measures the concept of constructive dissensus. Constructive dissensus relates to a mutual understanding leading to a situation of coregulation. In addition, the relationship between constructive dissensus and happiness at work is examined on the basis of affective events theory. Furthermore, the mediating role of organizational virtuousness is assessed. Through structural equation modeling, a multilevel analysis was performed. Data from 130 bank branches and 606 employees were gathered. The results reveal a direct effect of constructive…
System identification via optimised wavelet-based neural networks
2003
Nonlinear system identification by means of wavelet-based neural networks (WBNNs) is presented. An iterative method is proposed, based on a way of combining genetic algorithms (GAs) and least-square techniques with the aim of avoiding redundancy in the representation of the function. GAs are used for optimal selection of the structure of the WBNN and the parameters of the transfer function of its neurones. Least-square techniques are used to update the weights of the net. The basic criterion of the method is the addition of a new neurone, at a generic step, to the already constructed WBNN so that no modification to the parameters of its neurones is required. Simulation experiments and compa…
Jurisdiction in cases of divorce, legal separation or marriage annulment
2021
The subject of coordination is fundamental for the functioning of jurisdictional rules of the Regulation n.2016/1103 on matrimonial property regimes and Regulation n.2016/1104 on the property consequences of registered partnerships. Both Property Regimes Regulations have the purpose of gathering litigation before the courts of one Member State and have the related procedures managed by the courts of the same Member State. Recital 34 of Regulation No. 2016/1103 specifies that matters of matrimonial property regime related to proceedings pending before the court of a member state hearing an application for divorce, legal separation or marriage annulment should be dealt with by the courts of t…