Search results for " functioning"
showing 10 items of 285 documents
Frontiers of metal-coordinating drug design
2020
INTRODUCTION: The occurrence of metal ions in biomolecules is required to exert vital cellular functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors targeting their metal-moiety. As well, the discovery of cisplatin ushered the rational discovery of metal-containing-drugs. The use of both drug types exploiting metal–ligand interactions is well established to treat distinct pathologies. Therefore, characterizing and leveraging metal-coordinating drugs is a pivotal, yet challenging, part of medicinal chemistry. AREA COVERED: Atomic-level simulations are increasingly employed to overcome the challenges met by traditional drug-discovery approaches and to compleme…
Parental Psychological Control, Quality of Family Context and Life Satisfaction Among Italian Adolescents
2012
The aim of the study was to explore the unique and common contributions of parental psychological control and family functioning to global life satisfaction among Italian adolescents while considering the type of parental psychological control: dependencyoriented and achievement-oriented. Two hundred fifty-five adolescents (104 boys and 151 girls) from 15 to 17 years of age (mean age = 15.98, SD = .76) completed self-report measures on perceived parental psychological control, dependency- and achievement-oriented, family functioning and global life satisfaction. Correlation analyses indicated that parental psychological control oriented to both dependency and achievement was negatively rela…
The Role of Individual and Relational Characteristics on Alcohol Consumption among Italian Adolescents: A Discriminant Function Analysis
2013
The aim of the present study was to explore the association between family functioning, coping strategies, peer influences and alcohol use among Italian adolescents. Nine hundred and sixty-three Italian adolescents, aged from 14 to 17 years, completed self-report measures assessing alcohol use, family functioning, and coping strategies. According to previous research, adolescents were categorized into non-drinkers, social, binge and heavy drinkers. Results showed that adolescents belonging to groups characterized by alcohol misuse differ in terms of coping strategies, family functioning dimensions, and typology of friends. In particular, heavy drinkers appeared to have more friends who drin…
Rasch Analysis of Authentic Evaluation of Young Children's Functioning in Classroom Routines.
2021
This study evaluated the functioning of children in early childhood education classroom routines, using the 3M Functioning in Preschool Routines Scale. A total of 366 children aged 36 to 70 months and 22 teachers from six early childhood education centers in Spain participated in the study. The authors used the Rasch model to determine the item fit and the difficulty of the items in relation to children's ability levels in this age range. The Rasch Differential Item Functioning (DIF) analysis by child age groups showed that the item difficulty differed according to the children's age and according to their levels of competence. The results of this study supported the reliability and validit…
Liberal and Conservative Differential Item Functioning Detection Using Mantel-Haenszel and SIBTEST: Implications for Type I and Type II Error Rates
2004
The aim of this work was to determine, in terms of Type I and Type II error rates, the risks of applying various statistical procedures for evaluating differential item functioning. To this end, the authors carried out a simulation study in which the Mantel-Haenszel and SIBTEST procedures were applied in conjunction. The variables manipulated were sample size and distribution of ability between groups. Results indicated that, although there was a high rate of agreement between the procedures, the joint Type I and Type II error rate may vary substantially from that obtained when each of the procedures was applied separately. Furthermore, the authors analyzed empirical data to obtain informat…
Perceived family continuity: Implications for family identification and psychological well-being
2011
AbstractResearch has shown that people tend to perceive the national and regional groups to which they belong as temporally persistent. In this paper we conducted two studies to investigate that the family may also be perceived as having different degrees of continuity through time, and that those perceptions have implications on family identity and psychological well-being. In the first study (N = 149; with a mean age of 23, SD = 5.7), we found that perceived family continuity was positively correlated with several family related variables (e.g., family functioning, perceived family entitativity) and with psychological well-being. Our second study (N = 152; with a mean age of 40.80, SD = 1…
Axons take a dive
2014
In the walls of the lateral ventricles of the adult mammalian brain, neural stem cells (NSCs) and ependymal (E1) cells share the apical surface of the ventricular-subventricular zone (V-SVZ). In a recent article, we show that supraependymal serotonergic (5HT) axons originating from the raphe nuclei in mice form an extensive plexus on the walls of the lateral ventricles where they contact E1 cells and NSCs. Here we further characterize the contacts between 5HT supraependymal axons and E1 cells in mice, and show that suprependymal axons tightly associated to E1 cells are also present in the walls of the human lateral ventricles. These observations raise interesting questions about the functio…
Biciliated ependymal cell proliferation contributes to spinal cord growth
2012
Two neurogenic regions have been described in the adult brain, the lateral ventricle subventricular zone and the dentate gyrus subgranular zone. It has been suggested that neural stem cells also line the central canal of the adult spinal cord. Using transmission and scanning electron microscopy and immunostaining, we describe here the organization and cell types of the central canal epithelium in adult mice. The identity of dividing cells was determined by 3D ultrastructural reconstructions of [3H]thymidine-labeled cells and confocal analysis of bromodeoxyuridine labeling. The most common cell type lining the central canal had two long motile (9+2) cilia and was vimentin+, CD24+, FoxJ1+, So…
The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up
2021
Abstract Background Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between 4 epigenetic clocks (Horvath’s and Hannum’s DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a 3-year follow-up. Method We studied 63- to 76-year-old women (N = 413) from the Finnish Twin Study on Aging. DNAm was measured from blood samples at baseline. Age acceleration (AgeAccel), that is, discrepancy between chronological age and DNAm age, was determined as residuals from linear model. Physical functioning was assessed under standardized laboratory conditions at b…
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.
2021
We would like to thank all the families that participated in these studies for their generous contribution. Detailed acknowledgements and funding can be found in Sup plementary Material.