Search results for " generation."
showing 10 items of 1108 documents
Second Harmonic Emission From Dielectric Nanoresonators in the Absorption Regime
2023
We study second harmonic generation in dielectric nanocylinders as a function of the wavelength of the incident field and geometrical dimensions. Uncommonly, we consider a spectral range in which the emitted nonlinear signal is partially absorbed by the dielectric. Surprisingly, we reveal that the second harmonic efficiency does not decrease as the imaginary part of the complex dielectric refractive index increases. Indeed, the presence of higher order multipoles supported by the resonators at the fundamental wavelength can significantly boost the generated second harmonic signal even in the dielectric absorption spectral region achieving nonlinear efficiency of the same order of magnitude …
Nuevas ecologías del aprendizaje en el currículo: la era digital en la escuela The new learning ecology in the curriculum: the digital age at school
2020
espanolLa expansion y crecimiento de los ambientes de aprendizaje como resultado de la integracion de las TIC han facilitado el surgimiento de distintas formas de interrelacion educativa, provocando un interes en el estudio de las ecologias del aprendizaje y de los ecosistemas educativos digitales. Cada vez es mas necesario un cambio profundo en el proceso ensenanza-aprendizaje ya que el alumnado actualmente dentro del aula demanda un tipo de aprendizaje activo, vivencial y digital. El objetivo de este trabajo es analizar los nuevos modelos o paradigmas del aprendizaje basados en los intereses de las nuevas generaciones que aprenden en un contexto rodeado de las TIC. La metodologia empleada…
Systemic circulating microRNA landscape in Lynch syndrome
2022
AbstractMicroRNAs (miRs) are non-coding RNA-molecules that regulate gene expression. Global circulating miR (c-miR) expression patterns (c-miRnome) change with carcinogenesis in various sporadic cancers. Therefore, aberrantly expressed c-miRs could have diagnostic, predictive and prognostic potential in molecular profiling of cancers. c-miR functions in carriers of inherited pathogenic mismatch-repair gene variants (path_MMR), also known as Lynch syndrome (LS), have remained understudied. LS cohort provides an ideal population for biomarker mining due to increased lifelong cancer risk and excessive cancer occurrence. Using high-throughput sequencing and bioinformatic approaches, we conducte…
Aplicacions de Next Generation Sequencing en organismes no model: caracterització dels transcriptomes de verins de serps
2015
Tesis doctoral. 213 páginas. Figuras, bibliografía y anexos.
Targeting the tumor mutanome for personalized vaccination therapy
2012
Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.
Usher syndrome : molecular analysis of USH2 genes and development of a next-generation sequencing platform
2013
El síndrome de Usher (USH) es una enfermedad hereditaria autosómica recesiva, caracterizada por la asociación de hipoacusia neurosensorial, retinosis pigmentaria y, en ocasiones, alteración de la función vestibular. Clínicamente, el USH se puede clasificar en tres tipos (USH1, USH2 y USH3), principalmente en base a la gravedad y progresión de la hipoacusia y presencia o no de disfunción vestibular. El USH es heterogéneo tanto a nivel clínico como genético y, hasta la fecha, se han descrito 11 genes implicados en la enfermedad. El USH2 es la forma más común y tres son los genes responsables conocidos: USH2A (72 exones), GPR98 (90 exones) y DFNB31 (12 exones). USH2A es responsable de más del …
Microbial controls of greenhouse gas emissions from boreal lakes
2015
Critical issues and future prospects of the secondary substation in smart grid context
2014
This paper is focused on the new role of the secondary substation in the smart grids context. This innovative view has been proposed and developed in the framework of two Research Projects: NewCabELARC Project and Reipersei Project. The latter provides a concrete and comprehensive low cost solutions for the smart grid monitoring and control, allowing the real diffusion and integration of Distributed Generation and the full exploitation of Renewable Energy Sources. In this field, this paper shows how the secondary substation (SS) takes the role of smart transducer node where innovative devices can be located, collecting the measurement data coming from the field devices (power and energy met…
A universal optical all-fiber omnipolarizer
2012
International audience; Wherever the polarization properties of a light beam are of concern, polarizers and polarizing beamsplitters (PBS) are indispensable devices in linear-, nonlinear- and quantum-optical schemes. By the very nature of their operation principle, transformation of incoming unpolarized or partially polarized beams through these devices introduces large intensity variations in the fully polarized outcoming beam(s). Such intensity fluctuations are often detrimental, particularly when light is post-processed by nonlinear crystals or other polarization-sensitive optic elements. Here we demonstrate the unexpected capability of light to self-organize its own state-of-polarizatio…
Measurement of the soliton number in guiding media through continuum generation.
2020
No general approach is available yet to measure directly the ratio between chromatic dispersion and the nonlinear coefficient, and hence the soliton number for a given optical pulse, in an arbitrary guiding medium. Here we solve this problem using continuum generation. We experimentally demonstrate our method in polarization-maintaining and single-mode fibers with positive and negative chromatic dispersion. Our technique also offers new opportunities to determine the chromatic dispersion of guiding media over a broad spectral range while pumping at a fixed wavelength. (C) 2020 Optical Society of America